重复经颅磁刺激治疗脑卒中后下肢运动功能障碍的Scoping综述

doi:10.3969/j.issn.1006-9771.2023.03.007

《中国康复理论与实践》 ›› 2023, Vol. 29 ›› Issue (3): 286-293.doi: 10.3969/j.issn.1006-9771.2023.03.007

• 专题非侵入式神经调控技术在康复中的应用 • 上一篇下一篇

重复经颅磁刺激治疗脑卒中后下肢运动功能障碍的Scoping综述

黄凯琪^1a, 辛榕^1a, 凌耿强^1b, 王朴^1a()

1.中山大学附属第七医院， a.康复医学科；b. 神经医学中心，广东深圳市 518107

收稿日期:2022-10-10 修回日期:2022-12-23 出版日期:2023-03-25 发布日期:2023-04-14
通讯作者: 王朴 E-mail:wangpu@sysush.com
作者简介:黄凯琪(1991-)，女，汉族，江西赣州市人，医师，主要从事老年病康复。
基金资助:
1.国家重点研发计划项目(2020YFC2004302);2.国家自然科学基金项目(U21A20479);3.深圳市科技研发项目(JCYJ20190809151007769)

Repetitive transcranial magnetic stimulation for lower limb dysfunction post stroke: a scoping review

HUANG Kaiqi^1a, XIN Rong^1a, LING Gengqiang^1b, WANG Pu^1a()

1. a. Department of Rehabilitation Medicine; b. Brain Center, the Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518107, China

Received:2022-10-10 Revised:2022-12-23 Published:2023-03-25 Online:2023-04-14
Contact: WANG Pu E-mail:wangpu@sysush.com
Supported by:
National Key R&D Program of China(2020YFC2004302);National Natural Science Foundation of China(U21A20479);Shenzhen Science and Technology Program(JCYJ20190809151007769)

摘要/Abstract

摘要：

目的总结分析重复经颅磁刺激(rTMS)治疗脑卒中后下肢运动功能障碍的刺激方案。

方法检索建库至2022年8月17日Web of Science、PubMed、中国知网、万方数据库中rTMS治疗脑卒中后下肢运动功能障碍的相关文献。采用物理治疗证据数据库(PEDro)量表对纳入文献进行质量评价。由两名研究人员筛选文献、整理资料并进行Scoping综述。

结果最终纳入文献21篇，20项研究结果显示rTMS治疗有益于脑卒中后下肢运动功能障碍的恢复，1项研究结果为阴性。所有研究结果均提示rTMS治疗安全性良好，无严重不良反应。纳入研究中受试者情况、研究设计方案、刺激疗程、线圈类型及刺激部位、运动诱发电位的测定等均存在异质性。

结论 rTMS治疗脑卒中后下肢运动功能障碍的研究需要结合脑卒中的病程和损伤的程度来制定刺激方案。同时，需要更多同类型设计及刺激方案信息完整的真刺激对照假刺激的rTMS研究来提高其应用的证据水平。

关键词: 脑卒中, 重复经颅磁刺激, 下肢, 运动功能, Scoping综述

Abstract:

Objective To summarize and analyze the protocols of repetitive transcranial magnetic stimulation (rTMS) in the treatment of post-stroke lower limb dysfunction.

Methods Literature about rTMS for lower limb dysfunction of patients post stroke were retrieved from Web of Science, PubMed, CNKI, and Wanfang Data from inception to August 17, 2022. The quality of the literature was evaluated with Physiotherapy Evidence Database (PEDro) scale. Literature quality, data extraction and scoping review were performed by two researchers.

Results A total of 21 studies were included, in which 20 studies suggested that rTMS treatment could promote the recovery of lower limb motor function after stroke. One study showed negative result. rTMS interventions were reported safe, with no serious adverse reactions. There were great heterogeneity in the demographic and clinical information, study protocols, stimulation parameters, coil types, targets of stimulation, and motor-evoked potential measurement in the included studies.

