不同时序经颅直流电刺激结合坐位太极拳云手对健康青年人脑皮质激活的功能性近红外光谱研究

doi:10.3969/j.issn.1006-9771.2025.10.003

《中国康复理论与实践》 ›› 2025, Vol. 31 ›› Issue (10): 1128-1133.doi: 10.3969/j.issn.1006-9771.2025.10.003

• 专题　脑-肢体协同的功能性近红外光谱研究 • 上一篇下一篇

不同时序经颅直流电刺激结合坐位太极拳云手对健康青年人脑皮质激活的功能性近红外光谱研究

王俊伟¹, 许琦¹^,²(), 王欣欣¹, 何毅琪², 吴心虹², 张芸²

1.厦门医学院临床医学院，福建厦门市 361023
2.厦门市第五医院，福建厦门市 361101

收稿日期:2025-07-23 修回日期:2025-09-16 出版日期:2025-10-25 发布日期:2025-11-10
通讯作者: 许琦(1974-)，女，汉族，福建松溪县人，博士，研究员、医师，主要研究方向：神经康复、骨科康复、运动损伤康复，E-mail： dptqixu@126.com
作者简介:王俊伟(2004-)，男，汉族，安徽肥西县人，本科生。
基金资助:
福建省科技计划项目(2022Y01020084)

Effect of transcranial direct current stimulation combined with seated Taijiquan Yunshou in different sequences on cerebral cortical activation for healthy youths: a functional near-infrared spectroscopy study

WANG Junwei¹, XU Qi¹^,²(), WANG Xinxin¹, HE Yiqi², WU Xinhong², ZHANG Yun²

1. Department of Clinical Medicine, Xiamen Medical College, Xiamen, Fujian 361023, China
2. The Fifth Hospital of Xiamen, Xiamen, Fujian 361101, China

Received:2025-07-23 Revised:2025-09-16 Published:2025-10-25 Online:2025-11-10
Contact: XU Qi, E-mail: dptqixu@126.com
Supported by:
Fujian Science and Technology Program(2022Y01020084)

摘要/Abstract

摘要：

目的观察不同时序经颅直流电刺激(tDCS)与坐位太极拳云手干预组合对健康青年大脑皮质激活的影响。
方法 2024年9月至12月，在厦门市第五医院招募健康青年实习或见习医学生14例，随机交叉完成3种干预：先进行云手训练后，立即给予tDCS(云-电组)；先给予tDCS干预后，立即进行云手训练(电-云组)；tDCS干预与云手训练同时进行(同步组)。云手为坐位练习，tDCS阳极置于左侧初级运动皮质(M1)，阴极置于右侧M1。采用功能性近红外光谱测量感兴趣区氧合血红蛋白(HbO₂)浓度的变化。
结果 3例脱落。干预前后有显著性差异的脑区包括：云-电组右前额叶皮质(PFC)的CH3、CH7、CH23通道；电-云组左PFC的CH12通道；同步组左PFC的CH9、CH10、CH25，左感觉运动皮质(SMC)的CH13、CH14，右前运动及辅助运动皮质(PMC)区的CH15和右SMC的CH16等(P < 0.05)。干预后，云-电组双侧PFC、双侧PMC和左SMC的HbO₂浓度最高(P < 0.05)；除右PFC同步组HbO₂浓度降低外，同步组HbO₂浓度与电-云组大致相当(P > 0.05)。
结论脑-肢体协同调控的时序组合是调控脑激活即时模式的关键因素。

关键词: 经颅直流电刺激, 太极拳, 云手, 皮质激活, 时序组合模式, 功能性近红外光谱, 脑-肢体协同调控技术

Abstract:

Objective To compare the effect of transcranial direct current stimulation (tDCS) combined with seated Taijiquan Yunshou in different sequences on brain functional activation in healthy youths.
Methods From September to December, 2024, 14 healthy young medical interns or probationers were recruited from the Fifth Hospital of Xiamen. They randomly completed three interventions in a crossover design: Yunshou training followed immediately by tDCS (Y-S group), tDCS intervention followed immediately by Yunshou training (S-Y group), and simultaneous implementation of tDCS intervention and Yunshou training (Sim group). Yunshou was practiced in a seated position. For tDCS, the anode was placed over the left primary motor cortex (M1), and the cathode over the right M1. Changes in oxyhemoglobin (HbO₂) concentration in the regions of interest were measured using functional near-infrared spectroscopy.
Results Three cases dropped down. The brain regions with significant differences before and after intervention included: CH3, CH7 and CH23 of right prefrontal cortex (PFC) in Y-S group; CH12 of left PFC in S-Y group; and CH9, CH10 and CH25 of the left PFC, CH13 and CH14 of the left sensorimotor cortex (SMC), CH15 of the right premotor and supplementary motor cortex (PMC), and CH16 of the right SMC in Sim group (P < 0.05). After intervention, HbO₂ concentration was the highest in the bilateral PFC, bilateral PMC and left SMC in the Y-S group (P < 0.05); and it was almost the same between Sim group and S-Y group (P > 0.05), except that of the right PFC decreased in Sim group.
Conclusion The sequential combination of brain-limb integrated regulation is a key factor influencing the immediate cortical activation pattern.

