老年人平衡功能的脑网络变化：基于功能性近红外线光谱研究

doi:10.3969/j.issn.1006-9771.2023.02.013

《中国康复理论与实践》 ›› 2023, Vol. 29 ›› Issue (2): 238-242.doi: 10.3969/j.issn.1006-9771.2023.02.013

老年人平衡功能的脑网络变化：基于功能性近红外线光谱研究

罗启航¹^,²^,³, 吴羽皙¹^,²^,³, 张嘉璇², 黎婉颖¹^,²^,³, 欧海宁¹^,²^,³, 林强¹^,²^,³, 梁俊杰¹^,²^,³()

1.广州医科大学附属第五医院康复医学科，广东高校生物靶向诊治与康复重点实验室，广东广州市 510700
2.广州医科大学，广东广州市 511436
3.广州医科大学康复实验室，广东广州市 510700

收稿日期:2022-05-24 修回日期:2023-01-10 出版日期:2023-02-25 发布日期:2023-03-16
通讯作者: 梁俊杰 E-mail:ljj88961@gzhmu.edu.cn
作者简介:罗启航(2000-)，男，汉族，四川南充市人，本科生。
基金资助:
广州市卫生健康科技项目(20211A011105);广州市卫生健康科技项目(20211A011106);广东省普通高校青年创新人才类项目(2019KQNCX119);广东省医学科研基金项目(B2021007);广州市基础研究计划市校(院)联合资助基础项目(202102010100);广州市医学重点学科项目(2021-2023);The Key Medical Discipline of Guangzhou(2021-2023);广东高校生物靶向诊治与康复重点实验室项目(2021KSYS009)

Brain network during balance in older adults: a functional near-infrared spectroscopy study

LUO Qihang¹^,²^,³, WU Yuxi¹^,²^,³, ZHANG Jiaxuan², LI Wanying¹^,²^,³, OU Haining¹^,²^,³, LIN Qiang¹^,²^,³, LIANG Junjie¹^,²^,³()

1. Department of Rehabilitation, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, China
2. Guangzhou Medical University, Guangzhou, Guangdong 511436, China
3. Rehabilitation Laboratory of Guangzhou Medical University, Guangzhou, Guangdong 510700, China

Received:2022-05-24 Revised:2023-01-10 Published:2023-02-25 Online:2023-03-16
Contact: LIANG Junjie E-mail:ljj88961@gzhmu.edu.cn
Supported by:
Guangzhou Health and Family Planning Commission General Guidance Project(20211A011105);Guangzhou Health and Family Planning Commission General Guidance Project(20211A011106);Young Innovative Talents Project for Colleges and Universities in Guangdong(2019KQNCX119);Guangdong Medical Research Fund(B2021007);Guangzhou Basic Research Program (Funding of City and University)(202102010100);Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes(2021KSYS009)

摘要/Abstract

摘要：

目的探究老年人完成平衡控制任务的脑网络特征。方法 2022年1月至4月，于广州医科大学附属第五医院和社区招募22例健康年轻人和20例健康老年人，两组站在足底压力测试板上，完成睁眼或闭眼站立任务，功能性近红外光谱测量左、右前额叶皮质(PFC)和初级运动区(PMC)功能连接强度。结果老年人闭眼状态下的椭圆面积(Z = -2.884, P < 0.01)和最大摆动范围(Z = -2.481, P < 0.05)大于年轻人；站立任务时，老年人左侧(t = 2.978, P < 0.01)和右侧PFC(Z = -3.123, P < 0.01)内部功能连接降低；右PMC-左PFC (t = 2.087, P < 0.05)和右PFC-左PFC (t = 3.471, P < 0.001)间功能连接降低。结论与年轻人相比，老年人在平衡控制任务中出现PFC功能连接降低，可能与早期脑老化有关。

关键词: 老年人, 脑老化, 平衡控制, 功能性近红外线光谱, 功能连接, 前额叶

Abstract:

Objective To study the brain network during balance control tasks in older adults. Methods From January to April, 2022, 22 healthy young adults and 20 healthy older adults were recruited from the Fifth Affiliated Hospital of Guangzhou Medical University and communities. They were asked to finish standing tasks on the plantar pressure plate with eyes opening and closing, while the functional connectivities (FC) of prefrontal cortex (PFC) and primary motor cortex (PMC) were measured with functional near-infrared spectroscopy. Results Compared with the young adults, the area of the ellipse (Z = -2.884, P < 0.01) and the maximum swing (Z = -2.481, P < 0.05) increased in the older adults as eyes closing. During the standing task, the intra-FC of left (t = 2.978, P < 0.01) and right (Z = -3.123, P < 0.01) PFC decreased in the older adults, and the inter-FC of right PMC to left PFC (t = 2.087, P < 0.05) and right PFC to left PFC (t = 3.471, P < 0.001) decreased, too. Conclusion The FC of PFC decreased in healthy older adults during balance control tasks, which may be a indicator for aging brain.

Key words: older adults, aging brain, balance control, functional near-infrared spectroscopy, functional connectivity, prefrontal cortex

中图分类号:

R743.3

罗启航, 吴羽皙, 张嘉璇, 黎婉颖, 欧海宁, 林强, 梁俊杰. 老年人平衡功能的脑网络变化：基于功能性近红外线光谱研究[J]. 《中国康复理论与实践》, 2023, 29(2): 238-242.

LUO Qihang, WU Yuxi, ZHANG Jiaxuan, LI Wanying, OU Haining, LIN Qiang, LIANG Junjie. Brain network during balance in older adults: a functional near-infrared spectroscopy study[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(2): 238-242.

