经颅直流电刺激改善卒中后失语的系统综述

doi:10.3969/j.issn.1006-9771.2022.05.008

《中国康复理论与实践》 ›› 2022, Vol. 28 ›› Issue (5): 534-543.doi: 10.3969/j.issn.1006-9771.2022.05.008

经颅直流电刺激改善卒中后失语的系统综述

陈雅婷^1,²,张劼²,张优媚³,张双双^1,²,叶祥明²()

1.蚌埠医学院研究生院,安徽蚌埠市 233030
2.浙江省人民医院康复医学科,浙江杭州市 310014
3.浙江中医药大学第三临床医学院,浙江杭州市 310053

收稿日期:2022-02-13 修回日期:2022-04-29 出版日期:2022-05-25 发布日期:2022-06-10
通讯作者: 叶祥明 E-mail:yexmdr@126.com
作者简介:陈雅婷(1994-),女,汉族,湖南常德市人,硕士,医师,主要研究方向：卒中后失语。
基金资助:
浙江省自然科学基金项目(LGF20H170011);浙江省自然科学基金项目(LGF22H170003)

Effects transcranial direct current stimulation on post-stroke aphasia: a systematic review

CHEN Yating^1,²,ZHANG Jie²,ZHANG Youmei³,ZHANG Shuangshuang^1,²,YE Xiangming²()

1. Bengbu Medical University, Bengbu, Anhui 233030, China
2. Zhejiang Provential People's Hospital, Hangzhou, Zhejiang 310014, China
3. Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China

Received:2022-02-13 Revised:2022-04-29 Published:2022-05-25 Online:2022-06-10
Contact: YE Xiangming E-mail:yexmdr@126.com
Supported by:
Zhejiang Natural Science Foundation(LGF20H170011);Zhejiang Natural Science Foundation(LGF22H170003)

摘要/Abstract

摘要：

目的系统评价经颅直流电刺激(tDCS)对卒中后失语症(PSA)的治疗作用。方法在PubMed、Web of Science、Cochrane Library、Embase、中国知网和万方数据库中检索tDCS治疗卒中后失语的相关文献,检索时间为建库至2021年12月。提取相关内容进行系统综述。结果共返回文献1 026篇,最终纳入45篇,发表时间为2010年至2021年,研究对象为卒中后失语患者,主要结局指标为言语量表和各子项。大部分研究治疗组治疗后言语量表评分高于对照组,少数波士顿失语症检查中未见改善,或仅复杂语言任务有改善。tDCS能改善卒中后失语患者的复述、命名、拼写、言语流畅度等。影响患者恢复的因素可能有电极位置、电流、持续时间、强度和左侧皮质完整性。结论 tDCS治疗PSA对不同语言子项均有效果;不同tDCS方案对不同语言功能的效果有所差异。

关键词: 脑卒中, 失语, 经颅直流电刺激, 系统综述

Abstract:

Objective To evaluate the effects of transcranial direct current stimulation (tDCS) on post-stroke aphasia (PSA). Methods Literatures about tDCS for PSA were retrieved from PubMed, Web of Science, Cochrane library, Embase CNKI and Wanfang Data, until December, 2021. The contents of the author, publication time, subjects, intervention methods and time, main outcome indicators and conclusions were extracted. Results A total of 1 026 articles were returned and 45 articles were finally included. The publication time was from 2010 to 2021. The subjects of the study were patients with PSA. The main outcome indicators were the various speech scales and their sub-items. For most of the trials, scores of the scales were better in the experimental groups than in the control groups after treatment, and a few found little improvement in Boston Diagnostic Aphasia Examination, or only improved in complex language tasks. tDCS can improve the repetition, naming, spelling and verbal fluency of PSA patients, which might relate with electrode placement, current magnitude, duration, intensity and left cortical integrity. Conclusion tDCS is effective on different language sub-items of PSA, and various with the program of tDCS.

Key words: stroke, aphasia, transcranial direct current stimulation, systematic review

中图分类号:

R743.3

陈雅婷,张劼,张优媚,张双双,叶祥明. 经颅直流电刺激改善卒中后失语的系统综述[J]. 《中国康复理论与实践》, 2022, 28(5): 534-543.

CHEN Yating,ZHANG Jie,ZHANG Youmei,ZHANG Shuangshuang,YE Xiangming. Effects transcranial direct current stimulation on post-stroke aphasia: a systematic review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(5): 534-543.

