Netrin-1对脑梗死损伤的保护和修复作用研究进展

doi:10.3969/j.issn.1006-9771.2021.03.011

《中国康复理论与实践》 ›› 2021, Vol. 27 ›› Issue (3): 316-319.doi: 10.3969/j.issn.1006-9771.2021.03.011

Netrin-1对脑梗死损伤的保护和修复作用研究进展

张馨予¹,杜小正¹(),王金海²,何文洁¹,王娜娜¹,王若州¹,井维尧¹,杨尚伟¹

^1.甘肃中医药大学，甘肃兰州市 730000
^2.兰州大学第二医院，甘肃兰州市 730030

收稿日期:2020-02-19 修回日期:2020-05-11 出版日期:2021-03-25 发布日期:2021-04-02
通讯作者: 杜小正 E-mail:lz-duxiaozheng@163.com
作者简介:张馨予(1995-)，女，汉族，辽宁沈阳市人，硕士研究生，主要研究方向：针刺治疗脑梗死的相关研究。
基金资助:
甘肃省中医药管理局科研课题(GZK-2017-10);甘肃省科技厅创新基地和人才计划项目(18JR3RA196);国家自然科学基金项目(81960896)

Advance of Netrin-1 for Protection and Repairment of Injuries after Cerebral Infarction (review)

Xin-yu ZHANG¹,Xiao-zheng DU¹(),Jin-hai WANG²,Wen-jie HE¹,Na-na WANG¹,Ruo-zhou WANG¹,Wei-yao JING¹,Shang-wei YANG¹

^1.Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, China
^2.Lanzhou University Second Hospital, Lanzhou, Gansu 730030, China

Received:2020-02-19 Revised:2020-05-11 Published:2021-03-25 Online:2021-04-02
Contact: Xiao-zheng DU E-mail:lz-duxiaozheng@163.com
Supported by:
Gansu Provincial Administration of Traditional Chinese Medicine Research Project(GZK-2017-10);Gansu Provincial Science and Technology Department Innovation Base and Talent Plan(18JR3RA196);National Natural Science Foundation of China(81960896)

摘要/Abstract

摘要：

Netrin-1已被证实对脑梗死导致的损伤有保护和修复作用，主要表现为抑制细胞凋亡、抑制炎症反应、促进血管新生和促进轴突再生等方面。Netrin-1与脑梗死的发生和预后也有一定相关性。Netrin-1临床应用仍需进一步探讨。

关键词: 脑梗死, Netrin-1, 凋亡, 炎症, 血管再生, 轴突再生, 综述

Abstract:

Netrin-1 may protect and repair the damage caused by cerebral infarction, in terms of inhibiting apoptosis and inflammatory, and promoting angiogenesis and axon regeneration, etc. Netrin-1 may associate with the pathogenesis and outcome of cerebral infarction. The application of Netrin-1 in clinic needs more researches.

Key words: cerebral infarction, Netrin-1, apoptosis, inflammatory, angiogenesis, axon regeneration, review

中图分类号:

R743.32

张馨予,杜小正,王金海,何文洁,王娜娜,王若州,井维尧,杨尚伟. Netrin-1对脑梗死损伤的保护和修复作用研究进展[J]. 《中国康复理论与实践》, 2021, 27(3): 316-319.

Xin-yu ZHANG,Xiao-zheng DU,Jin-hai WANG,Wen-jie HE,Na-na WANG,Ruo-zhou WANG,Wei-yao JING,Shang-wei YANG. Advance of Netrin-1 for Protection and Repairment of Injuries after Cerebral Infarction (review)[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(3): 316-319.

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Netrin-1对脑梗死损伤的保护和修复作用研究进展

Advance of Netrin-1 for Protection and Repairment of Injuries after Cerebral Infarction (review)

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