Conclusion The future protocols of rTMS need to be combined with stroke stage and severity of injury. There is a demand for more real vs. sham rTMS studies, reporting similar designs with sufficient information, to achieve a significant level of evidence regarding the use of rTMS in post-stroke patients.

Key words: stroke, repetitive transcranial magnetic stimulation, lower limb, motor function, scoping review

中图分类号:

R743.3

黄凯琪, 辛榕, 凌耿强, 王朴. 重复经颅磁刺激治疗脑卒中后下肢运动功能障碍的Scoping综述[J]. 《中国康复理论与实践》, 2023, 29(3): 286-293.

HUANG Kaiqi, XIN Rong, LING Gengqiang, WANG Pu. Repetitive transcranial magnetic stimulation for lower limb dysfunction post stroke: a scoping review[J]. 《Chinese Journal of Rehabilitation Theory and Practice》, 2023, 29(3): 286-293.

图/表 4

图1

表1

表2

高频rTMS治疗结果分析"

纳入研究	性质(梗死/出血)/n	年龄/岁	病程	研究设计	部位	方案	频率/Hz	线圈	强度 /RMT	观察指标	主要结果
Kakuda等^[16](2013)	6/12	30~70	> 12个月	单组试验	双侧下肢皮质运动区	每次20 min，每天2次，共13 d	10	双锥形	90%	10MWT，PCI	改善下肢步行功能
杨露等^[17](2016)	17/11	56.4±7.8	> 6个月	RCT	M1区	每次20 min，每天1次，每周6 d，共4周	10	“8”字形	90%	FMA-LE，步态分析系统测试	改善下肢运动功能
Cha等^[18](2017)	19/11	40~60	< 6 个月	RCT	M1区	每次10 min，每天1次，每周5 d，共8周	10	“8”字形	90%	MEP，等速测力仪测量踝关节肌肉力量，10MWT	肌力改善、步行速度提高
Chieffo等^[19](2021)	7/5	25~80	≥ 6个月	交叉实验	双侧下肢皮质运动区	每次15 min，共3周，第1周5次，第2周3次，第3周3次	20	H形	90%	FMA-LE，MAS，10MWT，6MWT	改善运动功能和痉挛
Ji等^[20](2016)	21/9	40~60	< 3个月	RCT	M1区	每次15 min，每天1次，每周5 d，共4周	10	“8”字形	80%	动态平衡仪，静态平衡仪	改善静态平衡和动态平衡功能
Chieffo等^[21](2014)	5/5	49~74	> 6个月	交叉研究	双侧下肢皮质运动区	每次30 min，第1周5次，第2周3次，第3周3次，共3周	20	H形	90%	FMA-LE，10MWT，6MWT	FMA-LE评分改善，步行速度无明显改变
杨阳等^[22](2015)	73/47	58.7±3.5	(4.6±1.2) d	RCT	M1区	每次15 min，每天1次，每周5 d，共8周	2	“8”字形	90%	FMA-LE，10MWT，CSI，FAC	改善肢体运动功能
Sasaki等^[23](2017)	11/10	61.4±13.7	(10.9±6.6) d	RCT	双侧下肢皮质运动区	每次10 min，每天2次，共5 d	10	双锥形	90%	Brunnstrom分期，ABMSII	改善下肢运动功能
Choi等^[24](2016)	20/10	60~85	6~10个月	交叉研究	患侧躯干运动皮质区	每次10 min，每天1次，每周5 d，共2周	10	“8”字形	90%	BBS，动态平衡评估	改善平衡功能
Wang等^[25](2019)	6/8	53.5 ± 13.7	> 6个月	RCT	患侧下肢皮质运动区	每次15 min，每天1次，每周3 d，共3周	5	“8”字形	90%	步态分析，MEP，肌电图，FMA-LE	改善下肢运动功能、下肢肌肉激活程度
Kakuda等^[26](2013)	5/13	30~70	> 12个月	交叉研究	双侧下肢皮质运动区	每次20 min，共1次	10	双锥形	90%	10MWT，PCI	改善下肢步行功能
Goh等^[27](2020)	14/1	43~76	(22.8±16.7)个月	重复测量	患侧DLPFC	每次5 min，共1次	5	“8”字形	90%	测量单任务和双任务步行速度	双任务步行速度改善