图/表 4

图1

表1

纳入文献的一般情况"

研究	刺激电极	刺激部位	评估工具	结果
Branscheidt等^[16](2018)	阳极	左初级运动皮质	词汇决策任务,简单反应时间任务	提高词汇判断的准确率
Campana等^[13](2015)	阳极	左额下回	语言测验	疗效取决于左侧皮质解剖完整性
Cherney等^[17](2021)	阳极/阴极	个性化刺激部位	西方失语成套测验,交际有效性指数	促进语言皮质激活
Cipollari等^[18](2015)	阳极	右额下回	西方失语成套测验	言语功能改善
Darkow等^[9](2017)	阳极	左初级运动皮质	独立成分分析	增强命名网络的活动性和连通性
Feil等^[19](2019)	阳极	双额下回	学习适应性测验/标记测验	图片命名改善(名词数量增加)
Fiori等^[20](2013)	阳极	左额下回/左Wernicke	标记测验	颞区名词命名改善明显,额区动词命名改善明显
Fiori等^[21](2019)	阴极	右额下回Broca同源区	动词检索任务	2 mA组动词命名改善
Flöel等^[22](2011)	阳极/阴极	右颞顶皮质	学习适应性测验	命名能力提高
Fridriksson等^[23](2018)	阳极	左具有最高命名相关激活性的颞叶区域(Wernicke区附近)	费城命名量表	命名正确率提高
Guillouët等^[24](2020)	阳极/阴极	双额下回	波士顿诊断性失语症检查(法语改编版)	没有明显改善
Ihara等^[25](2020)	阳极	左额下回	命名任务+造句任务	命名正确率、未训练词的相关词句的产生改善
Kang等^[26](2011)	阴极	右额下回	波士顿诊断性失语症检查	图片命名改善
Keser等^[27](2017)	阳极	右额下回	西方失语成套测验	言语和语言能力改善
Kurfeß等^[28](2020)	阳极	左额下回	命名测验	组间无显著性差异
Marangolo等^[29](2013)a	阳极	左额下回/左Wernicke区	标记测验,名词和动词命名	改善信息性言语
Marangolo等^[30](2013)b	阳极	左额下回/左Wernicke区	标记测验,波士顿诊断性失语症检查	促进动词提取缺陷恢复
Marangolo等^[31](2014)	阳极/阴极	双额下回	图片描述,名词和动词命名	图片描述、名词和动词命名恢复
Marangolo等^[11](2016)	阳极/阴极	双额下回(左阳极,右阴极)	图片描述任务,名词和单词重复	增加受损半球的功能连接,促进言语功能恢复
Marangolo等^[32](2018)	阴极	右小脑	动词命名/生成任务	复杂的语言任务改善
Meinzer等^[33](2016)	阳极	左初级运动皮质	合作伙伴沟通问卷	命名改善,效果持续
Monti等^[34](2008)	阳极/阴极	左额下回	图片命名任务	图片命名任务准确率提高
Norise等^[35](2017)	阳极/阴极	左额颞叶	改良波士顿诊断性失语症检查	单词水平流利度提高
Pestalozzi等^[36](2018)	阳极/假刺激	左DLPFC	波士顿诊断性失语症检查,失语障碍量表	词汇提取加工改善
Pisano等^[37](2021)	阳极/阴极	双颞顶皮质	语言测验	写作能力改善
Polanowska等^[38](2013)a	阳极	左额下回后部	波士顿诊断性失语症检查	组间无显著性差异
Polanowska等^[39](2013)b	阳极	左额下回	波士顿诊断性失语症检查	组间无显著性差异
Richardson等^[40](2015)	阳极/阴极	功能影像定位	命名准确性和响应时间	命名准确率和响应时间提高
Shah-Basak等^[41](2015)	阳极/阴极	双前额叶	西方失语成套测验	图片命名改善
Shah-Basak等^[42](2020)	阳极/阴极	个性化刺激部位	西方失语成套测验,波士顿诊断性失语症检查,图片词汇测试,延迟单词阅读任务	复述准确率提高
Silva等^[43](2018)	阴极	右额下回	波士顿诊断性失语症检查,命名测验	策略正确响应平均时间降低
Spielmann等^[44](2018)a	阳极	左额下回/左颞上回后部	训练/未训练项目命名准确性	言语功能分提高
Spielmann等^[45](2018)b	阳极	左额下回	波士顿诊断性失语症检查,失语症严重程度评定量表,日常语言测试,标记测验	组间无显著差异
Vila-Nova等^[47](2019)	阳极	左额下回	图片命名任务,音节重复测试	发音准确度提高
Volpato等^[48](2013)	阳极	左额下回	学习适应性测验,物品和动词命名评估	未见显著改善
You等^[49](2011)	阳极/阴极	双颞上回后部	西方失语成套测验	听理解改善
Zhao等^[50](2021)	阳极	左额下回	西方失语成套测验	失语商增加
陶媛媛等^[46](2019)	阳极	左额下回	西方失语成套测验	视觉和听觉通道的命名能力改善
魏雅萍等^[51](2016)	阳极/假刺激	左Broca或Wernicke区	图片命名	图命名准确率提高
方翠霓等^[52](2017)	阳极	左Broca或Wernicke区	改良波士顿诊断性失语症检查,日常生活交流能力检查量表	语言能力改善
张芹等^[53](2017)	阳极/假刺激	左Broca区	图片命名,西方失语成套测验	言语流畅度和命名能力提高
张洪等^[54](2017)	阳极/假刺激	左额下回三角部区阳极刺激、右额下回三角部区阴极刺激	西方失语成套测验	自发言语、复述、命名成绩提高
汪洁等^[55](2018)	阳极	左Broca或Wernicke区	图片命名	治疗项、非治疗项图命名成绩均有改善
王玲等^[56](2018)	阳极	左大脑Broca区	西方失语成套测验	失语商提高,言语功能改善,且存在持续效应
潘巍一等^[57](2021)	阳极	左大脑Broca区	改良波士顿诊断性失语症检查	语言功能恢复,运动性失语改善

