《中国康复理论与实践》 ›› 2021, Vol. 27 ›› Issue (5): 497-503.doi: 10.3969/j.issn.1006-9771.2021.05.001

• 专题 • 上一篇    下一篇

卒中后失语静息态脑功能成像亚频段低频振幅脑活动研究

李晓琳,徐敏杰,曹云,张丹莉,舒鑫,李昌明,周雨帆,谭逸海,谭中建,常静玲()   

  1. 北京中医药大学东直门医院神经内科,北京市 100700
  • 收稿日期:2021-01-14 修回日期:2021-03-01 出版日期:2021-05-25 发布日期:2021-05-26
  • 通讯作者: 常静玲 E-mail:ear6979@163.com
  • 作者简介:李晓琳(1991-),女,汉族,黑龙江北安市人,博士研究生,主要研究方向:中医药防治脑病的临床与神经影像学实验研究。
  • 基金资助:
    北京市自然科学基金重点项目(7181005);国家自然科学基金面上项目(81973790);北京中医药大学科研创新团队项目(2019-JYB-TD003)

Frequency-dependent Alterations in Amplitude of Low-frequency Fluctuations in Resting-state Functional Magnetic Resonance Imaging of Post Stroke Aphasia

Xiao-lin LI,Min-jie XU,Yun CAO,Dan-li ZHANG,Xin SHU,Chang-ming LI,Yu-fan ZHOU,Yi-hai TAN,Zhong-jian TAN,Jing-ling CHANG()   

  1. Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • Received:2021-01-14 Revised:2021-03-01 Published:2021-05-25 Online:2021-05-26
  • Contact: Jing-ling CHANG E-mail:ear6979@163.com
  • Supported by:
    Beijing Natural Science Foundation(7181005);National Science Foundation of China (General)(81973790);Beijing University of Chinese Medicine Research and Innovation Team(2019-JYB-TD003)

摘要: 目的

探索卒中后失语(PSA)患者局部脑神经活动在不同频段的特征及西方失语成套测试(WAB)评分与特定频段的关系。

方法

2015年3月至2018年5月,招募本院PSA患者15例(患者组)和年龄、性别、受教育程度等匹配的健康成年人15例(对照组),采用WAB测试;采集静息态功能性磁共振成像(rs-fMRI),计算低频振幅(ALFF)和比率低频振幅(fALFF)在0.01~0.08 Hz、0.027~0.073 Hz、0.01~0.027 Hz的变化;提取不同频段差异脑区ALFF和fALFF与患者组WAB评分进行相关性分析。

结果

在0.01~0.08 Hz,患者组右侧中央前回ALFF增高。在0.027~0.073 Hz,患者组右侧中央前回ALFF增高;患者组右侧小脑Crus2区fALFF减弱,右侧小脑Crus2区fALFF与WAB信息量(r = -0.576, P = 0.025)、听理解(r = -0.658, P = 0.008)、复述评分(r = -0.616, P = 0.014)和失语商(r = -0.611, P = 0.016)呈负相关;在0.01~0.027 Hz,患者组左顶下缘角回fALFF减弱,左顶下缘角回fALFF与信息量评分(r = 0.538, P = 0.039)和失语商(r = 0.526, P = 0.044)呈正相关。

结论

PSA患者的静息态fALFF异常具有频率依赖性,不同频段脑fALFF存在频段特异性神经功能改变。

关键词: 卒中后失语, 低频振幅, 比率低频振幅, 亚频段分析

Abstract: Objective

To explore the characteristics of local brain neural activity in post stroke aphasia (PSA) patients in different frequency bands and the relationship between Western Aphasia Battery (WAB) scores and specific frequency bands.

Methods

From March, 2015 to May, 2018, 15 PSA patients, and 15 healthy adults as controls matched for age, gender and education were recruited. They were assessed with WAB and scaned with resting-state functional magnetic resonance imaging. The amplitude of low-frequency fluctuation (ALFF) and fractional amplitude of low-frequency fluctuation (fALFF) on the frequency bands of 0.01-0.08 Hz, 0.027-0.073 Hz, and 0.01-0.027 Hz were calculated. The ALFF and fALFF in different frequency bands were extracted and the correlation with the WAB scores in the patients were analyzed.

Results

On 0.01-0.08 Hz, ALFF increased in the right precentral gyrus in the patients. On 0.027-0.073 Hz, ALFF increased values in the right precentral gyrus, and fALFF decreased in the right cerebellar Crus2 region; fALFF in the right cerebellar Crus2 region negatively correlated with the scores of information content (r = -0.576, P = 0.025), auditory comprehension (r = -0.658, P = 0.008), repetition (r = -0.616, P = 0.014) and aphasia quotient (r = -0.611, P = 0.016) of WAB. On 0.01-0.027 Hz, the fALFF decreased in the left inferior parietal limbic gyrus, and positively correlated with the scores of information content (r = 0.538, P = 0.039) and aphasia quotient (r = 0.526, P = 0.044).

Conclusion

Resting-state fALFF abnormalities in PSA patients are frequency-dependent, which associate with some frequency-specific neurofunctional alterations.

Key words: post stroke aphasia, amplitude of low-frequency fluctuation, fractional amplitude of low-frequency fluctuation, frequency-dependent alterations

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