表2

表3

低频rTMS治疗结果分析"

纳入研究		年龄/岁	病程	研究设计	部位	方案	频率/Hz	线圈	强度 /RMT	观察指标	主要结果
Rastgoo等^[28](2016)	15/5	> 18	(30.2±18.3)个月	交叉试验	健侧下肢皮质运动区	每次20 min, 每天1次，每周5 d，共4周	1	“8”字形	90%	MAS，FMA-LE，H反射，TUGT	下肢痉挛改善，运动功能改善
李亚梅等^[29](2016)	60/0	18~75	> 3个月	RCT	健侧M1区	每次20 min, 每天1次，每周5 d，共4周	1	“8”字形	90%	FMA-LE，10MWS	偏瘫下肢运动功能改善
Huang等^[30](2018)	25/13	61.2±9.4	(25.9±18.1) d	RCT	健侧下肢皮质运动区	每次15 min, 每天1次，共15 d	1	双锥形	120%AMT	TUGT，PASS， FMA-LE，BI， SS-QOL，MEP	下肢平衡、运动无明显改善；假刺激组健侧半球皮质兴奋性增加
Lin等^[31](2015)	22/10	18~80	10~90 d	RCT	健侧M1区	每次15 min, 每天1次，共15 d	1	“8”字形	80%	PASS，POMA-b，FMA-LE，BI，TUGT	亚急性期脑卒中患者的平衡、日常生活活动及步行功能改善
黄长耀等^[32](2018)	19/11	60.67±10.95	< 1个月	RCT	健侧M1区	每次20 min, 每天1次，共10 d	1	“8”字形	80%	日本东京大学平衡量表，Tetrax平衡测试，MEP	站立平衡功能改善
Forogh等^[33](2017)	26/0	53~79	> 1个月	RCT	健侧M1区	每次20 min，每天1次，共5 d	1	“8”字形	90%	FMA-LE，BBS，下肢徒手肌力测试，静态平衡能力	提高下肢协调和运动功能，改善下肢肌力
Wang等^[34](2012)	—	62.98±10.88	> 6个月	RCT	健侧下肢皮质运动区	每次10 min，每天1次，每周5 d，共2周	1	“8”字形	90%	MEP，FMA-LE，步态分析	运动控制和行走能力改善
Naghdi等^[35](2015)	6/1	42~78	> 6个月	前后测试验	健侧下肢皮质运动区	每次20 min，每天1次，共5 d	1	“8”字形	100%	MAS，H反射，MEP，FMA-LE，TUGT	肌张力降低，运动功能改善
Kim等^[36](2014)	32/0	> 18	< 3个月	RCT	健侧小脑	每次15 min，每天1次，共5 d，	1	“8”字形	100%	10MWT，BBS	10MWT、BBS均明显改善