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参考文献 26

[1]	YANKNER B A, LU T, LOERCH P. The aging brain[J]. Annu Rev Pathol, 2008, 3: 41-66. doi: 10.1146/pathmechdis.2008.3.issue-1
[2]	保莎莎, 朱钰, 杨露, 等. 多模态MRI技术评估脑老化及脑老化与脑疾病的关系研究进展[J]. 中国介入影像与治疗学, 2022, 19(2): 115-118.
	BAO S S, ZHU Y, YANG L, et al. Research advances of multimodal MRI in evaluation on brain aging and the relationship of brain aging and brain diseases[J]. Chin J Interven Imag Ther, 2022, 19(2): 115-118.
[3]	RANA M, VARAN A Q, DAVOUDI A, et al. Real-time fMRI in neuroscience research and its use in studying the aging brain[J]. Front Aging Neurosci, 2016, 8: 239. pmid: 27803662
[4]	鲁朝玉, 谢军, 余其贵. 人体平衡能力检测与衰弱指数在老年患者跌倒风险评估中的应用[J]. 当代临床医刊, 2022, 35(2): 23-24.
	LU C Y, XIE J, YU Q G. Application of human balance ability test and frailty index in fall risk assessment for elders[J]. Med J Present Clin, 2022, 35(2): 23-24.
[5]	DŁUGOSZ-BOŚ M, FILAR-MIERZWA K, STAWARZ R, et al. Effect of three months pilates training on balance and fall risk in older women[J]. Int J Environ Res Public Health, 2021, 18(7): 3663. doi: 10.3390/ijerph18073663
[6]	LARIVIÈRE S, XIFRA-PORXAS A, KASSINOPOULOS M, et al. Functional and effective reorganization of the aging brain during unimanual and bimanual hand movements[J]. Hum Brain Mapp, 2019, 40(10): 3027-3040. doi: 10.1002/hbm.24578 pmid: 30866155
[7]	SUTKOWY P, WOŹNIAK A, MILA-KIERZENKOWSKA C, et al. Physical activity vs. redox balance in the brain: brain health, aging and diseases[J]. Antioxidants (Basel, Switzerland), 2021, 11(1): 95.
[8]	SURGENT O J, DADALKO O I, PICKETT K A, et al. Balance and the brain: a review of structural brain correlates of postural balance and balance training in humans[J]. Gait Posture, 2019, 71(2): 45-52.
[9]	范晨雨, 李浩正, 谢鸿宇, 等. 基于功能性近红外光谱技术的健康青年人、老年人皮层脑网络静息态功能连接的特征研究[J]. 中国康复医学杂志, 2021, 36(8): 931-937, 942.
	FAN C Y, LI H Z, XIE H Y, et al. Healthy young and old adults functional connectivity among cortical networks: a resting-state functional near-infrared spectroscopy study[J]. Chin J Rehabil Med, 2021, 36(8): 931-937, 942.
[10]	CHEN W L, WAGNER J, HEUGEL N, et al. Functional near-infrared spectroscopy and its clinical application in the field of neuroscience: advances and future directions[J]. Front Neurosci, 2020, 14(7): 24. doi: 10.3389/fnins.2020.00024
[11]	PELICIONI P H S, LORD S R, STURNIEKS D L, et al. Cognitive and motor cortical activity during cognitively demanding stepping tasks in older people at low and high risk of falling[J]. Front Med (Lausanne), 2021, 8(5): 54231.
[12]	DANS P W, FOGLIA S D, NELSON A J. Data processing in functional near-infrared spectroscopy (fNIRS) motor control research[J]. Brain Sci, 2021, 11(5): 606. doi: 10.3390/brainsci11050606
[13]	ZHAO W, HUI M, ZHANG X, et al. The relationship between motor coordination and imitation: an fNIRS study[J]. Brain Sci, 2021, 11(8): 1052. doi: 10.3390/brainsci11081052
[14]	QIU Y, ZHENG Y, LIU Y, et al. Synergistic immediate cortical activation on mirror visual feedback combined with a soft robotic bilateral hand rehabilitation system: a functional near infrared spectroscopy study[J]. Front Neurosci, 2022, 16(8): 07045.
[15]	ST GEORGE R J, HINDER M R, PURI R, et al. Functional near-infrared spectroscopy reveals the compensatory potential of pre-frontal cortical activity for standing balance in young and older adults[J]. Neuroscience, 2021, 452(2): 8-18.
[16]	林强, 郑煜欣, 廖婉晨, 等. 脑卒中患者静态平衡的足底压力分析[J]. 中国康复理论与实践, 2021, 27(3): 290-296.
	LIN Q, ZHENG Y X, LIAO W C, et al. Static balance function in stroke patients: a plantar pressure analysis[J]. Chin J Rehabil Theory Pract, 2021, 27(3): 290-296.
[17]	ZHANG N, YUAN X, LI Q, et al. The effects of age on brain cortical activation and functional connectivity during video game-based finger-to-thumb opposition movement: a functional near-infrared spectroscopy study[J]. Neurosci Lett, 2021, 746: 135668. doi: 10.1016/j.neulet.2021.135668
[18]	BLINKOUSKAYA Y, CAÇOILO A, GOLLAMUDI T, et al. Brain aging mechanisms with mechanical manifestations[J]. Mech Age Dev, 2021, 200: 111575. doi: 10.1016/j.mad.2021.111575
[19]	AMBROSE A F, PAUL G, HAUSDORFF J M. Risk factors for falls among older adults: a review of the literature[J]. Maturitas, 2013, 75(1): 51-61. doi: 10.1016/j.maturitas.2013.02.009 pmid: 23523272
[20]	ARON L, ZULLO J, YANKNER B A. The adaptive aging brain[J]. Curr Opin Neurobiol, 2022, 72(5): 91-100. doi: 10.1016/j.conb.2021.09.009
[21]	TABARA Y, OKADA Y, OHARA M, et al. Association of postural instability with asymptomatic cerebrovascular damage and cognitive decline: the Japan Shimanami health promoting program study[J]. Stroke, 2015, 46(1): 16-22. doi: 10.1161/STROKEAHA.114.006704 pmid: 25523051
[22]	SEIDEL O, CARIUS D, KENVILLE R, et al. Motor learning in a complex balance task and associated neuroplasticity: a comparison between endurance athletes and nonathletes[J]. J Neurophysiol, 2017, 118(3): 1849-1860. doi: 10.1152/jn.00419.2017 pmid: 28659467
[23]	SURGENT O J, DADALKO O I, PICKETT K A, et al. Balance and the brain: a review of structural brain correlates of postural balance and balance training in humans[J]. Gait Posture, 2019, 71(2): 45-52.
[24]	TEO W P, GOODWILL A M, HENDY A M, et al. Sensory manipulation results in increased dorsolateral prefrontal cortex activation during static postural balance in sedentary older adults: an fNIRS study[J]. Brain Behav, 2018, 8(10): e01109. doi: 10.1002/brb3.2018.8.issue-10
[25]	FUJITA H, KASUBUCHI K, WAKATA S, et al. Role of the frontal cortex in standing postural sway tasks while dual-tasking: a functional near-infrared spectroscopy study examining working memory capacity[J]. Biomed Res Int, 2016, 2016: 7053867.
[26]	LEHMANN N, KUHN Y A, KELLER M, et al. Brain activation during active balancing and its behavioral relevance in younger and older adults: a functional near-infrared spectroscopy (fNIRS) study[J]. Front Aging Neurosci, 2022, 14(8): 28474.

