运动训练对脑缺血再灌注大鼠认知功能及前额皮层神经元核抗原和突触素1表达的效果

doi:10.3969/j.issn.1006-9771.2021.11.006

《中国康复理论与实践》 ›› 2021, Vol. 27 ›› Issue (11): 1272-1281.doi: 10.3969/j.issn.1006-9771.2021.11.006

运动训练对脑缺血再灌注大鼠认知功能及前额皮层神经元核抗原和突触素1表达的效果

凌梦钰^1,²,杨一卓²,刘帅²,叶超群^1,²()

1.安徽医科大学空军临床学院,北京市 100142
2.空军特色医学中心康复科,北京市 100142

收稿日期:2021-06-05 修回日期:2021-07-28 出版日期:2021-11-25 发布日期:2021-12-03
通讯作者: 叶超群 E-mail:yechaoqun@sina.com
作者简介:凌梦钰(1994-),女,汉族,安徽合肥市人,硕士研究生,主要研究方向：康复医学与理疗学。|叶超群,博士,主任医师、教授。
基金资助:
中央军委后勤科研重点项目(BKJ17J006)

Effect of Exercise on Expression of NeuN and SynapsinI in Cortex and Cognitive Function in Rats after Cerebral Ischemia-reperfusion

LING Meng-yu^1,²,YANG Yi-zhuo²,LIU Shuai²,YE Chao-qun^1,²()

1. Air Force Clinical College, Anhui Medical University, Beijing 100142, China
2. Department of Rehabilitation, Air Force Medical Center, Beijing 100142, China

Received:2021-06-05 Revised:2021-07-28 Published:2021-11-25 Online:2021-12-03
Contact: YE Chao-qun E-mail:yechaoqun@sina.com
Supported by:
Central Military Commission Logistics Scientific Research(Key)(BKJ17J006)

摘要/Abstract

摘要：

目的观察运动训练对脑缺血再灌注损伤大鼠认知功能及前额皮层神经元核抗原(NeuN)和突触素1 (SynapsinI)表达的影响,探究运动对缺血再灌注后认知功能改善的机制。方法雄性Sprague-Dawley大鼠40只随机数字表法分成假手术组(S组)、模型组(M组)、假手术跑台组(SE组)和模型跑台组(ME组),每组10只。线栓法制备左侧大脑中动脉栓塞1 h再灌注模型,SE组和ME组行跑台训练14 d。训练后,采用旷场实验和新物体识别实验评价大鼠认知功能;尼氏染色和免疫荧光染色观察大鼠前额皮质中神经细胞的数量及分布情况,通过ELISA观察血清SynapsinI表达。结果与S组相比,M组旷场实验活跃度、穿格次数、总距离、中央区域活动时间,新物体识别实验认知指数和总距离均下降(P < 0.05);与M组相比,ME组旷场实验活跃度、穿格次数、总距离、中央区域活动时间及新物体识别实验认知指数和总距离均提高(P < 0.05)。M组较S组尼氏体计数减少(P < 0.05),排列紊乱;ME组较M组尼氏体数量增多(P < 0.05);M组NeuN阳性细胞数表达较S组降低(P < 0.05),ME组较M组增加(P < 0.05);M组SynapsinI阳性细胞数较S组降低(P < 0.05),ME组较M组增加(P < 0.05);M组血清SynapsinI表达较S组降低(P < 0.05),ME组较M组增加(P < 0.05);行为学实验结果多与尼氏体、NeuN、SynapsinI表达量呈正相关(r > 0.221, P < 0.05)。结论脑缺血再灌注会导致大鼠认知功能损伤,运动训练能减轻神经损伤,改善认知功能,可能与促进NeuN和SynapsinI表达,增加前额皮质神经元和突触数量有关。

关键词: 缺血再灌注, 认知障碍, 运动训练, 突触素1, 神经元核抗原, 大鼠

Abstract:

Objective To observe the effect of exercise on cognitive function and the expression of NeuN and SynapsinI in prefrontal cortex of rats after cerebral ischemia-reperfusion. Methods Forty health male Sprague-Dawley rats were randomly divided into sham group (S group, n = 10), model group (M group, n = 10), sham & exercise group (SE group, n = 10) and model & exercise group (ME group, n = 10). The left middle cerebral artery was occluded for one hour and reperfused. SE and ME groups accepted treadmill training, for 14 days. The cognitive function of rats was evaluated with open field experiment and new object recognition experiment. The number and distribution of nerve cells in rat brain were observed with Nissl staining and immunofluorescence staining. The SynapsinI expression in serum was detected with ELISA.Results Compared with S group, the activity, times of crossing, length and activity time in central area of open field experiment decreased in M group, as well as the cognitive index and length of new object recognition experiment (P < 0.05). Compared with M group, all the indexes increased in ME group (P < 0.05). The number of Nissl bodies decreased in M group (P < 0.05) and the arrangement was disordered, while the number of Nissl bodies increased in ME group (P < 0.05) compared with M group. The NeuN positive cells was more in S group than in M group (P < 0.05), and it was more in ME group than in M group (P < 0.05); as well as that of SynapsinI. The expression of SynapsinI decreased in M group (P < 0.05), and increased in ME group (P < 0.05). Most results of behavioral experiments positively correlated with the expression of Nissl, NeuN and SynapsinI (r > 0.221, P < 0.05).Conclusion Cerebral ischemia-reperfusion can cause cognitive impairment in rats. Exercise can alleviate nerve injury and improve cognitive function, which may relate to promoting the expression of NeuN and SynapsinI in prefrontal cortex, to increase the number of neurons and synapses.

Key words: ischemia-reperfusion, cognitive impairment, exercise, SynapsinI, NeuN, rats

凌梦钰,杨一卓,刘帅,叶超群. 运动训练对脑缺血再灌注大鼠认知功能及前额皮层神经元核抗原和突触素1表达的效果[J]. 《中国康复理论与实践》, 2021, 27(11): 1272-1281.

LING Meng-yu,YANG Yi-zhuo,LIU Shuai,YE Chao-qun. Effect of Exercise on Expression of NeuN and SynapsinI in Cortex and Cognitive Function in Rats after Cerebral Ischemia-reperfusion[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2021, 27(11): 1272-1281.

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运动方案	第1~3天	第4~10天	第11~17天
初运动	3 m/min, 10 s	3 m/min, 10 s	5 m/min, 10 s
一级运动	5 m/min, 20 s	8 m/min, 20 s	10 m/min, 20 s
二级运动	5 m/min, 5 min	12 m/min, 30 min	15 m/min, 30 min

组别	1 d	3 d	7 d	10 d	14 d	17 d	F值	P值
S组	0	0	0	0	0	0	0	1
SE组	0	0	0	0	0	0	0	1
M组	1.88±0.64	2.25±0.46	2.13±0.35	1.75±0.71	1.13±0.35	0.75±0.46	6.298	0.004
ME组	1.86±0.71	2.09±1.22	1.46±0.69	0.91±0.54	0.55±0.52	0.27±0.47	11.257	< 0.001
F值^a	0.056	0.121	6.318	8.687	7.341	4.871
P值^a	0.99	0.815	0.022	0.009	0.015	0.041

组别	n	术前	3 d	7 d	10 d	14 d	17 d	F值	P值
S组	10	215.4±3.6	234.7±6.1	260.5±5.4	282.3±7.7	312.3±11.6	343.4±14.2	145.358	< 0.001
SE组	10	216.7±3.1	232.3±4.8	268.4±6.4	288.3±8.7	318.5±10.5	349.0±11.5	195.322	< 0.001
M组	10	215.9±2.9	203.0±22.8^a	219.8±26.1^a	237.1±29.3^a	256.4±32.2^a	289.2±34.5^a	9.343	< 0.001
ME组	10	218.1±2.5	204.0±18.1	229.2±19.1	248.2±23.6^b	280.1±28.2^b	312.4±29.0^b	18.811	< 0.001
F值		0.739	9.961	14.996	10.781	9.452	9.475
P值		0.544	0.001	< 0.001	< 0.001	0.001	0.001