表3

参考文献 47

[1]	VIRANI S S, ALONSO A, BENJAMIN E J, et al. Heart Disease and Stroke Statistics-2020 Update: a report from the American Heart Association[J]. Circulation, 2020, 141(9): e139-e596.
[2]	PRESTON E, ADA L, DEAN C M, et al. What is the probability of patients who are nonambulatory after stroke regaining independent walking? A systematic review[J]. Int J Stroke, 2011, 6(6): 531-540. doi: 10.1111/j.1747-4949.2011.00668.x pmid: 22111798
[3]	GRAU-PELLICER M, CHAMARRO-LUSAR A, MEDINA-CASANOVAS J, et al. Walking speed as a predictor of community mobility and quality of life after stroke[J]. Top Stroke Rehabil, 2019, 26(5): 349-358. doi: 10.1080/10749357.2019.1605751
[4]	MINET L R, PETERSON E, VON KOCH L, et al. Occurrence and predictors of falls in people with stroke: six-year prospective study[J]. Stroke, 2015, 46(9): 2688-2690. doi: 10.1161/STROKEAHA.115.010496 pmid: 26243230
[5]	HILL G, REGAN S, FRANCIS R. Research priorities to improve stroke outcomes[J]. Lancet Neurol, 2022, 21(4): 312-313. doi: 10.1016/S1474-4422(22)00044-8 pmid: 35305334
[6]	GITTLER M, DAVIS A M. Guidelines for Adult Stroke Rehabilitation and Recovery[J]. JAMA, 2018, 319(8): 820-821. doi: 10.1001/jama.2017.22036 pmid: 29486016
[7]	MALENKA R C, BEAR M F. LTP and LTD: an embarrassment of riches[J]. Neuron, 2004, 44(1): 5-21. doi: 10.1016/j.neuron.2004.09.012 pmid: 15450156
[8]	SIEBNER H R, HARTWIGSEN G, KASSUBA T, et al. How does transcranial magnetic stimulation modify neuronal activity in the brain? Implications for studies of cognition[J]. Cortex, 2009, 45(9): 1035-1042. doi: 10.1016/j.cortex.2009.02.007 pmid: 19371866
[9]	CIRILLO G, DI PINO G, CAPONE F, et al. Neurobiological after-effects of non-invasive brain stimulation[J]. Brain Stimulation, 2017, 10(1): 1-18. doi: S1935-861X(16)30310-2 pmid: 27931886
[10]	WANG H Y, CRUPI D, LIU J, et al. Repetitive transcranial magnetic stimulation enhances BDNF-TrkB signaling in both brain and lymphocyte[J]. J Neurosci, 2011, 31(30): 11044-11054. doi: 10.1523/JNEUROSCI.2125-11.2011
[11]	KROGH S, JONSSON A B, AAGAARD P, et al. Efficacy of repetitive transcranial magnetic stimulation for improving lower limb function in individuals with neurological disorders: a systematic review and meta-analysis of randomized sham-controlled trials[J]. J Rehabil Med, 2022, 54: jrm00256. doi: 10.2340/jrm.v53.1097
[12]	LIU Y, LI H, ZHANG J, et al. A meta-analysis: whether repetitive transcranial magnetic stimulation improves dysfunction caused by stroke with lower limb spasticity[J]. Evid Based Complement Alternat Med, 2021, 2021: 7219293.
[13]	FAN H, SONG Y, CEN X, et al. The effect of repetitive transcranial magnetic stimulation on lower-limb motor ability in stroke patients: a systematic review[J]. Front Hum Neurosci, 2021, 15: 620573. doi: 10.3389/fnhum.2021.620573
[14]	TRICCO A C, LILLIE E, ZARIN W, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation[J]. Ann Intern Med, 2018, 169(7): 467-473. doi: 10.7326/M18-0850 pmid: 30178033
[15]	CASHIN A G, MCAULEY J H. Clinimetrics: Physiotherapy Evidence Database (PEDro) Scale[J]. J Physiother, 2020, 66(1): 59. doi: S1836-9553(19)30092-X pmid: 31521549
[16]	KAKUDA W, ABO M, WATANABE S, et al. High-frequency rTMS applied over bilateral leg motor areas combined with mobility training for gait disturbance after stroke: a preliminary study[J]. Brain Inj, 2013, 27(9): 1080-1086. doi: 10.3109/02699052.2013.794973 pmid: 23834634
[17]	杨露, 盛扬, 谢亮, 等. 重复经颅磁刺激联合康复训练对脑卒中患者步行功能的影响[J]. 中华物理医学与康复杂志, 2016, 38(12): 907-909.