Key words: transcranial direct current stimulation, Taijiquan, Yunshou, cortical activation, sequential combination pattern, functional near-infrared spectroscopy, brain-limb coordinated rehabilitation

中图分类号:

R493

王俊伟, 许琦, 王欣欣, 何毅琪, 吴心虹, 张芸. 不同时序经颅直流电刺激结合坐位太极拳云手对健康青年人脑皮质激活的功能性近红外光谱研究[J]. 《中国康复理论与实践》, 2025, 31(10): 1128-1133.

WANG Junwei, XU Qi, WANG Xinxin, HE Yiqi, WU Xinhong, ZHANG Yun. Effect of transcranial direct current stimulation combined with seated Taijiquan Yunshou in different sequences on cerebral cortical activation for healthy youths: a functional near-infrared spectroscopy study[J]. Chinese Journal of Rehabilitation Theory and Practice, 2025, 31(10): 1128-1133.

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参考文献 30

[1]	HO J S, SLAWKA E, PACHECO-BARRIOS K, et al. The pros and cons of tDCS as a therapeutic tool in the rehabilitation of chronic pain[J]. Princ Pract Clin Res, 2022, 8(2): 26-30.
[2]	LEE C W, PARK K, AHN J E, et al. Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: a double-blind, randomized, multi-site clinical trial[J]. Eur Psychiatry, 2025, 68(1): e15. doi: 10.1192/j.eurpsy.2024.1811
[3]	王伟, 宋为群, 张艳明, 等. 经颅直流电刺激对脑卒中患者上肢运动功能康复的效果[J]. 中国康复理论与实践, 2021, 27(9): 1082-1086. doi: 10.3969/j.issn.1006-9771.2021.09.013
	WANG W, SONG W Q, ZHANG Y M, et al. Effect of transcranial direct current stimulation on upper limb motor function for patients with stroke[J]. Chin J Rehabil Theory Pract, 2021, 27 (9): 1082-1086.
[4]	张娜, 刘卉, 苗雨, 等. 经颅电刺激技术用于运动表现提升的研究进展[J]. 中国生物医学工程学报, 2022, 41(2): 214-223.
	ZHANG N, LIU H, MIAO Y, et al. Advance of transcranial electrical stimulation for the improvement of motor performance[J]. Chin J Biomed Eng, 2022, 41 (2): 214-223.
[5]	LAW N Y, LI J X. Biomechanics analysis of seven Tai Chi movements[J]. Sports Med Health Sci, 2022, 4(4): 245-252. doi: 10.1016/j.smhs.2022.06.002
[6]	YANG Y, CHEN T, SHAO M, et al. Effects of Tai Chi Chuan on inhibitory control in elderly women: an fNIRS study[J]. Front Hum Neurosci, 2019, 13: 476. doi: 10.3389/fnhum.2019.00476 pmid: 32038205
[7]	崔家宝, 林舰, 刘育成, 等. 大学生太极拳活动的心理健康效益:基于ICF的系统综述[J]. 中国康复理论与实践, 2023, 29(1): 48-54. doi: 10.3969/j.issn.1006-9771.2023.01.007
	CUI J B, LIN J, LIU Y C, et al. Mental health benefits of Tai Chi for college students: a systematic review using ICF[J]. Chin J Rehabil Theory Pract, 2023, 29 (1): 48-54.
[8]	SEFAT O, SALEHINEJAD M A, DANILEWITZ M, et al. Combined Yoga and transcranial direct current stimulation increase functional connectivity and synchronization in the frontal areas[J]. Brain Topogr, 2022, 35 (2): 207-218. doi: 10.1007/s10548-022-00887-z
[9]	MEHRDADIAN M, SAEMI E, BADICU G, et al. A selected balance exercise combined with anodal tDCS was beneficial in balance performance but not in working memory in healthy older adults[J]. J Motor Control Learn, 2023, 5(2): e144166.
[10]	DEVEZAS M Â M. Shedding light on neuroscience: two decades of functional near-infrared spectroscopy applications and advances from a bibliometric perspective[J]. J Neuroimaging, 2021, 31(4): 641-655. doi: 10.1111/jon.12877 pmid: 34002425
[11]	张宁, 杨远滨, 田浩林, 等. 功能性近红外光谱应用于康复领域的可视化分析[J]. 中国康复理论与实践, 2023, 29(10): 1171-1178. doi: 10.3969/j.issn.1006-9771.2023.10.008
	ZHANG N, YANG Y B, TIAN H L, et al. Application of functional near-infrared spectroscopy in rehabilitation: a visualized analysis[J]. Chin J Rehabil Theory Pract, 2023, 29(10): 1171-1178.
