骶神经根磁刺激联合索利那新治疗女性难治性膀胱过度活动症的效果

doi:10.3969/j.issn.1006-9771.2020.06.019

《中国康复理论与实践》 ›› 2020, Vol. 26 ›› Issue (6): 725-729.doi: 10.3969/j.issn.1006-9771.2020.06.019

骶神经根磁刺激联合索利那新治疗女性难治性膀胱过度活动症的效果

朱文静¹,吕坚伟²(),吕婷婷²,宋旭³

1.上海中医药大学附属岳阳中西医结合医院泌尿科,上海市 200437
2.上海交通大学医学院附属仁济医院南院泌尿科,上海市 201112
3.上海中医药大学附属第七人民医院泌尿科,上海市 200137

收稿日期:2019-12-24 修回日期:2020-01-26 出版日期:2020-06-25 发布日期:2020-06-29
通讯作者: 吕坚伟 E-mail:ljwass@126.com
作者简介:朱文静(1981-),女,汉族,天津市人,硕士,副主任医师,主要研究方向：尿控和前列腺疾病。
基金资助:
1.上海市中医重点专科培育项目(泌尿专科)(Urology);2.浦东新区卫生系统重点学科建设基金项目(PWZxk2017-16)

Effects of Sacral Nerve Root Magnetic Stimulation Combined with Solifenacin on Refractory Overactive Bladder in Women

ZHU Wen-jing¹,LÜ Jian-wei²(),LÜ Ting-ting²,SONG Xu³

1. Department of Urology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
2. Department of Urology, South Campus of Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201112, China
3. Department of Urology, the Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China

Received:2019-12-24 Revised:2020-01-26 Published:2020-06-25 Online:2020-06-29
Contact: LÜ Jian-wei E-mail:ljwass@126.com
Supported by:
Shanghai Key Specialty Cultivation Project of Traditional Chinese Medicine(Urology);Key Discipline Construction Project of Pudong Health and Family Planning Commision of Shanghai(PWZxk2017-16)

摘要/Abstract

摘要：

目的探讨骶神经根磁刺激联合索利那新治疗女性难治性膀胱过度活动症(OAB)的临床效果。方法 2017年1月至12月,120例难治性OAB患者随机分为骶神经根磁刺激组(n = 40)、索利那新组(n = 40)和联合治疗组(n = 40)。治疗前后分别评价三组排尿日记(日间排尿次数、夜间排尿次数、单次排尿量、尿急次数)、尿动力指标(初始尿意膀胱容量、最大膀胱容量)和膀胱过度活动症评分(OABSS)。结果骶神经根磁刺激组2例、索利那新组1例、联合治疗组1例脱落。联合治疗组日间排尿次数、夜间排尿次数、单次排尿量、尿急次数、初始尿意膀胱容量、最大膀胱容量和OABSS评分均优于骶神经根磁刺激组和索利那新组(P < 0.05)。结论骶神经根磁刺激联合索利那新治疗女性难治性膀胱过度活动症效果优于单一疗法。

关键词: 难治性膀胱过度活动症, 骶神经根磁刺激, 索利那新

Abstract:

Objective To investigate the clinical efficacy of sacral nerve root magnetic stimulation combined with Solifenacin in women with refractory overactive bladder (OAB).Methods From January to December, 2017, 120 women with refractory OAB were randomly divided into sacral nerve root magnetic stimulation group (group A, n = 40), Solifenacin group (group B, n = 40), and combined treatment group (group C, n = 40). Before and after treatment, they were assessed with the urine diary (number of daily urination, number of nightly urination, single urine output, number of urgent urination), urodynamic index (initial urinary bladder capacity, maximum bladder capacity) and Overactive Bladder Symptom Score (OABSS).Results Two patients from group A, one from group B and one from group C were dropped out. The number of daily urination, the number of nightly urination, the single urine output, the number of urgent urination, the initial urinary bladder capacity and maximum bladder capacity, and OABSS were better in group C than in groups A and B (P < 0.05). Conclusion Sacral nerve root magnetic stimulation combined with Solifenacin is effective and better than anyone alone on women with refractory OAB.

Key words: refractory overactive bladder, sacral nerve root magnetic stimulation, Solifenacin

中图分类号:

R454.1

朱文静,吕坚伟,吕婷婷,宋旭. 骶神经根磁刺激联合索利那新治疗女性难治性膀胱过度活动症的效果[J]. 《中国康复理论与实践》, 2020, 26(6): 725-729.

ZHU Wen-jing,LÜ Jian-wei,LÜ Ting-ting,SONG Xu. Effects of Sacral Nerve Root Magnetic Stimulation Combined with Solifenacin on Refractory Overactive Bladder in Women[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(6): 725-729.

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参考文献 21

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组别	n	年龄(岁)	病程(月)
骶神经根磁刺激组	40	48.25±19.11	36.57±13.46
索利那新组	40	47.34±18.76	37.41±14.83
联合治疗组	40	49.06±20.83	35.03±12.94
F值		0.31	0.11
P值		0.74	0.90

组别	n	日间排尿次数(n)		夜间排尿次数(n)		单次排尿量(ml)		尿急次数(n)
组别	n	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
骶神经根磁刺激组	38	17.56±5.64	8.56±1.73	8.11±2.42	4.37±1.87	73.76±27.07	93.14±33.27	8.33±2.57	5.14±1.46
索利那新组	39	17.33±5.70	8.78±2.09	7.89±2.52	4.45±1.94	74.24±27.56	91.43±32.61	8.10±2.79	5.05±1.75
联合治疗组	39	17.67±4.33	5.67±1.45^a	8.12±2.76	2.45±0.88^a	73.71±23.68	126.19±53.80^a	8.24±2.91	3.23±1.70^a
Z值		0.066	-2.630	1.272	-3.760	0.214	4.125	0.051	-3.007
P值		0.968	0.045	0.530	0.025	0.887	0.010	0.874	0.034

组别	n	初始尿意膀胱容量(ml)		最大膀胱容量(ml)
组别	n	治疗前	治疗后	治疗前	治疗后
骶神经根磁刺激组	38	64.33±22.91	88.91±21.10	160.67±39.09	196.52±41.62
索利那新组	39	63.71±29.43	89.28±21.16	161.79±39.31	197.47±40.84
联合治疗组	39	63.09±32.96	115.86±23.79^a	159.31±36.56	220.95±46.03^a
Z值		0.740	3.912	0.308	5.856
P值		0.691	0.017	0.827	0.009

组别	n	治疗前	治疗后
骶神经根磁刺激组	38	8.52±2.46	4.38±1.59
索利那新组	39	8.86±2.82	4.19±1.47
联合治疗组	39	8.95±2.89	2.71±0.90^a
Z值		0.779	-3.115
P值		0.678	0.030

骶神经根磁刺激联合索利那新治疗女性难治性膀胱过度活动症的效果

Effects of Sacral Nerve Root Magnetic Stimulation Combined with Solifenacin on Refractory Overactive Bladder in Women

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