新型可穿戴式经皮胫神经刺激器抑制猫膀胱反射的刺激参数研究

doi:10.3969/j.issn.1006-9771.2022.07.009

《中国康复理论与实践》 ›› 2022, Vol. 28 ›› Issue (7): 797-802.doi: 10.3969/j.issn.1006-9771.2022.07.009

新型可穿戴式经皮胫神经刺激器抑制猫膀胱反射的刺激参数研究

梁雅楠^1,^2a,何盼奇^1,^2a,廖利民^1,^2,a^2,b³()

1.首都医科大学康复医学院,北京市 100068
2.中国康复研究中心北京博爱医院,a. 泌尿外科;b. 神经泌尿科,北京市 100068
3.首都医科大学泌尿外科学系,北京市 100069

收稿日期:2021-12-01 修回日期:2022-02-07 出版日期:2022-07-25 发布日期:2022-08-08
通讯作者: 廖利民 E-mail:lmliao@263.net
作者简介:梁雅楠(1995-),女,汉族,安徽宿州市人,硕士研究生,医师,主要研究方向：神经泌尿与尿动力学。|廖利民(1964-),男,汉族,四川高县人,博士,教授、主任医师,博士生导师,主要研究方向：神经泌尿学与尿动力学。
基金资助:
中国康复研究中心青年基金项目(2020-Q9);国家重点研发项目(2018YFC2002203)

A novel wearable transcutaneous tibial nerve stimulator inhibits bladder reflexes in cats

LIANG Yanan^1,^2a,HE Panqi^1,^2a,LIAO Limin^1,^2,a^2,b³()

1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
2. a. Department of Urology; b. Department of Neurourology, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
3. Department of Urology, Capital Medical University, Beijing 100068, China

Received:2021-12-01 Revised:2022-02-07 Published:2022-07-25 Online:2022-08-08
Contact: LIAO Limin E-mail:lmliao@263.net
Supported by:
China Rehabilitation Research Center Young Fund(2020-Q9);National Key Research and Development Project(2018YFC2002203)

摘要/Abstract

摘要：

目的探究一种新型智能型可穿戴式经皮胫神经刺激器在不同刺激参数下对猫生理性膀胱反射的抑制作用。

方法 18只猫分为强度组、频率组和波形组,将胫神经刺激器穿戴在猫的内踝处,分别采用不同阈值(T)强度(1/2 T、1 T、3/2 T、2 T)、刺激频率(5 Hz、10 Hz、15 Hz、30 Hz)和波形(波形A、波形B)行胫神经刺激(TNS)。麻醉后,向猫的膀胱缓慢灌注生理盐水,诱发膀胱反射,同时进行膀胱压力容积测定。比较各组膀胱测压图。

结果不同强度刺激后,膀胱容量无显著性差异(F = 1.997, P = 0.126),其中3/2 T和2 T刺激时,膀胱容量高于基础膀胱容量(P < 0.05)。不同频率刺激后,膀胱容量有显著性差异(F = 3.894, P = 0.014),5 Hz、10 Hz和15 Hz刺激后,膀胱容量高于基础膀胱容量(P < 0.05)。不同波形刺激后,膀胱容量有显著性差异(F = 5.184, P = 0.019),波形A刺激后,膀胱容量高于基础膀胱容量(P < 0.05)。

结论新型智能型可穿戴式经皮胫神经刺激器能有效抑制猫生理膀胱反射,抑制效果与刺激强度、频率和波形有关。

关键词: 胫神经刺激, 膀胱过度活动症, 频率, 强度, 波形, 猫

Abstract:

Objective To observe the inhibitory effects of a novel wearable transcutaneous tibial nerve stimulator on bladder reflex in cats under different stimulation parameters.

Methods A total of 18 cats were divided into intensities, frequencies and waveforms groups, which wore the stimulator on the ankles and stimulated in different threshold (T) intensities (1/2 T, 1 T, 3/2 T and 2 T), frequencies (5 Hz, 10 Hz, 15 Hz and 30 Hz) and waveforms (A and B). The cats were anesthetized and infused normal saline to induce bladder reflex, while the bladder capacity was measured. Cystometrograms were compared among stimulation parameters.

Results The bladder capacity was not significantly different among the intensities (F = 1.997, P = 0.126), while the bladder capacity was more after TNS of 3/2 T and 2 T than baseline (P < 0.05). The bladder capacity was significantly different among the frequencies (F = 3.894, P = 0.014), while the bladder capacity was more after 5 Hz, 10 Hz and 15 Hz of TNS (P < 0.05). The bladder capacity was significantly different between the waveforms (F = 5.184, P = 0.019), while the bladder capacity was more after waveform A of TNS than baseline (P < 0.05).

Conclusion The novel wearable transcutaneous tibial nerve stimulator can effectively inhibit the physiological bladder reflex in cats, which associates to the intensity, frequency and waveform of stimulation.

Key words: tibial nerve stimulation, overactive bladder, frequency, intensity, waveform, cats

中图分类号:

R694

梁雅楠,何盼奇,廖利民. 新型可穿戴式经皮胫神经刺激器抑制猫膀胱反射的刺激参数研究[J]. 《中国康复理论与实践》, 2022, 28(7): 797-802.

LIANG Yanan,HE Panqi,LIAO Limin. A novel wearable transcutaneous tibial nerve stimulator inhibits bladder reflexes in cats[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2022, 28(7): 797-802.

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参考文献 28

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新型可穿戴式经皮胫神经刺激器抑制猫膀胱反射的刺激参数研究

A novel wearable transcutaneous tibial nerve stimulator inhibits bladder reflexes in cats

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强度	n	标准化膀胱容量
基础膀胱容量	6	99.85±5.27
1/2 T	6	105.79±19.51
1 T	6	110.69±20.59
3/2 T	6	148.04±12.16^a
2 T	6	138.78±7.38^a
F值		1.997
P值		0.126

强度	n	标准化膀胱容量
基础膀胱容量	6	98.56±3.73
5 Hz	6	140.43±12.78^a
10 Hz	6	150.06±18.54^a
15 Hz	6	145.93±11.34^a
30 Hz	6	116.02±5.18
F值		3.894
P值		0.014

强度	n	标准化膀胱容量
基础膀胱容量	6	97.35±1.31
波形A	6	166.18±15.17^a
波形B	6	127.64±13.00
F值		5.184
P值		0.019

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