表1

表2

图2

参考文献 67

[1]	ENGELTER S T, GOSTYNSKI M, PAPA S, et al. Epidemiology of aphasia attributable to first ischemic stroke: incidence, severity, fluency, etiology, and thrombolysis[J]. Stroke, 2006, 37(6): 1379-1384. doi: 10.1161/01.STR.0000221815.64093.8c
[2]	BERUBE S, HILLIS A E. Advances and innovations in aphasia treatment trials[J]. Stroke, 2019, 50(10): 2977-2984. doi: 10.1161/STROKEAHA.119.025290
[3]	PASCUAL-LEONE A, GATES J R, DHUNA A. Induction of speech arrest and counting errors with rapid-rate transcranial magnetic stimulation[J]. Neurology, 1991, 41(5): 697-702. doi: 10.1212/WNL.41.5.697
[4]	BIKSON M, GROSSMAN P, THOMAS C, et al. Safety of transcranial direct current stimulation: evidence based update 2016 [J]. Brain Stimul, 2016, 9(5): 641-661. doi: 10.1016/j.brs.2016.06.004
[5]	NITSCHE M A, FRICKE K, HENSCHKE U, et al. Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans[J]. J Physiol, 2003, 553(Pt 1): 293-301. doi: 10.1113/jphysiol.2003.049916
[6]	HOLLAND R, CRINION J. Can tDCS enhance treatment of aphasia after stroke?[J]. Aphasiology, 2012, 26(9): 1169-1191. doi: 10.1080/02687038.2011.616925
[7]	FRIDRIKSSON J, ELM J, STARK B C, et al. BDNF genotype and tDCS interaction in aphasia treatment[J]. Brain Stimul, 2018, 11(6): 1276-1281. doi: 10.1016/j.brs.2018.08.009
[8]	FRITSCH B, REIS J, MARTINOWICH K, et al. Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning[J]. Neuron, 2010, 66(2): 198-204. doi: 10.1016/j.neuron.2010.03.035
[9]	DARKOW R, MARTIN A, WURTZ A, et al. Transcranial direct current stimulation effects on neural processing in post-stroke aphasia[J]. Hum Brain Mapp, 2017, 38(3): 1518-1531. doi: 10.1002/hbm.23469
[10]	ROSSO C, PERLBARG V, VALABREGUE R, et al. Broca's area damage is necessary but not sufficient to induce after-effects of cathodal tDCS on the unaffected hemisphere in post-stroke aphasia[J]. Brain Stimul, 2014, 7(5): 627-635. doi: 10.1016/j.brs.2014.06.004
[11]	MARANGOLO P, FIORI V, SABATINI U, et al. Bilateral transcranial direct current stimulation language treatment enhances functional connectivity in the left hemisphere: preliminary data from aphasia[J]. J Cogn Neurosci, 2016, 28(5): 724-738. doi: 10.1162/jocn_a_00927
[12]	HARTWIGSEN G, SAUR D. Neuroimaging of stroke recovery from aphasia: insights into plasticity of the human language network[J]. Neuroimage, 2019, 190: 14-31. doi: 10.1016/j.neuroimage.2017.11.056
[13]	CAMPANA S, CALTAGIRONE C, MARANGOLO P. Combining voxel-based lesion-symptom mapping (VLSM) with A-tDCS language treatment: predicting outcome of recovery in nonfluent chronic aphasia[J]. Brain Stimul, 2015, 8(4): 769-776. doi: 10.1016/j.brs.2015.01.413
[14]	SEBASTIAN R, SAXENA S, TSAPKINI K, et al. Cerebellar tDCS: a novel approach to augment language treatment post-stroke[J]. Front Hum Neurosci, 2016, 10: 695. doi: 10.3389/fpsyg.2019.00695
[15]	STERNE J A C, SAVOVIĆ J, PAGE M J, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials[J]. BMJ, 2019, 366: 14898.
[16]	BRANSCHEIDT M, HOPPE J, ZWITSERLOOD P, et al. tDCS over the motor cortex improves lexical retrieval of action words in poststroke aphasia[J]. J Neurophysiol, 2018, 119(2): 621-630. doi: 10.1152/jn.00285.2017
[17]	CHERNEY L R, BABBITT E M, WANG X, et al. Extended fMRI-guided anodal and cathodal transcranial direct current stimulation targeting perilesional areas in post-stroke aphasia: a pilot randomized clinical trial[J]. Brain Sci, 2021, 11(3): 306. doi: 10.3390/brainsci11030306
[18]	CIPOLLARI S, VENIERO D, RAZZANO C, et al. Combining TMS-EEG with transcranial direct current stimulation language treatment in aphasia[J]. Expert Rev Neurother, 2015, 15(7): 833-845. doi: 10.1586/14737175.2015.1049998
