《中国康复理论与实践》

《中国康复理论与实践》 ›› 2023, Vol. 29 ›› Issue (12): 1405-1419.doi: 10.3969/j.issn.1006-9771.2023.12.005

• 专题 康复循证研究 • 上一篇    下一篇

脑卒中领域功能性近红外光谱技术研究的可视化分析

王海芳1, 徐敏杰1, 李颖1, 雷筱菁2, 常静玲1()   

  1. 1.北京中医药大学东直门医院神经内科，北京市 100700
    2.陕西中医药大学，陕西咸阳市 712046
  • 收稿日期:2023-08-08 修回日期:2023-10-26 出版日期:2023-12-25 发布日期:2023-12-28
  • 通讯作者: 常静玲(1970-)，女，博士，主任医师、教授，博士研究生导师，主要研究方向：中医药防治脑病。E-mail： ear6979@163.com
  • 作者简介:王海芳(1991-)，女，汉族，山东聊城市人，博士研究生，主要研究方向：中医药防治脑病。
  • 基金资助:
    1.国家自然科学基金项目(81973790);2.中央高校重点项目(2022-JYB-JBZR-032)

Application of functional near-infrared spectroscopy in stroke: a visualized analysis

WANG Haifang1, XU Minjie1, LI Ying1, LEI Xiaojing2, CHANG Jingling1()   

  1. 1. Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
    2. Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China
  • Received:2023-08-08 Revised:2023-10-26 Published:2023-12-25 Online:2023-12-28
  • Contact: CHANG Jingling, E-mail: ear6979@163.com
  • Supported by:
    National Natural Science Foundation of China(81973790);Fundamental Research Funds for the Central Universities(2022-JYB-JBZR-032)

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摘要：

目的 探讨功能性近红外光谱技术(fNIRS)在脑卒中领域的研究现状和前沿热点。

方法 检索Web of Science Core Collection (WoSCC)数据库建库至2023年7月有关脑卒中和fNIRS的相关文献。采用VOSviewer、CiteSpace和Scimago软件对发文量、国家(地区)和机构、国际合作、共引参考文献、共现关键词和突发关键词进行分析。

结果 共纳入379篇文献。该领域研究热度总体呈上升趋势，但研究前期略有波动。发文量前5的机构中中国的机构占据4位。共现分析显示北京航空航天大学和波士顿儿童医院两个机构在合作关系中处于中心地位。本研究中涉及1 787位作者，核心作者120位，最常被引用的前5位作者分别是Li Zengyong、Li Wenhao、Huo Congcong、Dou Zulin和Song Ying。该领域发表期刊主要集中在神经学、精神学、眼科学、临床医学等学科。期刊双图叠加显示，医学、临床和神经病学等学科与心理学、教育学、社会学等学科之间存在一定关联。关键词共现与聚类分析表明，研究聚焦于脑卒中康复，整合多种技术模式，强调创新训练策略和脑区激活连接的探索。fNIRS在脑卒中领域的研究进展显示，初期采用光电二极管设备用于脑缺血再灌注监测。随后，通过改进激光光源、雪崩二极管、单一任务实验设计和经颅直流电刺激等手段，进行皮质激活的精细研究。此后，研究拓展至全脑检测、多模态刺激以及虚拟现实技术与视听刺激相结合，显著增强了脑区激活效果。直至脑机接口技术的应用促进运动功能的直接修复。

结论 fNIRS技术在脑卒中领域研究总体呈上升趋势，研究重点为脑卒中后的康复，结合多模态融合、脑-机接口和虚拟现实与感官刺激等技术实现实时监测与个性化神经康复训练策略，注重多学科交叉、创新研究拓展与新技术应用。

关键词: 脑卒中, 功能性近红外光谱, 知识图谱, 文献计量学

Abstract:

Objective To explore the current status and frontier hotspots of functional near-infrared spectroscopy (fNIRS) in the field of stroke.

Methods Relevant literature on stroke and fNIRS from the Web of Science Core Collection (WoSCC) database was searched from its inception to July, 2023. VOSviewer, CiteSpace and Scimago were utilized for analysis of publication output, countries (regions) and institutions, international collaboration, co-cited references, co-occurring keywords and burst keywords.

Results A total of 379 articles were included. The research activity in this field showed an overall upward trend with slight fluctuations in the early stage. Among the top five institutions by publication output, four were from China. Co-occurrence analysis revealed that Beihang University and Boston Children's Hospital were central in collaboration networks. This study involved 1 787 authors, with 120 core authors, in which the top five most cited authors were Li Zengyong, Li Wenhao, Huo Congcong, Dou Zulin and Song Ying. The publications in this field were primarily concentrated in disciplines such as neurology, psychiatry, ophthalmology and clinical medicine. Overlay visualization of journal co-citation networks demonstrated associations between medical, clinical, and neurology disciplines with psychology, education, and sociology. Co-occurrence and clustering analysis of keywords indicated research emphasis on stroke rehabilitation, integration of multiple technical modalities, and exploration of innovative training strategies and brain activation connectivity. The research evolution of fNIRS in the stroke domain revealed initial use of photodiode devices for cerebral ischemia reperfusion monitoring. Subsequent studies refined cortical activation through improved laser sources, avalanche photodiodes, single-task experimental designs and transcranial direct current stimulation. Later, research extended to whole-brain detection, multimodal stimulation and the combination of virtual reality technology with audiovisual stimulation, resulting in significantly enhanced brain activation. The application of brain-computer interface technology further facilitated direct restoration of motor function.

Conclusion Researches in the field of stroke using fNIRS technology overall demonstrat a continuous upward trend. The researches focuse on post-stroke rehabilitation, integrating multimodal fusion, brain-computer interfaces, virtual reality, and sensory stimulation for real-time monitoring and personalized neurorehabilitation training strategies. It emphasizes interdisciplinary collaboration, expanding innovative research and the application of new technologies.

Key words: stroke, functional near-infrared spectroscopy, knowledge map, bibliometrics

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