脑机接口控制的功能性电刺激对脑卒中患者上肢功能障碍的康复效果

doi:10.3969/j.issn.1006-9771.2021.07.011

《中国康复理论与实践》 ›› 2021, Vol. 27 ›› Issue (7): 802-806.doi: 10.3969/j.issn.1006-9771.2021.07.011

脑机接口控制的功能性电刺激对脑卒中患者上肢功能障碍的康复效果

唐千乇^1,²,张通^1,²()

1.首都医科大学康复医学院,北京市 100068
2.中国康复研究中心北京博爱医院,北京市 100068

收稿日期:2021-03-12 修回日期:2021-06-12 出版日期:2021-07-25 发布日期:2021-07-28
通讯作者: 张通 E-mail:tom611@126.com
作者简介:唐千乇(1988-),男,汉族,江苏靖江市人,硕士研究生,主要研究方向：机器人康复、脑机接口。|张通(1961-),男,汉族,北京市人,主任医师,教授,博士生导师,主要研究方向：神经康复、神经病学。
基金资助:
1.国家自然科学基金项目(U1613228);2.中国康复研究中心项目(2019-HZ-07)

Effects of Functional Electrical Stimulation Controlled by Brain-computer Interface on Upper Limb Dysfunction in Stroke Patients

TANG Qian-tuo^1,²,ZHANG Tong^1,²()

1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
2. Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China

Received:2021-03-12 Revised:2021-06-12 Published:2021-07-25 Online:2021-07-28
Contact: ZHANG Tong E-mail:tom611@126.com
Supported by:
National Science Foundation of China(U1613228);China Rehabilitation Research Centre Project(2019-HZ-07)

摘要/Abstract

摘要：

目的观察脑机接口控制的功能性电刺激对脑卒中后上肢运动功能障碍的影响。

方法 2019年7月至2020年11月,本院神经康复科住院脑卒中患者34例随机分为对照组(n = 17)和试验组(n = 17),分别接受单纯功能性电刺激和脑机接口控制的功能性电刺激。治疗前后分别比较两组患侧肘关节反应时间、肘关节位置觉误差、Fugl-Meyer评定量表上肢部分(FMA-UE)、改良Barthel指数(MBI)和事件相关去同步化(ERD)强度进行评价。

结果两组患侧肘关节反应时间、肘关节位置觉误差、FMA-UE、MBI评分和ERD强度均有所改善(F > 10.825, |Z| > 3.624, P < 0.05),且试验组优于对照组(F > 5.853, |Z| > 3.201, P < 0.05)。

结论脑机接口控制的功能性电刺激对脑卒中患者上肢功能障碍的康复具有积极作用。

关键词: 脑卒中, 运动想象, 脑机接口, 功能性电刺激

Abstract:

Objective To observe the effects of functional electrical stimulation (FES) controlled by brain-computer interface on upper limb motor dysfunction in stroke patients.

Methods From July, 2019 to November, 2020, 34 stroke patients hospitalized in neurological rehabilitation department were randomly divided into control group (n = 17) and experimental group (n = 17). They were treated with simple FES and FES controlled by brain-computer interface, respectively. The reaction time, joint position error of elbow joint, the scores of Fugl-Meyer Assessment-Upper Extremity (FMA-UE), modified Barthel Index (MBI) and event-related desynchronization (ERD) powers of affected upper limb were evaluated before and after intervention.

Results After intervention, the reaction time, joint position error of the elbow joint, the scores of FMA, MBI and ERD power of the affected elbow joint improved in both groups (F > 10.825, |Z| > 3.624, P < 0.05), and they were better in the experimental group than in the control group (F > 5.853, |Z| > 3.201, P < 0.05).

Conclusion FES controlled by brain-computer interface is positive on the rehabilitation of stroke patients with upper limb dysfunction.

Key words: stroke, motor imagery, brain-computer interface, functional electrical stimulation

中图分类号:

R743.3

唐千乇,张通. 脑机接口控制的功能性电刺激对脑卒中患者上肢功能障碍的康复效果[J]. 《中国康复理论与实践》, 2021, 27(7): 802-806.

TANG Qian-tuo,ZHANG Tong. Effects of Functional Electrical Stimulation Controlled by Brain-computer Interface on Upper Limb Dysfunction in Stroke Patients[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(7): 802-806.

图/表 6

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参考文献 26

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组别	n	性别(男/女,n)	年龄(岁)	病程(d)	MMSE评分
对照组	17	11/6	51.27±8.56	50.87±14.87	27.43±0.43
试验组	17	12/5	49.93±8.82	51.53±15.43	27.32±0.54
χ²/t值		0.171	0.796	0.116	0.277
P值		0.679	0.436	0.908	0.784

组别	治疗前	治疗后	F值	P值
对照组	303.75±30.98	277.41±28.50	13.393	0.002
试验组	293.29±30.02	259.25±21.17	15.672	0.001
F值	1.136	5.853
P值	0.302	0.028

组别	治疗前	治疗后	F值	P值
对照组	7.30±0.67	6.70±0.61	10.825	0.005
试验组	7.01±0.58	5.96±1.01	16.662	0.001
F值	2.634	7.212
P值	0.124	0.016

组别	治疗前	治疗后	Z值	P值
对照组	31.94±2.56	44.70±2.36	-3.624	< 0.001
试验组	32.05±2.10	48.52±3.28	-3.625	< 0.001
Z值	-0.070	-3.201
P值	0.944	0.001

组别	治疗前	治疗后	Z值	P值
对照组	55.35±2.99	72.70±3.75	-3.628	< 0.001
试验组	52.23±3.25	78.65±4.92	-3.625	< 0.001
Z值	-1.199	-3.391
P值	0.230	0.001

脑机接口控制的功能性电刺激对脑卒中患者上肢功能障碍的康复效果

Effects of Functional Electrical Stimulation Controlled by Brain-computer Interface on Upper Limb Dysfunction in Stroke Patients

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组别	治疗前	治疗后	F值	P值
对照组	12.21±1.69	13.49±1.16	16.970	0.001
试验组	13.12±1.51	15.00±1.35	15.555	0.001
F值	3.645	10.748
P值	0.074	0.005

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