疏通矫正手法对cblC型甲基丙二酸尿症患儿功能的效果

doi:10.3969/j.issn.1006-9771.2020.08.017

《中国康复理论与实践》 ›› 2020, Vol. 26 ›› Issue (8): 964-968.doi: 10.3969/j.issn.1006-9771.2020.08.017

疏通矫正手法对cblC型甲基丙二酸尿症患儿功能的效果

郑宏¹,梁瑞星²,陆相朋¹,张建奎¹,王怡珍¹,谢克功¹,靳辉¹,郭素真¹,赵书营¹,张弛¹,李晓孟¹,毛馨¹,孙金龙¹,李华伟¹,冯斌¹,马丙祥¹()

1.河南中医药大学第一附属医院,河南郑州市 450000
2.濮阳市中医院,河南濮阳市 457001

收稿日期:2020-06-10 修回日期:2020-07-03 出版日期:2020-08-25 发布日期:2020-08-31
通讯作者: 马丙祥 E-mail:mbx1963@126.com
作者简介:郑宏(1972-),女,汉族,河南濮阳市人,主任医师,硕士生导师,主要研究方向：儿童神经遗传代谢病。
基金资助:
1.国家重点研发计划项目(2017YFC1001700);1.国家重点研发计划项目(2017YFC1001704);2.河南省科技厅科技攻关项目(182102310299);3.河南省特色学科中医学学科建设项目(STS-ZYX-20170147);4.河南省中医管理局国家中医临床研究基地科研专项(2018JDZX021)

Effect of Dredging Correcting Manipulation on Stunting in Children with cblC Methylmalonic Aciduria

ZHENG Hong¹,LIANG Rui-xing²,LU Xiang-peng¹,ZHANG Jian-kui¹,WANG Yi-zhen¹,XIE Ke-gong¹,JIN Hui¹,GUO Su-zhen¹,ZHAO Shu-ying¹,ZHANG Chi¹,LI Xiao-meng¹,MAO Xin¹,SUN Jin-long¹,LI Hua-wei¹,FENG Bin¹,MA Bing-xiang¹()

1. The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China
2. Puyang Hospital of Chinese Medicine, Puyang, Henan 457001, China

Received:2020-06-10 Revised:2020-07-03 Published:2020-08-25 Online:2020-08-31
Contact: MA Bing-xiang E-mail:mbx1963@126.com
Supported by:
National Key Research and Development Program of China(2017YFC1001700);National Key Research and Development Program of China(2017YFC1001704);Henan Provincial Department of Science and Technology Research Project(182102310299);Construction Project of Chinese Medicine Characteristics Discipline in Henan Province(STS-ZYX-20170147);Scientific Research Project of National Clinical Research Base of Chinese Medicine in Henan Province(2018JDZX021)

摘要/Abstract

摘要：

目的探讨疏通矫正手法对cblC型甲基丙二酸尿症(MMA)患儿功能的效果。方法 2017年10月至2018年10月,本院收治的cblC型MMA伴发育迟缓3~36月龄的患儿72例,根据家长意愿分为对照组(n = 36)和试验组(n = 36)。对照组采用常规西药治疗,试验组在此基础上加用疏通矫正手法治疗。采用中文版Griffiths发育量表(GDS-C)进行发育评估,同时测定身长、体质量和头围。结果对照组脱落6例,试验组脱落5例。治疗前,两组GDS-C各领域和总发育商均无显著性差异(P> 0.05)。治疗后,两组GDS-C各领域发育商和总发育商均显著升高(t > 6.110, P < 0.001);试验组粗大运动、个人与社会、手眼协调和总发育商均高于对照组( t > 2.154, P< 0.05);试验组身长大于对照组(t = 2.027, P < 0.05)。结论疏通矫正手法可促进cblC型MMA发育迟缓患儿神经心理发育和体格发育。

关键词: 甲基丙二酸尿症, 神经发育迟缓, 疏通矫正手法, Griffiths发育量表

Abstract:

Objective To observe the effect of Dredging Correcting Manipulation on cblC methylmalonic aciduria (MMA).Methods From October, 2017 to October, 2018, 72 children with cblC MMA combined with growth retardation were divided into control group (n = 36) and experimental group (n = 36) according to the consent of their parents. The control group accepted routine medicine, and the experimental group received Dredging Correcting Manipulation in addition. The Griffiths Development Scale-Chinese version (GDS-C) was used to evaluate the two groups before and after treatment. At the same time, body length, body mass and head circumference were measured.Results Six cases in the control group and five cases in the experimental group were dropped out. There was no significant difference in the development quotients of GDS-C in gross movement, personal and social, hearing and speech, hand-eye coordination, operation and total quotient between two groups before treatment (P> 0.05). After treatment, all the development quotients increased in both groups (t > 6.110, P < 0.001), and the development quotients of GDS-C in gross movement, personal and social, hand-eye coordination and total quotient were higher in the experimental group than in the control group ( t > 2.154, P< 0.05), as well as the body length (t = 2.027, P < 0.05). Conclusion Dredging Correcting Manipulation can promote the neuropsychological and physical development of children with cblC MMA combined with retardation.

Key words: methylmalonic aciduria, neurodevelopmental retardation, Dredging Correcting Manipulation, Griffiths Development Scale

中图分类号:

R725.8

郑宏,梁瑞星,陆相朋,张建奎,王怡珍,谢克功,靳辉,郭素真,赵书营,张弛,李晓孟,毛馨,孙金龙,李华伟,冯斌,马丙祥. 疏通矫正手法对cblC型甲基丙二酸尿症患儿功能的效果[J]. 《中国康复理论与实践》, 2020, 26(8): 964-968.

ZHENG Hong,LIANG Rui-xing,LU Xiang-peng,ZHANG Jian-kui,WANG Yi-zhen,XIE Ke-gong,JIN Hui,GUO Su-zhen,ZHAO Shu-ying,ZHANG Chi,LI Xiao-meng,MAO Xin,SUN Jin-long,LI Hua-wei,FENG Bin,MA Bing-xiang. Effect of Dredging Correcting Manipulation on Stunting in Children with cblC Methylmalonic Aciduria[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(8): 964-968.

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组别	n	治疗前	治疗后	t值	P值
对照组	30	49.90±16.01	56.90±16.00	7.727	< 0.001
试验组	31	52.26±18.62	69.11±19.30	21.393	< 0.001
t值		0.529	2.698
P值		0.599	0.009

组别	n	治疗前	治疗后	t值	P值
对照组	30	46.40±17.75	53.50±16.46	6.121	< 0.001
试验组	31	49.65±19.05	65.60±18.64	22.184	< 0.001
t值		0.688	2.688
P值		0.494	0.009

组别	n	治疗前	治疗后	t值	P值
对照组	30	42.70±15.40	50.05±15.99	7.191	< 0.001
试验组	31	43.35±15.66	53.74±15.56	11.361	< 0.001
t值		0.165	0.912
P值		0.870	0.365

组别	n	治疗前	治疗后	t值	P值
对照组	30	50.10±16.39	58.19±16.63	6.416	< 0.001
试验组	31	50.48±17.09	68.22±19.60	13.485	< 0.001
t值		0.089	2.157
P值		0.929	0.035

组别	n	治疗前	治疗后	t值	P值
对照组	30	49.80±17.09	58.97±17.76	6.110	< 0.001
试验组	31	50.26±17.39	65.32±18.78	11.486	< 0.001
t值		0.104	1.358
P值		0.918	0.180

疏通矫正手法对cblC型甲基丙二酸尿症患儿功能的效果

Effect of Dredging Correcting Manipulation on Stunting in Children with cblC Methylmalonic Aciduria

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组别	n	治疗前	治疗后	t值	P值
对照组	30	50.10±16.39	55.51±15.38	7.930	< 0.001
试验组	31	49.20±19.21	64.41±16.86	19.183	< 0.001
t值		0.563	2.154
P值		0.576	0.036

组别	n	身长(cm)	体质量(kg)	头围(cm)
对照组	30	0.65±0.26	0.28±0.20	0.29±0.19
试验组	31	0.78±0.24	0.24±0.28	0.28±0.17
t值		2.027	-0.662	0.281
P值		0.047	0.511	0.780