组别	n	穿格次数	总距离(mm)	中央区域活动时间(s)
S组	10	41.20±7.20	2136.40±432.15	3.92±1.08
SE组	10	41.60±8.23	2255.20±369.01	3.49±1.39
M组	10	22.60±7.16^a	935.40±116.35^a	0.14±0.22^a
ME组	10	22.80±8.01^b	926.60±142.052^b	0.15±0.26^b
F值		21.837	37.99	26.728
P值		< 0.001	< 0.001	< 0.001

组别	n	活跃度	穿格次数	总距离(mm)	中央区域活动时间(s)
S组	10	29.79±3.86	55.83±7.20	2788.56±433.86	4.89±1.24
SE组	10	43.14±7.10^a	58.17±9.82	2977.66±225.81^a	7.92±1.76^a
M组	10	12.71±2.55^a	23.83±11.60^a	1319.33±447.95^a	1.11±0.94^a
ME组	10	26.07±1.42^b	50.67±20.70^b	2746.01±616.79^b	4.06±1.41^b
F值		42.222	7.056	14.294	25.067
P值		< 0.001	0.002	< 0.001	< 0.001

运动训练对脑缺血再灌注大鼠认知功能及前额皮层神经元核抗原和突触素1表达的效果

Effect of Exercise on Expression of NeuN and SynapsinI in Cortex and Cognitive Function in Rats after Cerebral Ischemia-reperfusion

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组别	n	CI	总距离(mm)
S组	10	0.68±0.04	10051.75±4094.99
SE组	10	0.80±0.04	15163.41±3226.99^a
M组	10	0.41±0.07^a	5077.68±1096.70^a
ME组	10	0.74±0.05^b	8839.58±895.08^b
F值		64.482	27.895
P值		< 0.001	< 0.001

组别	n	尼氏体计数
S组	10	78.00±6.04
SE组	10	88.4±6.50^a
M组	10	41.8±3.49^a
ME组	10	63.2±6.42^b
F值		61.80
P值		< 0.001

组别	n	NeuN	SynapsinI
S组	10	74.6±4.50	33.20±7.16
SE组	10	94.8±8.056.91^a	46.60±6.23^a
M组	10	53.4±4.76^a	16.8±5.22^a
ME组	10	64.6±7.20^b	47.00±7.68^b
F值		35.590	23.072
P值		< 0.001	< 0.001

组别	n	SynapsinI血清蛋白浓度
S组	10	166.90±6.58
SE组	10	187.35±22.90
M组	10	134.22±7.72^a
ME组	10	260.85±34.48^b
F值		31.734
P值		< 0.001

项目	穿格次数	总距离	中央区域活动时间	认知指数	尼氏体计数	NeuN	SynapsinI	血清SynapsinI
活跃度	0.611^a	0.731^c	0.882^c	0.830^c	0.855^c	0.221^b	0.720^b	0.362^c
穿格次数	-	0.932^c	0.622^b	0.725^c	0.547^a	0.060^a	0.721^c	0.548^a
总距离		-	0.664^b	0.836^c	0.651^b	0.620^a	0.831^c	0.603^b
中央区域活动时间			-	0.821^c	0.814^c	0.219	0.685^b	0.301^a
认知指数				-	0.835^c	0.580^a	0.891^c	0.613^b
尼氏体计数					-	0.338^b	0.631^a	0.270
NeuN						-	0.320^a	0.739^c
SynapsinI							-	0.761^c

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