卒中后失语非损伤侧脑电功率谱网络特征研究

doi:10.3969/j.issn.1006-9771.2020.06.013

《中国康复理论与实践》 ›› 2020, Vol. 26 ›› Issue (6): 692-696.doi: 10.3969/j.issn.1006-9771.2020.06.013

卒中后失语非损伤侧脑电功率谱网络特征研究

樊瑞文,黄幸,李晓琳,鄢鹤铭,舒鑫,孔乔,李昌明,常静玲()

北京中医药大学东直门医院神经内科,北京市 100700

收稿日期:2019-12-18 修回日期:2020-02-02 出版日期:2020-06-25 发布日期:2020-06-29
通讯作者: 常静玲 E-mail:ear6979@163.com
作者简介:樊瑞文(1991-),女,汉族,江苏镇江市人,博士研究生,主要研究方向：中医药防治脑病的临床与神经影像学实验研究。
基金资助:
1.北京自然科学基金重点项目(7181005);2.国家自然科学基金项目(81973790);3.北京中医药大学科研创新团队项目(2019-JYB-TD003)

Characteristics of Electroencephalogram Power Spectrum Network on Uninjured Side of Post-stroke Aphasia

FAN Rui-wen,HUANG Xing,LI Xiao-lin,YAN He-ming,SHU Xin,KONG Qiao,LI Chang-ming,CHANG Jing-ling()

Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

Received:2019-12-18 Revised:2020-02-02 Published:2020-06-25 Online:2020-06-29
Contact: CHANG Jing-ling E-mail:ear6979@163.com
Supported by:
Beijing Natural Science Foundation(7181005);National Natural Science Foundation of China(81973790);Research and Innovation Team of Beijing University of Chinese Medicine(2019-JYB-TD003)

摘要/Abstract

摘要：

目的探索左侧损伤卒中后失语(PSA)患者右脑脑电(EEG)功率谱网络效应特点。方法 2018年12月至2019年6月,招募12例仅左脑半球损伤的PSA患者(PSA组)以及相匹配的健康成年人12例(健康对照组)。采用中国康复研究中心失语症检查(CRRCAE)评价语言功能,并采集脑电数据。对比Alpha和Theta功率谱功能连接特点,与语言亚项进行相关分析。结果 PSA患者右侧脑功能网络在中央区与额、顶及额顶联合区的Alpha与Theta频段功能连接增强,在颞顶、顶枕区与额、额顶、额中央区的Theta频段功能连接减弱。右侧顶枕区至中央区Alpha频段功能连接增强与患者语言表达能力降低相关(P < 0.05),而顶、顶枕与前额、额中央的Theta频段功能连接减弱与患者语言的说、读、抄写、听写和计算等能力相关( r= -0.676~-0.717, P < 0.05)。结论 EEG功率谱网络可反映右脑功能网络重组情况,右脑额-顶-中央网络功能连接变化可能与PSA语言功能损伤密切相关,可作为PSA疗效评价客观指征。

关键词: 脑卒中, 失语, 脑电, 功率谱网络, 大脑

Abstract:

Objective To clarify the characteristics of electroencephalogram (EEG) power spectrum network of right hemisphere in patients with post-stroke aphasia (PSA) after left brain damaged.Methods From December, 2018 to June, 2019, twelve PSA patients with left hemisphere injury were recruited and twelve healthy adults were matched as control group. China Rehabilitation Research Center aphasia examination (CRRCAE) was used to evaluated the linguistic function, and the EEG was collected. The functional connection characteristics of Alpha and Theta power spectrum were compared, and the correlation with language items was analyzed.Results In PSA patients, the functional connection enhanced in Alpha and Theta frequency bands of central area, frontal, parietal and frontal-parietal joint areas, and decreased in Theta frequency bands of temporoparietal, parietal-occipital area, frontal, fronta-parietal and frontal central areas. The enhancement of alpha frequency functional connection from the right parietal occipital region to the central region was significantly correlated to the reduction of the expression ability (P < 0.05), while the weakening of theta frequency functional connection between the right parietal occipital region and the forehead and the center of the forehead was significantly correlated to the ability of speaking, reading, copying, dictation and calculation ( r= -0.676~-0.717, P < 0.05). Conclusion EEG power spectrum network can reflect the reorganization of right brain function network, and the change of right frontal parietal central network function connection may be closely related to PSA language injury and recovery.

Key words: stroke, aphasia, electroencephalogram, power spectrum network, brain

中图分类号:

R743.3

樊瑞文,黄幸,李晓琳,鄢鹤铭,舒鑫,孔乔,李昌明,常静玲. 卒中后失语非损伤侧脑电功率谱网络特征研究[J]. 《中国康复理论与实践》, 2020, 26(6): 692-696.

FAN Rui-wen,HUANG Xing,LI Xiao-lin,YAN He-ming,SHU Xin,KONG Qiao,LI Chang-ming,CHANG Jing-ling. Characteristics of Electroencephalogram Power Spectrum Network on Uninjured Side of Post-stroke Aphasia[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(6): 692-696.

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组别	n	性别(男/女,n)	年龄(岁)	教育程度(年)
健康对照组	12	10/2	57±9	13±3
PSA组	12	8/4	51±12	12±3
t/χ²值		0.552	-1.307	-0.801
P值		0.458	0.206	0.434

语言亚项	频段	电极	r	P值
大声读	Alpha	PO4-C6	-0.676	0.032
复述	Alpha	PO4-C6	-0.717	0.013

语言亚项	频段	电极	r	P值
说	Theta	P8-FCZ	0.657	0.028
说	Theta	PO4-F2	0.683	0.021
读	Theta	P2-FP2	0.686	0.020
		PO4-AF4	0.657	0.028
		PO4-F2	0.718	0.013
		PO4-F4	0.661	0.027
抄写	Theta	P8-FZ	0.613	0.045
		P8-F2	0.677	0.022
		PO6-F2	0.696	0.017
		PO6-F4	0.633	0.037
		PO8-F2	0.661	0.027
听写	Theta	PO8-C2	0.673	0.023
计算	Theta	PO4-F4	0.794	0.011
		PO4-FC2	0.733	0.025
		PO6-FC2	0.680	0.044
		PO8-FC2	0.688	0.04

卒中后失语非损伤侧脑电功率谱网络特征研究

Characteristics of Electroencephalogram Power Spectrum Network on Uninjured Side of Post-stroke Aphasia

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