平衡参数	状态	年轻人(n = 22)	老年人(n = 20)	t值/Z值	P值
球长度/mm	睁眼	203.037±40.888	211.073±64.185	-0.489	0.628
球长度/mm	闭眼	228.127±62.178	234.149±50.550	-0.342	0.732
椭圆面积/cm²	睁眼	22.968±21.178	31.475±20.742	-1.436^a	0.151
椭圆面积/cm²	闭眼	35.489±26.258	96.252±90.073	-2.884^a	0.004
平均速度/(mm·s^-1)	睁眼	10.219±2.044	10.634±3.230	-0.503	0.618
平均速度/(mm·s^-1)	闭眼	11.382±3.124	11.678±2.535	-0.334	0.740
平均X/mm	睁眼	1.247±8.435	1.968±9.546	-0.260	0.796
平均X/mm	闭眼	0.041±7.982	3.255±8.292	-0.504^a	0.614
平均Y/mm	睁眼	-21.258±10.856	-25.837±11.179	1.346	0.186
平均Y/mm	闭眼	-21.583±11.161	-27.516±10.339	1.782	0.082
椭圆倾斜角/°	睁眼	86.091±42.808	85.850±48.930	-0.101^a	0.920
椭圆倾斜角/°	闭眼	86.455±46.030	96.400±42.057	-0.667^a	0.504
椭圆偏心角/°	睁眼	0.514±0.244	0.398±0.276	-1.537^a	0.124
椭圆偏心角/°	闭眼	0.458±0.222	0.471±0.307	-0.156	0.879
最大摆动/mm	睁眼	1.461±0.413	1.574±0.578	-0.735	0.467
最大摆动/mm	闭眼	2.588±3.989	2.646±1.379	-2.481^a	0.013
最小摆动/mm	睁眼	0.013±0.010	0.013±0.010	-0.054^a	0.957
最小摆动/mm	闭眼	0.012±0.010	0.016±0.007	-1.467^a	0.142

ROI	年轻人 (n = 22)	老年人 (n = 20)	t值/Z值	P值
LPMC	0.706±0.222	0.691±0.199	-0.529^a	0.597
LPFC	0.747±0.118	0.562±0.264	2.978	0.005
RPMC	0.653±0.189	0.641±0.177	0.220	0.827
RPFC	0.737±0.118	0.545±0.205	-3.123^a	0.002
LPMC-RPMC	0.643±0.190	0.594±0.194	0.821	0.416
LPMC-RPFC	0.539±0.183	0.441±0.220	1.564	0.126
LPMC-LPFC	0.529±0.182	0.481±0.205	0.811	0.422
RPMC-RPFC	0.538±0.168	0.431±0.185	1.968	0.056
RPMC-LPFC	0.534±0.168	0.415±0.202	2.087	0.043
RPFC-LPFC	0.677±0.128	0.473±0.240	3.471	< 0.001

老年人平衡功能的脑网络变化：基于功能性近红外线光谱研究

Brain network during balance in older adults: a functional near-infrared spectroscopy study

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