[18]	CHA H G, KIM M K. Effects of strengthening exercise integrated repetitive transcranial magnetic stimulation on motor function recovery in subacute stroke patients: a randomized controlled trial[J]. Technol Health Care, 2017, 25(3): 521-529. doi: 10.3233/THC-171294 pmid: 28106573
[19]	CHIEFFO R, GIATSIDIS F, SANTANGELO R, et al. Repetitive transcranial magnetic stimulation with H-coil coupled with cycling for improving lower limb motor function after stroke: an exploratory study[J]. Neuromodulation, 2021, 24(5): 916-922. doi: 10.1111/ner.13228
[20]	JI S G, SHIN Y J, KIM M K. The effects of repetitive transcranial magnetic stimulation on balance ability in acute stroke patients[J]. J Korean Soc Phys Med, 2016, 11(3): 11-17.
[21]	CHIEFFO R, DE PREZZO S, HOUDAYER E, et al. Deep repetitive transcranial magnetic stimulation with H-coil on lower limb motor function in chronic stroke: a pilot study[J]. Arch Phys Med Rehabil, 2014, 95(6): 1141-1147. doi: 10.1016/j.apmr.2014.02.019
[22]	杨阳, 胡利杰, 蔡西国, 等. 重复经颅磁刺激对脑卒中下肢痉挛患者肢体功能恢复的影响[J]. 中华物理医学与康复杂志, 2015, 37(8): 602-603.
[23]	SASAKI N, ABO M, HARA T, et al. High-frequency rTMS on leg motor area in the early phase of stroke[J]. Acta Neurol Belg, 2017, 117(1): 189-194. doi: 10.1007/s13760-016-0687-1 pmid: 27502413
[24]	CHOI C M, KIM J H, LEE J K, et al. Effects of repetitive transcranial magnetic stimulation over trunk motor spot on balance function in stroke patients[J]. Ann Rehabil Med, 2016, 40(5): 826-834. doi: 10.5535/arm.2016.40.5.826
[25]	WANG R Y, WANG F Y, HUANG S F, et al. High-frequency repetitive transcranial magnetic stimulation enhanced treadmill training effects on gait performance in individuals with chronic stroke: a double-blinded randomized controlled pilot trial[J]. Gait Posture, 2019, 68: 382-387. doi: 10.1016/j.gaitpost.2018.12.023
[26]	KAKUDA W, ABO M, NAKAYAMA Y, et al. High-frequency rTMS using a double cone coil for gait disturbance[J]. Acta Neurol Scand, 2013, 128(2): 100-106. doi: 10.1111/ane.12085 pmid: 23398608
[27]	GOH H T, CONNOLLY K, HARDY J, et al. Single session of repetitive transcranial magnetic stimulation to left dorsolateral prefrontal cortex increased dual-task gait speed in chronic stroke: a pilot study[J]. Gait Posture, 2020, 78: 1-5. doi: 10.1016/j.gaitpost.2020.02.020
[28]	RASTGOO M, NAGHDI S, NAKHOSTIN ANSARI N, et al. Effects of repetitive transcranial magnetic stimulation on lower extremity spasticity and motor function in stroke patients[J]. Disabil Rehabil, 2016, 38(19): 1918-1926. doi: 10.3109/09638288.2015.1107780 pmid: 26878554
[29]	李亚梅, 黄林, 张晶, 等. 重复经颅磁刺激对脑梗死患者下肢运动功能的影响[J]. 中华物理医学与康复杂志, 2016, 38(11): 839-842.
	LI Y M, HUANG L, ZHANG J, et al. Effect of repetitive transcranial magnetic stimulation on lower limbmotor function of cerebral infarction patients[J]. Chin J Phys Med Rehabil, 2016, 38(11): 839-842.
[30]	HUANG Y Z, LIN L F, CHANG K H, et al. Priming with 1-Hz repetitive transcranial magnetic stimulation over contralesional leg motor cortex does not increase the rate of regaining ambulation within 3 months of stroke: a randomized controlled trial[J]. Am J Phys Med Rehabil, 2018, 97(5): 339-345. doi: 10.1097/PHM.0000000000000850
[31]	LIN Y N, HU C J, CHI J Y, et al. Effects of repetitive transcranial magnetic stimulation of the unaffected hemisphere leg motor area in patients with subacute stroke and substantial leg impairment: a pilot study[J]. J Rehabil Med, 2015, 47(4): 305-310. doi: 10.2340/16501977-1943
[32]	黄长耀, 窦佳鸣, 王丽婷, 等. 重复经颅磁刺激对脑卒中患者平衡功能影响的研究[J]. 中国康复医学杂志, 2018, 33(2): 165-169.
	HUANG C Y, DOU J M, WANG L T, et al. Effects of repetitive transcranial magnetic stimulation on balance function in stroke patients[J]. Chin J Rehabil Med, 2018, 33(2): 165-169.
