运动通过调控线粒体质量控制改善肌少症的研究进展

doi:10.3969/j.issn.1006-9771.2020.09.012

《中国康复理论与实践》 ›› 2020, Vol. 26 ›› Issue (9): 1066-1070.doi: 10.3969/j.issn.1006-9771.2020.09.012

运动通过调控线粒体质量控制改善肌少症的研究进展

王岑依^1,²,梁计陵³,司誉豪²,陈宁⁴()

1.苏州大学体育学院,江苏苏州市 215021
2.杜肯大学兰格斯健康科学学院,美国宾夕法尼亚州匹兹堡,PA 15282
3.武汉体育学院研究生院,湖北武汉市 430079
4.武汉体育学院健康科学学院,运动训练监控湖北省重点实验室,天久运动营养食品研发中心,湖北武汉市 430079

收稿日期:2019-09-15 修回日期:2019-12-19 出版日期:2020-09-25 发布日期:2020-09-24
通讯作者: 陈宁 E-mail:nchen510@gmail.com
作者简介:王岑依(1994-),女,汉族,湖南株洲市人,博士研究生,主要研究方向：运动与物理因子治疗对慢性疾病康复。|陈宁(1972-),男,汉族,湖北武汉市人,博士,教授,博士研究生导师,主要研究方向：运动与营养干预对慢性疾病预防与康复。
基金资助:
1.国家自然科学基金面上项目(31571228);2.湖北省体育教育与健康促进学科群项目;3.湖北省高等学校优秀中青年科技创新团队项目(T201624)

Advance in Role of Mitochondrial Quality Control in Exercise for Sarcopenia (review)

WANG Cen-yi^1,²,LIANG Ji-ling³,SI Yu-hao²,CHEN Ning⁴()

1. Soochow University School of Sport, Suzhou, Jiangsu 215021, China
2. John G. Rangos Sr. School of Health Sciences, Duquesne University, Pittsburgh, PA15282, USA
3. Graduate School, Wuhan Sports University, Wuhan, Hubei 430079, China
4. Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan, Hubei 430079, China

Received:2019-09-15 Revised:2019-12-19 Published:2020-09-25 Online:2020-09-24
Contact: CHEN Ning E-mail:nchen510@gmail.com
Supported by:
National Natural Science Foundation of China(31571228);Hubei Sports Education and Health Promotion Discipline Group Foundation;Hubei Scientific and Technological Innovation Team Program Foundation for Middle-aged and Young Scientist(T201624)

摘要/Abstract

摘要：

肌少症是骨骼肌质量和力量逐渐下降的过程,是老年人面临的主要健康挑战。线粒体可通过改善生物合成、抗氧化防御、融合/分裂动力学以及线粒体自噬等,维持骨骼肌自身结构和功能的完整性,线粒体功能障碍是导致肌少症的重要因素之一。运动疗法可通过激活与调控线粒体生物合成和线粒体自噬,调节线粒体质量控制,延缓和防治肌少症发生和进展。

关键词: 肌少症, 线粒体质量控制, 运动干预, 线粒体自噬, 综述

Abstract:

Sarcopenia is a process in which skeletal muscle mass and strength are gradually declining, resulting a main health challenge for the old adults. Mitochondria can maintain the integrity of structure and function of skeletal muscle by improving biosynthesis, antioxidant defense, fusion/fission dynamics and mitophagy. Mitochondrial dysfunction is a important factor leading to the complex etiology of sarcopenia. Exercise can regulate mitochondrial quality control pathways by activating mitochondrial biogenesis and mitophagy to maintain optimal mitochondrial function, thereby delaying and preventing the onset and progression of sarcopenia.

Key words: sarcopenia, mitochondrial quality control, exercise intervention, mitophagy, review

王岑依,梁计陵,司誉豪,陈宁. 运动通过调控线粒体质量控制改善肌少症的研究进展[J]. 《中国康复理论与实践》, 2020, 26(9): 1066-1070.

WANG Cen-yi,LIANG Ji-ling,SI Yu-hao,CHEN Ning. Advance in Role of Mitochondrial Quality Control in Exercise for Sarcopenia (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2020, 26(9): 1066-1070.

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运动通过调控线粒体质量控制改善肌少症的研究进展

Advance in Role of Mitochondrial Quality Control in Exercise for Sarcopenia (review)

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