[19]	FEIL S, EISENHUT P, STRAKELJAHN F, et al. Left shifting of language related activity induced by bihemispheric tDCS in postacute aphasia following stroke[J]. Front Neurosci, 2019, 13: 295. doi: 10.3389/fnins.2019.00295
[20]	FIORI V, CIPOLLARI S, DI PAOLA M, et al. tDCS stimulation segregates words in the brain: evidence from aphasia[J]. Front Hum Neurosci, 2013, 7: 269.
[21]	FIORI V, NITSCHE M A, CUCUZZA G, et al. High-definition transcranial direct current stimulation improves verb recovery in aphasic patients depending on current intensity[J]. Neuroscience, 2019, 406: 159-166. doi: 10.1016/j.neuroscience.2019.03.010
[22]	FLÖEL A, MEINZER M, KIRSTEIN R, et al. Short-term anomia training and electrical brain stimulation[J]. Stroke, 2011, 42(7): 2065-2067. doi: 10.1161/STROKEAHA.110.609032
[23]	FRIDRIKSSON J, RORDEN C, ELM J, et al. Transcranial direct current stimulation vs sham stimulation to treat aphasia after stroke: a randomized clinical trial[J]. JAMA Neurol, 2018, 75(12): 1470-1476. doi: 10.1001/jamaneurol.2018.2287
[24]	GUILLOUËT E, COGNÉ M, SAVEROT E, et al. Impact of combined transcranial direct current stimulation and speech-language therapy on spontaneous speech in aphasia: a randomized controlled double-blind study[J]. J Int Neuropsychol Soc, 2020, 26(1): 7-18. doi: 10.1017/S1355617719001036
[25]	IHARA A S, MIYAZAKI A, IZAWA Y, et al. Enhancement of facilitation training for aphasia by transcranial direct current stimulation[J]. Front Hum Neurosci, 2020, 14: 573459. doi: 10.3389/fnhum.2020.573459
[26]	KANG E K, KIM Y K, SOHN H M, et al. Improved picture naming in aphasia patients treated with cathodal tDCS to inhibit the right Broca's homologue area[J]. Restor Neurol Neurosci, 2011, 29(3): 141-152.
[27]	KESER Z, DEHGAN M W, SHADRAVAN S, et al. Combined dextroamphetamine and transcranial direct current stimulation in poststroke aphasia[J]. Am J Phys Med Rehabil, 2017, 96(10 Suppl 1): S141-S145.
[28]	KURFEß C. Effekte der transkraniellen Gleichstromstimulation auf das benennen und die spontansprache von aphasie-patienten[J]. Neurol Rehabil, 2020, 26(2): 93-103.
[29]	MARANGOLO P, FIORI V, CALPAGNANO M A, et al. tDCS over the left inferior frontal cortex improves speech production in aphasia[J]. Front Hum Neurosci, 2013, 7: 539.
[30]	MARANGOLO P, FIORI V, DI PAOLA M, et al. Differential involvement of the left frontal and temporal regions in verb naming: a tDCS treatment study[J]. Restor Neurol Neurosci, 2013, 31(1): 63-72.
[31]	MARANGOLO P, FIORI V, GELFO F, et al. Bihemispheric tDCS enhances language recovery but does not alter BDNF levels in chronic aphasic patients[J]. Restor Neurol Neurosci, 2014, 32(2): 367-379.
[32]	MARANGOLO P, FIORI V, CALTAGIRONE C, et al. Transcranial cerebellar direct current stimulation enhances verb generation but not verb naming in poststroke aphasia[J]. J Cogn Neurosci, 2018, 30(2): 188-199. doi: 10.1162/jocn_a_01201
[33]	MEINZER M, DARKOW R, LINDENBERG R, et al. Electrical stimulation of the motor cortex enhances treatment outcome in post-stroke aphasia[J]. Brain, 2016, 139(Pt 4): 1152-1163. doi: 10.1093/brain/aww002
[34]	MONTI A, COGIAMANIAN F, MARCEGLIA S, et al. Improved naming after transcranial direct current stimulation in aphasia[J]. J Neurol Neurosurg Psychiatry, 2008, 79(4): 451-453. doi: 10.1136/jnnp.2007.135277
[35]	NORISE C, SACCHETTI D, HAMILTON R. Transcranial direct current stimulation in post-stroke chronic aphasia: the impact of baseline severity and task specificity in a pilot sample[J]. Front Hum Neurosci, 2017, 11: 260.
[36]	PESTALOZZI M I, DI PIETRO M, MARTINS GAYTANIDIS C, et al. Effects of prefrontal transcranial direct current stimulation on lexical access in chronic poststroke aphasia[J]. Neurorehabil Neural Repair, 2018, 32(10): 913-923. doi: 10.1177/1545968318801551