[33]	FOROGH B, AHADI T, NAZARI M, et al. The effect of repetitive transcranial magnetic stimulation on postural stability after acute stroke: a clinical trial[J]. Basic Clin Neurosci, 2017, 8(5): 405-411. doi: 10.18869/nirp.bcn.8.5.405 pmid: 29167727
[34]	WANG R Y, TSENG H Y, LIAO K K, et al. rTMS combined with task-oriented training to improve symmetry of interhemispheric corticomotor excitability and gait performance after stroke: a randomized trial[J]. Neurorehabil Neural Repair, 2012, 26(3): 222-230. doi: 10.1177/1545968311423265
[35]	NAGHDI S, ANSARI N N, RASTGOO M, et al. A pilot study on the effects of low frequency repetitive transcranial magnetic stimulation on lower extremity spasticity and motor neuron excitability in patients after stroke[J]. J Bodyw Mov Ther, 2015, 19(4): 616-623. doi: 10.1016/j.jbmt.2014.10.001 pmid: 26592218
[36]	KIM W S, JUNG S H, OH M K, et al. Effect of repetitive transcranial magnetic stimulation over the cerebellum on patients with ataxia after posterior circulation stroke: a pilot study[J]. J Rehabil Med, 2014, 46(5): 418-423. doi: 10.2340/16501977-1802
[37]	SHIMIZU T, HOSAKI A, HINO T, et al. Motor cortical disinhibition in the unaffected hemisphere after unilateral cortical stroke[J]. Brain, 2002, 125(Pt 8): 1896-1907. doi: 10.1093/brain/awf183 pmid: 12135979
[38]	HUYNH W, VUCIC S, KRISHNAN A V, et al. Exploring the evolution of cortical excitability following acute stroke[J]. Neurorehabil Neural Repair, 2016, 30(3): 244-257. doi: 10.1177/1545968315593804 pmid: 26150146
[39]	HARRINGTON R M, CHAN E, ROUNDS A K, et al. Roles of lesioned and nonlesioned hemispheres in reaching performance poststroke[J]. Neurorehabil Neural Repair, 2020, 34(1): 61-71. doi: 10.1177/1545968319876253 pmid: 31858870
[40]	DIJKSTRA B W, BEKKERS E M J, GILAT M, et al. Functional neuroimaging of human postural control: a systematic review with meta-analysis[J]. Neurosci Biobehav Rev, 2020, 115: 351-362. doi: S0149-7634(20)30393-6 pmid: 32407735
[41]	WITTKOPF P G, LARSEN D B, GRAVEN-NIELSEN T. Protocols for inducing homeostatic plasticity reflected in the corticospinal excitability in healthy human participants: a systematic review and meta-analysis[J]. Eur J Neurosci, 2021, 54(4): 5444-5461. doi: 10.1111/ejn.15389 pmid: 34251703
[42]	THOMSON R H, ROGASCH N C, MALLER J J, et al. Intensity dependent repetitive transcranial magnetic stimulation modulation of blood oxygenation[J]. J Affect Disord, 2012, 136(3): 1243-1246. doi: 10.1016/j.jad.2011.08.005
[43]	HODAJ H, PAYEN J F, LEFAUCHEUR J P. Therapeutic impact of motor cortex rTMS in patients with chronic neuropathic pain even in the absence of an analgesic response. A case report[J]. Neurophysiol Clin, 2018, 48(5): 303-308. doi: S0987-7053(18)30065-0 pmid: 29910145
[44]	WILSON M T, ST GEORGE L. Repetitive transcranial magnetic stimulation: a call for better data[J]. Front Neural Circuits, 2016, 10: 57.
[45]	DENG Z D, LISANBY S H, PETERCHEV A V. Coil design considerations for deep transcranial magnetic stimulation[J]. Clin Neurophysiol, 2014, 125(6): 1202-1212. doi: 10.1016/j.clinph.2013.11.038
[46]	ABERRA A S, WANG B, GRILL W M, et al. Simulation of transcranial magnetic stimulation in head model with morphologically-realistic cortical neurons[J]. Brain Stimul, 2020, 13(1): 175-189. doi: S1935-861X(19)30409-7 pmid: 31611014
[47]	OPIE G M, VOSNAKIS E, RIDDING M C, et al. Priming theta burst stimulation enhances motor cortex plasticity in young but not old adults[J]. Brain Stimul, 2017, 10(2): 298-304. doi: S1935-861X(17)30003-7 pmid: 28089653

