《中国康复理论与实践》 ›› 2021, Vol. 27 ›› Issue (7): 765-773.doi: 10.3969/j.issn.1006-9771.2021.07.005
收稿日期:
2021-01-14
修回日期:
2021-03-31
出版日期:
2021-07-25
发布日期:
2021-07-28
通讯作者:
黄海量
E-mail:06000031@sdutcm.edu.cn
作者简介:
李玲玲(1997-),女,汉族,河北邯郸市人,硕士研究生,主要研究方向:中西医康复技术实践与循证评价研究。|黄海量(1975-),男,汉族,博士,教授,硕士研究生导师,主要研究方向:中西医康复技术循证评价研究。
基金资助:
LI Ling-ling1,YU Ying2,JIA Yu-qi1,HUANG Hai-liang1()
Received:
2021-01-14
Revised:
2021-03-31
Published:
2021-07-25
Online:
2021-07-28
Contact:
HUANG Hai-liang
E-mail:06000031@sdutcm.edu.cn
Supported by:
摘要:
目的 系统评价脑机接口(BCI)对脑卒中患者上肢运动功能的康复疗效,并比较不同BCI的疗效差异。
方法 检索PubMed、Embase、Cochrane Library、Web of Science、CNKI、Wanfang Data和CBM数据库,搜集关于BCI改善脑卒中患者上肢运动功能的随机对照试验,检索时限从建库至2020年10月。按照Cochrane系统评价手册对纳入文献进行质量评价并提取数据,采用RevMan 5.3和ADDIS 1.16.8软件进行统计分析。
结果 最终纳入14篇文献,共504例患者。Meta分析显示,BCI可提高Fugl-Meyer评定量表上肢部分(FMA-UE)评分(MD = 6.81, 95%CI 1.51~12.11,P < 0.05)、上肢动作研究量表评分(MD = 7.68, 95%CI 0.49~14.88, P < 0.05)和改良Barthel指数评分(MD = 8.91, 95%CI 5.57~12.25, P < 0.001)。亚组分析显示,BCI干预超过4周(MD = 9.44, 95%CI 1.83~17.04, P < 0.05)或不足4周(MD = 5.18, 95%CI 2.84~7.51, P < 0.001)均可提高FMA-UE评分。不同驱动设备BCI对FMA-UE评分最佳效果的网状Meta分析概率排序为电刺激仪(P = 0.53)、视觉反馈(P = 0.41)和机器辅助(P = 0.06)。
结论 BCI能改善脑卒中患者上肢运动功能和日常生活活动能力,以驱动设备为电刺激仪的BCI效果最好。
中图分类号:
李玲玲,于莹,贾雨琦,黄海量. 脑机接口对脑卒中后上肢运动功能效果的Meta分析[J]. 《中国康复理论与实践》, 2021, 27(7): 765-773.
LI Ling-ling,YU Ying,JIA Yu-qi,HUANG Hai-liang. Effect of Brain-computer Interface on Upper-limb Motor Function after Stroke: A Meta-analysis[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(7): 765-773.
表1
纳入文献的基本信息"
研究 | 国家 | n (E/C) | 年龄 (岁, E/C) | 病程 (E/C) | 干预措施 | 干预时间 | 干预周期 | 驱动设备 | 结局指标 | |
---|---|---|---|---|---|---|---|---|---|---|
E | C | |||||||||
Ang等2015[ | 新加坡 | 11/14 | (48.50±13.50)/(53.60±9.50) | (383.00±290.80) d/(234.70±183.80) d | BCI+常规康复训练 | 伪BCI+常规康复训练 | 90 min/d,3 d/周 | 4周 | 机器辅助设备 | ① |
Biasiucci等2018[ | 瑞士 | 14/13 | (56.36±9.91)/(59.00±12.36) | (39.79±45.90)个月/(33.46±30.51)个月 | BCI+常规康复训练 | 伪BCI+常规康复训练 | 60 min/d,2 d/周 | 5周 | 电刺激仪 | ① |
Chen等2020[ | 中国 | 7/7 | (41.60±12.00)/(52.00±11.10) | (3.10±1.70)个月/(3.90±1.50)个月 | BCI+常规康复训练 | 伪BCI+常规康复训练 | 3次/周 | 4周 | 机器辅助设备 | ① |
Frolov等2017[ | 俄罗斯 | 55/19 | (56.93±12.94)/(59.08±12.01) | (8.35±6.85)个月/(7.28±9.61)个月 | BCI+常规康复训练 | 伪BCI+常规康复训练 | 30 min/d,3 d/周 | 4周 | 机器辅助设备 | ①② |
Kim等2016[ | 美国 | 15/15 | (59.07±8.07)/(59.93±9.79) | (8.27±1.98)个月/(7.80±1.78)个月 | BCI+常规康复训练 | 常规康复训练 | 30 min/d,5 d/周 | 4周 | 电刺激仪 | ①④ |
Lee等2020[ | 韩国 | 13/13 | (55.15±11.57)/(58.30±9.19) | (7.46±1.61)个月/(8.30±1.97)个月 | BCI+常规康复训练 | 伪BCI+常规康复训练 | 30 min/d,5 d/周 | 4周 | 电刺激仪 | ①③④ |
Mihara等2013[ | 日本 | 10/10 | (56.10±7.90)/(60.10±8.50) | (146.60±36.20) d/(123.40±38.30) d | BCI+常规康复训练 | 伪BCI+常规康复训练 | 20 min/d,3 d/周 | 2周 | 视觉反馈装置 | ①② |
Pichiorri等2015[ | 意大利 | 14/14 | (64.10±8.40)/(59.60±12.70) | (2.70±1.70)个月/ (2.5±1.20)个月 | BCI+常规康复训练 | 伪BCI+常规康复训练 | 30 min/d,3 d/周 | 4周 | 视觉反馈装置 | ① |
任海等2020[ | 中国 | 30/30 | (41.77±8.65)/(40.70±8.15) | (32.85±4.99) d/ (33.85±3.73) d | BCI+常规康复训练 | 常规康复训练 | 40 min/d,5 d/周 | 4周 | 机器辅助设备 | ①③④ |
向宪文等2020[ | 中国 | 47/47 | (58.60±2.70)/(60.20±1.90) | (18.20±1.70) d/ (19.20±2.10) d | BCI+常规康复训练 | 常规康复训练 | 45 min/d,2周为1个疗程,疗程间休息3 d | 7周 | 电刺激仪 | ①④ |
张洺华等2020[ | 中国 | 15/15 | (60.93±6.76)/(57.87±8.61) | (3.02±1.36)个月/(3.44±1.55)个月 | BCI+常规康复训练 | 伪BCI+常规康复训练 | 20 min/d,5 d/周 | 8周 | 电刺激仪 | ①④ |
徐英等2018[ | 中国 | 16/16 | (72.43±8.56)/(76.81±9.57) | 未提供 | BCI+常规康复训练 | 伪BCI+常规康复训练 | 30 min/d,3 d/周 | 8周 | 电刺激仪 | ①④ |
李明芬等2012[ | 中国 | 7/7 | (66.29±4.89)/(66.00±6.30) | 未提供 | BCI+常规康复训练 | 常规康复训练 | 90 min/d,3 d/周 | 8周 | 电刺激仪 | ①② |
梁思捷等2020[ | 中国 | 15/15 | (50.60±13.46)/(57.94±8.84) | (3.00±2.98)个月/(2.93±1.44)个月 | BCI+常规康复训练 | 伪BCI+常规康复训练 | 30 min/d,5 d/周 | 4周 | 机器辅助设备 | ①④ |
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