[37]	PISANO F, CALTAGIRONE C, INCOCCIA C, et al. DUAL-tDCS treatment over the temporo-parietal cortex enhances writing skills: first evidence from chronic post-stroke aphasia[J]. Life (Basel), 2021, 11(4): 343.
[38]	POLANOWSKA K E, LESNIAK M M, SENIOW J B, et al. Anodal transcranial direct current stimulation in early rehabilitation of patients with post-stroke non-fluent aphasia: a randomized, double-blind, sham-controlled pilot study[J]. Restor Neurol Neurosci, 2013, 31(6): 761-771.
[39]	POLANOWSKA K E, LESNIAK M, SENIOW J B, et al. No effects of anodal transcranial direct stimulation on language abilities in early rehabilitation of post-stroke aphasic patients[J]. Neurol Neurochir Pol, 2013, 47(5): 414-422. doi: 10.5114/ninp.2013.38221
[40]	RICHARDSON J, DATTA A, DMOCHOWSKI J, et al. Feasibility of using high-definition transcranial direct current stimulation (HD-tDCS) to enhance treatment outcomes in persons with aphasia[J]. NeuroRehabilitation, 2015, 36(1): 115-126. doi: 10.3233/NRE-141199
[41]	SHAH-BASAK P P, NORISE C, GARCIA G, et al. Individualized treatment with transcranial direct current stimulation in patients with chronic non-fluent aphasia due to stroke[J]. Front Hum Neurosci, 2015, 9: 201. doi: 10.3389/fpsyg.2018.00201
[42]	SHAH-BASAK P P, SIVARATNAM G, TETI S, et al. High definition transcranial direct current stimulation modulates abnormal neurophysiological activity in post-stroke aphasia[J]. Sci Rep, 2020, 10(1): 19625. doi: 10.1038/s41598-020-76533-0
[43]	SILVA F R D, MAC-KAY A, CHAO J C, et al. Transcranial direct current stimulation: a study on naming performance in aphasic individuals[J]. Codas, 2018, 30(5): e20170242.
[44]	SPIELMANN K, VAN DE SANDT-KOENDERMAN W M E, HEIJENBROK-KAL M H, et al. Transcranial direct current stimulation does not improve language outcome in subacute poststroke aphasia[J]. Stroke, 2018, 49(4): 1018-1020. doi: 10.1161/STROKEAHA.117.020197
[45]	SPIELMANN K, VAN DE SANDT-KOENDERMAN W M, HEIJENBROK-KAL M H, et al. Comparison of two configurations of transcranial direct current stimulation for aphasia treatment[J]. J Rehabil Med, 2018, 50(6): 527-533. doi: 10.2340/16501977-2338
[46]	陶媛媛, 孙蓉, 乐捷, 等. 经颅直流电刺激对卒中后失语患者视听觉通道命名的效果[J]. 中国康复理论与实践, 2019, 25(5): 506-512.
	TAO Y Y, SUN R, LE J, et al. Effects of transcranial direct current stimulation on naming of visual and auditory modality in post-stroke aphasia[J]. Chin J Rehabil Theory Pract, 2019, 25(5): 506-512.
[47]	VILA-NOVA C, LUCENA P H, LUCENA R, et al. Effect of anodal tDCS on articulatory accuracy, word production, and syllable repetition in subjects with aphasia: a crossover, double-blinded, sham-controlled trial[J]. Neurol Ther, 2019, 8(2): 411-424. doi: 10.1007/s40120-019-00149-4
[48]	VOLPATO C, CAVINATO M, PICCIONE F, et al. Transcranial direct current stimulation (tDCS) of Broca's area in chronic aphasia: a controlled outcome study[J]. Behav Brain Res, 2013, 247: 211-216. doi: 10.1016/j.bbr.2013.03.029
[49]	YOU D S, KIM D Y, CHUN M H, et al. Cathodal transcranial direct current stimulation of the right Wernicke's area improves comprehension in subacute stroke patients[J]. Brain Lang, 2011, 119(1): 1-5. doi: 10.1016/j.bandl.2011.05.002
[50]	ZHAO Q, WANG J, LI Z, et al. Effect of anodic transcranial direct current stimulation combined with speech language therapy on nonfluent poststroke aphasia[J]. Neuromodulation, 2021, 24(5): 923-929. doi: 10.1111/ner.13337
[51]	槐雅萍, 左秀芹, 尹昱, 等. 经颅直流电刺激对脑卒中患者失语症恢复的影响[J]. 中国康复理论与实践, 2016, 22(10): 1137-1140.
	HUAI Y P, ZUO X Q, YIN Y, et al. Effects of transcranial direct current stimulation on aphasia after stroke[J]. Chin J Rehabil Theory Pract, 2016, 22(10): 1137-1140.
