线粒体介导远端缺血后处理抗脑缺血再灌注损伤的机制研究进展

doi:10.3969/j.issn.1006-9771.2020.09.011

《中国康复理论与实践》 ›› 2020, Vol. 26 ›› Issue (9): 1061-1065.doi: 10.3969/j.issn.1006-9771.2020.09.011

线粒体介导远端缺血后处理抗脑缺血再灌注损伤的机制研究进展

陶苗苗¹,徐鸣曙²(),张英杰²,程爱芳¹,邓韵怡¹

1.上海中医药大学,上海市 200120
2.上海市针灸经络研究所,上海市 200030

收稿日期:2019-12-23 修回日期:2020-03-23 出版日期:2020-09-25 发布日期:2020-09-24
通讯作者: 徐鸣曙 E-mail:mingshuxu@163.com
作者简介:陶苗苗(1994-),女,汉族,安徽宣城市人,硕士研究生,主要研究方向：针灸治疗神经系统疾病。|徐鸣曙(1978-),男,汉族,上海市人,博士,副研究员,主要研究方向：针灸治疗神经系统疾病。
基金资助:
1.上海市科学技术委员会科研计划项目(17ZR1427500);2.上海市卫生和计划生育委员会科研课题(201640128);3.上海市人才发展基金项目(2017104)

Advance in Role of Mitochondria in Remote Ischemic Postconditioning for Cerebral Ischemia-reperfusion Injury (review)

TAO Miao-miao¹,XU Ming-shu²(),ZHANG Ying-jie²,CHENG Ai-fang¹,DENG Yun-yi¹

1. Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China
2. Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China

Received:2019-12-23 Revised:2020-03-23 Published:2020-09-25 Online:2020-09-24
Contact: XU Ming-shu E-mail:mingshuxu@163.com
Supported by:
Shanghai Committee of Science and Technology Research Plan(17ZR1427500);Shanghai Municipal Commission of Health and Family Planning Research Plan(201640128);Shanghai Talent Development Fund(2017104)

摘要/Abstract

摘要：

线粒体作为缺血后神经细胞凋亡的关键靶点,与脑缺血再灌注损伤关系密切。远端缺血后处理能缓解脑缺血再灌注损伤,可能与缓解线粒体损伤,改善其功能紊乱有关系,机制涉及细胞色素C/caspase、线粒体自噬、线粒体ATP敏感性钾通道和线粒体膜通透性转运孔等四个方面。

关键词: 脑缺血再灌注损伤, 远端缺血后处理, 线粒体, 综述

Abstract:

Mitochondria, as the key passway of neuronal apoptosis after ischemia, is closely related to cerebral ischemia-reperfusion injury. Remote ischemic post-conditioning can alleviate cerebral ischemia-reperfusion injury, and its mechanism is related to alleviating mitochondrial injury and improving its dysfunction. In this paper, cytochrome C/caspase, mitophagy, mitochondrial ATP-sensitive K⁺ channel and mitochondrial permeability transitionpore were reviewed.

Key words: cerebral ischemia-reperfusion injury, remote ischemic post-conditioning, mitochondria, review

陶苗苗,徐鸣曙,张英杰,程爱芳,邓韵怡. 线粒体介导远端缺血后处理抗脑缺血再灌注损伤的机制研究进展[J]. 《中国康复理论与实践》, 2020, 26(9): 1061-1065.

TAO Miao-miao,XU Ming-shu,ZHANG Ying-jie,CHENG Ai-fang,DENG Yun-yi. Advance in Role of Mitochondria in Remote Ischemic Postconditioning for Cerebral Ischemia-reperfusion Injury (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(9): 1061-1065.

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线粒体介导远端缺血后处理抗脑缺血再灌注损伤的机制研究进展

Advance in Role of Mitochondria in Remote Ischemic Postconditioning for Cerebral Ischemia-reperfusion Injury (review)

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