纳入文献	纳入条件	随机分配	分配隐藏	基线相似	受试者	干预人员	评估人员	完成实验	干预意向	统计结果	测量值	总分
Kakuda等^[16](2013)	√			√	√		√	√	√	√	√	7
杨露等^[17](2016)	√	√		√	√		√	√	√	√	√	8
Cha等^[18](2017)	√	√	√	√	√	√	√		√	√	√	9
Chieffo等^[19](2021)	√			√	√		√	√	√	√	√	7
Ji等^[20](2016)	√	√	√	√			√	√	√	√	√	8
Chieffo等^[21](2014)	√	√	√	√	√		√	√	√	√	√	9
杨阳等^[22](2015)	√	√		√			√	√	√	√	√	7
Sasaki等^[23](2017)	√	√		√	√		√	√	√	√	√	8
Choi等^[24](2016)	√	√	√	√	√	√			√	√	√	8
Wang等^[25](2019)	√	√		√	√		√	√	√	√	√	8
Kakuda等^[26](2013)	√			√				√	√	√	√	5
Goh等^[27](2020)	√			√				√	√	√	√	5
Rastgoo等^[28](2016)	√	√		√	√				√	√	√	6
李亚梅等^[29](2016)	√	√		√			√	√	√	√	√	7
Huang等^[30](2018)	√	√		√	√		√	√	√	√	√	8
Lin等^[31](2015)	√	√		√	√		√	√	√	√	√	8
黄长耀等^[32](2018)	√	√		√	√		√	√	√	√	√	8
Forogh等^[33](2017)	√	√		√	√		√	√	√	√	√	8
Wang等^[34](2012)	√	√	√	√	√		√	√	√	√	√	9
Naghdi等^[35](2015)	√			√				√	√	√	√	5
Kim等^[36](2014)	√	√		√	√		√	√	√	√	√	8