[52]	方翠霓, 方碧兰, 刘佳, 等. 经颅直流电刺激对脑卒中后语言功能障碍的疗效观察[J]. 中国基层医药, 2017, 24(17): 2603-2606.
	FANG C N, FANG B L, LIU J, et al. Effect of transcranial electrical stimulation on speech dysfunction after stroke[J]. Chin J Primary Med Pharm, 2017, 24(17): 2603-2606.
[53]	张芹, 江钟立, 方欣, 等. 词联导航训练法联合经颅直流电刺激改善失语症言语流畅度及命名能力的临床观察[J]. 中国康复医学杂志, 2017, 32(8): 879-884.
	ZHANG Q, JIANG Z L, FANG X, et al. Effects of word association navigation training with tDCS in patients with chronic non-fluent aphasia[J]. Chin J Rehabil Med, 2017, 32(8): 879-884.
[54]	张洪, 刘静, 杨未风, 等. 经颅直流电刺激联合常规言语康复治疗脑卒中后非流畅性失语症的疗效观察[J]. 康复学报, 2017, 27(3): 39-42, 46.
	ZHANG H, LIU J, YANG W F, et al. Investigation of transcranial direct current stimulation combined with conventional speech rehabilitation therapy to cure non-fluent aphasia after stroke[J]. J Fujian Univ Tradit Chin Med, 2017, 27(3): 39-42, 46.
[55]	汪洁, 吴东宇, 袁英, 等. 前后语言区经颅直流电刺激对失语症图命名作用的比较[J]. 中国康复医学杂志, 2018, 33(8): 910-914.
	WANG J, WU D Y, YUAN Y, et al. A comparison between the effects of transcranial direct current stimulation over anterior and posterior language regions on picture naming in aphasia[J]. Chin J Rehabil Med, 2018, 33(8): 910-914.
[56]	王玲, 张银, 李悦, 等. 非侵入式经颅直流电刺激对脑卒中后失语症的临床效果研究[J]. 四川大学学报(医学版), 2018, 49(5): 815-816.
	WANG L, ZHANG Y, LI Y, et al. J Sichuan Univ (Med Sci Ed), 2018, 49(5): 815-816.
[57]	潘巍一, 葛俊胜, 张捷洪, 等. 经颅直流电刺激对脑卒中后运动性失语疗效及对抑郁状态的影响[J]. 中国康复, 2021, 36(3): 150-153.
	PAN W Y, GE J S, ZHANG J H, et al. Effects of transcranial direct current stimulation on motor aphasia after stroke and depression[J]. Chin J Rehabil, 2021, 36(3): 150-153.
[58]	MARANGOLO P. The potential effects of transcranial direct current stimulation (tDCS) on language functioning: combining neuromodulation and behavioral intervention in aphasia[J]. Neurosci Lett, 2020, 719: 133329. doi: 10.1016/j.neulet.2017.12.057
[59]	BURNS M S, FAHY J. Broca's area: rethinking classical concepts from a neuroscience perspective[J]. Top Stroke Rehabil, 2010, 17(6): 401-410. doi: 10.1310/tsr1706-401
[60]	MARINI A, URGESI C. Please get to the point! A cortical correlate of linguistic informativeness[J]. J Cogn Neurosci, 2012, 24(11): 2211-2222. doi: 10.1162/jocn_a_00283
[61]	SANTOS M D D, CAVENAGHI V B, MAC-KAY A, et al. Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trial[J]. Sao Paulo Med J, 2017, 135(5): 475-480. doi: 10.1590/1516-3180.2016.0194060617
[62]	DARKOW R, MARTIN A, WÜRTZ A, et al. Transcranial direct current stimulation effects on neural processing in post-stroke aphasia[J]. Hum Brain Mapp, 2017, 38(3): 1518-1531. doi: 10.1002/hbm.23469
[63]	TURKELTAUB P E, SWEARS M K, D'MELLO A M, et al. Cerebellar tDCS as a novel treatment for aphasia? Evidence from behavioral and resting-state functional connectivity data in healthy adults[J]. Restor Neurol Neurosci, 2016, 34(4): 491-505.
[64]	NAESER M A, MARTIN P I, BAKER E H, et al. Overt propositional speech in chronic nonfluent aphasia studied with the dynamic susceptibility contrast fMRI method[J]. Neuroimage, 2004, 22(1): 29-41. doi: 10.1016/j.neuroimage.2003.11.016
[65]	KINSBOURNE M. A model for the mechanism of unilateral neglect of space[J]. Trans Am Neurol Assoc, 1970, 95: 143-146.
[66]	BLANK S C, BIRD H, TURKHEIMER F, et al. Speech production after stroke: the role of the right pars opercularis[J]. Ann Neurol, 2003, 54(3): 310-320. doi: 10.1002/ana.10656
[67]	CROSSON B, MOORE A B, MCGREGOR K M, et al. Regional changes in word-production laterality after a naming treatment designed to produce a rightward shift in frontal activity[J]. Brain Lang, 2009, 111(2): 73-85. doi: 10.1016/j.bandl.2009.08.001

