《中国康复理论与实践》

《中国康复理论与实践》 ›› 2025, Vol. 31 ›› Issue (2): 194-208.doi: 10.3969/j.issn.1006-9771.2025.02.009

• 循证研究 • 上一篇    下一篇

非侵入性脑刺激在阿尔茨海默病中应用的文献计量分析

张琦1, 孙文玉2, 高振梅2(), 刘睿1, 张天奥1   

  1. 1.山东中医药大学康复医学院，山东济南市 250355
    2.山东中医药大学附属医院康复理疗科，山东济南市 250012
  • 收稿日期:2024-11-27 修回日期:2024-12-30 出版日期:2025-02-25 发布日期:2025-02-25
  • 通讯作者: 高振梅(1981-)，女，汉族，山东潍坊市人，硕士，副主任医师，研究生导师，主要研究方向：神经系统疾病中西医康复理论体系研究与临床研究，E-mail： gzmzjy@126.com。
  • 作者简介:张琦(1997-)，男，汉族，河南辉县市人，硕士研究生，主要研究方向：神经系统疾病中西医康复理论体系研究与临床研究。
  • 基金资助:
    1.国家自然科学基金项目(82374311);2.山东省中医药高层次人才培育项目(鲁卫函[2022]148号);3.山东中医药大学附属医院项目(H20230227-01)

Application of non-invasive brain stimulation in Alzheimer's disease: a bibliometrics analysis

ZHANG Qi1, SUN Wenyu2, GAO Zhenmei2(), LIU Rui1, ZHANG Tianao1   

  1. 1. College of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong 250355, China
    2. Department of Rehabilitation Physiotherapy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong 250012, China
  • Received:2024-11-27 Revised:2024-12-30 Published:2025-02-25 Online:2025-02-25
  • Contact: GAO Zhenmei, E-mail: gzmzjy@126.com
  • Supported by:
    National Natural Science Foundation of China(82374311);Shandong Traditional Chinese Medicine High-level Talents Training Project(Lu Weihan [2022] 148);Affiliated Hospital of Shandong University of Traditional Chinese Medicine Project(H20230227-01)

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摘要：

目的 分析非侵入性脑刺激(NIBS)在阿尔茨海默病中应用的研究热点和未来趋势。

方法 检索2014年1月至2024年10月Web of Science核心合集数据库中有关NIBS在阿尔茨海默病中应用的相关文献。采用CiteSpace 6.4.R1对纳入文献的年发文量、国家、机构、作者、关键词、共被引文献进行可视化分析并绘制知识图谱。

结果 共纳入731篇文献，年发文量呈上升趋势，美国是发文量最多的国家，Harvard University是高产机构，Giacomo Koch是高产作者，Brain Stimulation是引用频次最多的期刊。关注度较高的关键词主要为认知障碍、记忆、痴呆、经颅磁刺激、经颅直流电刺激等。近两年出现的突现词主要为经颅交流电刺激、功能磁共振成像、脑源性神经营养因子和氧化应激。

结论 NIBS在阿尔茨海默病领域的研究热度呈现逐年上升趋势，研究热点包括NIBS对认知功能的影响及作用机制，以及刺激不同脑区对认知功能的影响。未来与功能磁共振成像等技术结合实现个体化和精准化刺激可能是该领域的研究趋势。

关键词: 阿尔茨海默病, 非侵入性脑刺激, 经颅脉冲刺激, 文献计量学

Abstract:

Objective To analyze the research hotspot and future trend of non-invasive brain stimulation (NIBS) in Alzheimer's disease.

Methods Relevant literature on application of NIBS in Alzheimer's disease from January, 2014 to October, 2024 was retrieved from the Web of Science Core Collection database. CiteSpace 6.4.R1 was used to perform a bibliometric analysis and to create knowledge maps, including annual publication volume, countries, institutions, authors, keywords and co-cited references.

Results A total of 731 articles were included, showing an increasing trend in annual publication volume. The United States was the leading country in publication volume, Harvard University was the most productive institution, and Giacomo Koch was the most prolific author. Brain Stimulation was the most frequently cited journal. Highly focused keywords included cognitive impairment, memory, dementia, transcranial magnetic stimulation and transcranial direct current stimulation. Bursting keywords in the past two years included transcranial alternating current stimulation, functional magnetic resonance imaging, brain-derived neurotrophic factor and oxidative stress.

Conclusion Research interest in NIBS within the field of Alzheimer's disease has been steadily increasing. The research hotspots include the effect and mechanism of NIBS on cognitive function and the impact of stimulating different brain regions on cognitive outcome. Future research may focus on integrating NIBS with techniques such as functional magnetic resonance imaging to achieve individualized and precise stimulation.

Key words: Alzheimer's disease, non-invasive brain stimulation, transcranial pulse stimulation, bibliometrics

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