重复经颅磁刺激治疗脑卒中后下肢运动功能障碍的Scoping综述

Repetitive transcranial magnetic stimulation for lower limb dysfunction post stroke: a scoping review

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 4

参考文献 47

相关文章 15

Metrics

本文评价

推荐阅读 0

[1]	邵伟婷, 雷江华. 反应中断再定向干预孤独症谱系障碍儿童刻板语言的效果：Scoping综述[J]. 《中国康复理论与实践》, 2024, 30(1): 10-20.
[2]	林娜, 高菡璐, 卢惠苹, 陈燕清, 郑军凡, 陈述荣. 虚拟现实技术对脑卒中上肢功能影响的弥散张量成像研究[J]. 《中国康复理论与实践》, 2024, 30(1): 61-67.
[3]	王昊懿, 史亚伟, 鲁俊, 许光旭. 主观垂直感知障碍对脑卒中患者功能影响的回顾性研究[J]. 《中国康复理论与实践》, 2024, 30(1): 68-73.
[4]	陈珺雯, 陈谦, 陈程, 李淑月, 刘玲玲, 吴存书, 龚翔, 鲁俊, 许光旭. 改良八段锦身体活动对脑卒中患者心肺功能、运动功能和日常生活活动能力的效果[J]. 《中国康复理论与实践》, 2024, 30(1): 74-80.
[5]	胡永林, 马颖, 窦超, 陆安民, 江小鸽, 宋新建, 肖玉华. 肩部控制训练联合神经松动术对脑卒中偏瘫患者肩痛及上肢功能的效果[J]. 《中国康复理论与实践》, 2024, 30(1): 81-86.
[6]	刘冬, 徐子涵, 李江, 鞠萍. M1区联合背外侧前额叶高频重复经颅磁刺激对脊髓损伤后神经病理性疼痛患者脑电图θ振幅的效果[J]. 《中国康复理论与实践》, 2024, 30(1): 87-94.
[7]	王贺, 韩靓, 阚梦凡, 于少泓. 电刺激治疗脑卒中后肩手综合征有效性的系统评价与Meta分析[J]. 《中国康复理论与实践》, 2023, 29(9): 1048-1056.
[8]	孙藤方, 任梦婷, 杨琳, 王耀霆, 王红雨, 闫兴洲. 高压氧治疗联合重复外周磁刺激干预脑卒中患者踝运动功能和平衡能力的效果[J]. 《中国康复理论与实践》, 2023, 29(8): 875-881.
[9]	王亚楠, 刘西花. 脑卒中偏瘫患者主观和客观平衡功能测量的相关性及预测效能[J]. 《中国康复理论与实践》, 2023, 29(8): 890-895.
[10]	王海云, 王寅, 周信杰, 何爱群. 基于“中枢-外周-中枢”理论的经颅直流电刺激结合针刺干预脑卒中患者中枢及上肢功能的效果[J]. 《中国康复理论与实践》, 2023, 29(8): 919-925.
[11]	陈怡婷, 王倩, 崔慎红, 李映彩, 张思鈺, 魏衍旭, 任慧, 冷军, 陈斌. 双侧序贯重复经颅磁刺激干预脑卒中患者上肢运动功能的效果[J]. 《中国康复理论与实践》, 2023, 29(8): 926-932.
[12]	李振亚, 孙洁, 郭鹏飞, 王光明. 脑卒中患者口期和咽期吞咽功能改变与误吸的相关性：基于电视透视吞咽检查[J]. 《中国康复理论与实践》, 2023, 29(8): 933-939.
[13]	蒙象强, 熊琪, 陈庚发, 白洋, 邹田子, 冯珍. 经颅磁刺激联合正中神经电刺激干预不同年龄段慢性意识障碍的效果[J]. 《中国康复理论与实践》, 2023, 29(8): 940-947.
[14]	李芳, 霍速, 杜巨豹, 刘秀贞, 李小爽, 宋为群. 经颅直流电刺激联合任务导向性康复训练对脊髓损伤大鼠前肢运动障碍的效果[J]. 《中国康复理论与实践》, 2023, 29(7): 777-781.
[15]	崔尧, 丛芳, 黄富表, 曾明, 颜如秀. 不同镜像神经元训练策略下脑与肌肉的活动特征：基于近红外光谱与表面肌电图技术[J]. 《中国康复理论与实践》, 2023, 29(7): 782-790.