研究	1	2	3	4	5	总偏倚	研究	1	2	3	4	5	总偏倚
Branscheidt等^[16](2018)	+	+	+	+	±	±	Pestalozzi等^[36](2018)	±	+	+	+	+	±
Campana等^[13](2015)	±	±	+	+	+	±	Pisano等^[37](2021)	±	+	+	+	+	±
Cherney等^[17](2021)	+	+	+	+	+	+	Polanowska等^[38](2013)a	±	+	+	+	+	±
Cipollari等^[18](2015)	±	±	+	+	+	±	Polanowska等^[39](2013)b	±	+	+	+	+	±
Darkow等^[9](2017)	±	+	+	+	+	±	Richardson等^[40](2015)	±	+	+	+	+	±
Feil等^[19](2019)	+	+	+	+	+	+	Shah-Basak等^[41](2015)	±	±	±	+	+	±
Fiori等^[20](2013)	±	+	+	+	+	±	Shah-Basak等^[42](2020)	±	+	+	+	+	±
Fiori等^[21](2019)	+	+	+	+	+	+	Silva等^[43](2018)	±	±	+	+	+	±
Flöel等^[22](2011)	±	+	+	+	+	±	Spielmann等^[44](2018)a	±	+	+	+	+	±
Fridriksson等^[23](2018)	+	+	+	+	+	+	Spielmann等^[45](2018)b	±	+	+	+	+	±
Guillouët等^[24](2020)	±	+	+	+	+	±	Vila-Nova等^[47](2019)	±	+	+	+	+	±
Ihara等^[25](2020)	±	+	+	+	±	±	Volpato等^[48](2013)	-	±	+	+	+	-
Kang等^[26](2011)	+	+	+	+	+	+	You等^[49](2011)	±	+	+	+	+	±
Keser等^[27](2017)	±	+	+	+	+	±	Zhao等^[50](2021)	+	+	+	+	+	+
Kurfeß等^[28](2020)	±	+	+	+	+	±	陶媛媛等^[46](2019)	±	±	+	+	+	±
Marangolo等^[29](2013)a	±	+	+	+	+	±	魏雅萍等^[51](2016)	+	+	+	+	±	+
Marangolo等^[30](2013)b	+	+	+	+	+	+	方翠霓等^[52](2017)	+	+	+	+	±	+
Marangolo等^[31](2014)	±	+	+	+	+	±	张芹等^[53](2017)	±	±	+	±	+	±
Marangolo等^[11](2016)	±	+	+	+	+	±	张洪等^[54](2017)	+	+	+	+	±	+
Marangolo等^[32](2018)	±	±	+	±	+	±	汪洁等^[55](2018)	+	+	+	±	±	±
Meinzer等^[33](2016)	±	+	+	+	+	±	王玲等^[56](2018)	+	+	+	+	±	+
Monti等^[34](2008)	±	+	+	+	+	±	潘巍一等^[57](2021)	±	+	+	+	±	+
Norise等^[35](2017)	±	±	+	+	+	±

经颅直流电刺激改善卒中后失语的系统综述

Effects transcranial direct current stimulation on post-stroke aphasia: a systematic review

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 4

参考文献 67

相关文章 15

Metrics

本文评价

推荐阅读 0

[1]	周治宁, 周容, 肖燕文, 王博文, 吕娇娇, 刘宇. 多靶区经颅直流电刺激对健康成年人工作记忆-姿势控制双任务表现的影响[J]. 《中国康复理论与实践》, 2024, 30(1): 21-28.
[2]	王航宇, 葛可可, 范永红, 都丽露, 邹敏, 封磊. 基于ICD-11和ICF主动式音乐疗法改善认知障碍老年人认知功能的系统综述[J]. 《中国康复理论与实践》, 2024, 30(1): 36-43.
[3]	闻嘉宁, 金秋艳, 张琦, 李杰, 司琦. 认知参与型身体活动对发展儿童青少年执行功能的效果：基于ICF的系统综述[J]. 《中国康复理论与实践》, 2024, 30(1): 44-53.
[4]	葛可可, 范永红, 王航宇, 都丽露, 李长江, 邹敏. 失眠老年人正念干预健康效益的系统综述[J]. 《中国康复理论与实践》, 2024, 30(1): 54-60.
[5]	林娜, 高菡璐, 卢惠苹, 陈燕清, 郑军凡, 陈述荣. 虚拟现实技术对脑卒中上肢功能影响的弥散张量成像研究[J]. 《中国康复理论与实践》, 2024, 30(1): 61-67.
[6]	王昊懿, 史亚伟, 鲁俊, 许光旭. 主观垂直感知障碍对脑卒中患者功能影响的回顾性研究[J]. 《中国康复理论与实践》, 2024, 30(1): 68-73.
[7]	陈珺雯, 陈谦, 陈程, 李淑月, 刘玲玲, 吴存书, 龚翔, 鲁俊, 许光旭. 改良八段锦身体活动对脑卒中患者心肺功能、运动功能和日常生活活动能力的效果[J]. 《中国康复理论与实践》, 2024, 30(1): 74-80.
[8]	胡永林, 马颖, 窦超, 陆安民, 江小鸽, 宋新建, 肖玉华. 肩部控制训练联合神经松动术对脑卒中偏瘫患者肩痛及上肢功能的效果[J]. 《中国康复理论与实践》, 2024, 30(1): 81-86.
[9]	张婧雅, 邹敏, 孙宏伟, 孙昌隆, 朱峻同. 听障儿童青少年焦虑或抑郁情绪心理干预效果的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1004-1011.
[10]	王俊宇, 杨永, 袁逊, 谢婷, 庄洁. 高强度间歇训练对健康儿童青少年执行功能效果的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1012-1020.
[11]	魏晓微, 杨剑, 魏春艳. 特殊教育学校孤独症谱系障碍儿童参与适应性瑜伽活动的心理与行为效益的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1021-1028.
[12]	杨亚茹, 杨剑. 基于WHO-HPS架构学校身体活动相关健康服务及其健康效益：系统综述的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1040-1047.
[13]	王贺, 韩靓, 阚梦凡, 于少泓. 电刺激治疗脑卒中后肩手综合征有效性的系统评价与Meta分析[J]. 《中国康复理论与实践》, 2023, 29(9): 1048-1056.
[14]	史佳伟, 李凌宇, 杨浩杰, 王琴潞, 邹海欧. 预康复对全膝关节置换术后患者的有效性：系统综述的系统综述[J]. 《中国康复理论与实践》, 2023, 29(9): 1057-1064.
[15]	孙藤方, 任梦婷, 杨琳, 王耀霆, 王红雨, 闫兴洲. 高压氧治疗联合重复外周磁刺激干预脑卒中患者踝运动功能和平衡能力的效果[J]. 《中国康复理论与实践》, 2023, 29(8): 875-881.