[12]	LIU D. Neural system regulation of athletes based on FNIRS and thermal radiation images: rehabilitation of motor function[J]. Therm Sci Eng Prog, 2025, 59: 103293.
[13]	联合国. 联合国青年议题[EB/OL]. (2024-12-30)[2025-09-16]. https://www.un.org/zh/events/youth/index.shtml.
[14]	OLDFIELD R C. The assessment and analysis of handedness: the Edinburgh inventory[J]. Neuropsychologia, 1971, 9(1): 97-113. doi: 10.1016/0028-3932(71)90067-4 pmid: 5146491
[15]	何晓阔, 刘慧华, 余果, 等. 经颅直流电刺激与功能性电刺激的不同时序组合对脑卒中偏瘫患者脑功能连接的即时影响[J]. 中国康复医学杂志, 2021, 36(10): 1213-1219.
	HE X K, LIU H H, YU G, et al. Short-term effects of different time sequences of transcranial direct current stimulation and functional electrical stimulation on brain functional connectivity in hemiplegic patients[J]. Chin J Rehabil Med, 2021, 36(10): 1213-1219.
[16]	PRABHU N M, LEHMANN N, KAMINSKI E, et al. Online stimulation of the prefrontal cortex during practice increases motor variability and modulates later cognitive transfer: a randomized, double-blinded and sham-controlled tDCS study[J]. Sci Rep, 2024, 14: 20162. doi: 10.1038/s41598-024-70857-x pmid: 39215020
[17]	DENG X, JIAN C, YANG Q, et al. The analgesic effect of different interactive modes of virtual reality: a prospective functional near-infrared spectroscopy (fNIRS) study[J]. Front Neurosci, 2022, 16: 1033155. doi: 10.3389/fnins.2022.1033155
[18]	吴媛媛, 闵瑜, 燕铁斌. Wolf运动功能测试量表评定脑卒中急性期患者上肢功能的效度和信度研究[J]. 中国康复医学杂志, 2009, 24(11): 992-994.
	WU Y Y, MIN Y, YAN T B. Validity and reliability of Wolf Motor Function Test on assessing the upper extremities motor function of Chinese stroke patients in acute stage[J]. Chin J Rehabil Med, 2009, 24(11): 992-994.
[19]	李秀丽, 李珊, 冯梦晨, 等. 采用上肢运动游戏治疗卒中后轻度认知障碍并结合功能性近红外光谱技术进行疗效评估的研究[J]. 中国康复, 2023, 38(7): 412-416.
	LI X L, LI S, FENG M C, et al. Application of functional near-infrared spectroscopy in effectiveness evaluation of upper limb exergames in the treatment of stroke patients with mild cognitive impairment[J]. Chin J Rehabil, 2023, 38 (7): 412-416.
[20]	DAI L, ZHANG W, ZHANG H, et al. Effects of robot-assisted upper limb training combined with intermittent theta burst stimulation (iTBS) on cortical activation in stroke patients: a functional near-infrared spectroscopy study[J]. NeuroRehabilitation, 2024, 54(3): 421-434. doi: 10.3233/NRE-230355 pmid: 38640179
[21]	XIA W, DAI R, XU X, et al. Cortical mapping of active and passive upper limb training in stroke patients and healthy people: a functional near-infrared spectroscopy study[J]. Brain Res, 2022, 1788: 147935. doi: 10.1016/j.brainres.2022.147935
[22]	YANG Z, YE L, YANG L, et al. Early screening of post-stroke fall risk: a simultaneous multimodal fNIRs-EMG study[J]. CNS Neurosci Ther, 2024, 30(9): e70041. doi: 10.1111/cns.v30.9
[23]	SOEKADAR S R, KOHL S H, MIHARA M, et al. Optical brain imaging and its application to neurofeedback[J]. Neuroimage Clin, 2021, 30: 102577. doi: 10.1016/j.nicl.2021.102577
[24]	CHEN Y, WAN A, MAO M, et al. Tai Chi practice enables prefrontal cortex bilateral activation and gait performance prioritization during dual-task negotiating obstacle in older adults[J]. Front Aging Neurosci, 2022, 14: 1000427. doi: 10.3389/fnagi.2022.1000427
[25]	STEINBERG F, PIXA N H, FREGNI F. A review of acute aerobic exercise and transcranial direct current stimulation effects on cognitive functions and their potential synergies[J]. Front Hum Neurosci, 2018, 12: 534. doi: 10.3389/fnhum.2018.00534 pmid: 30687048
[26]	桑林琼, 王莉, 乔梁, 等. 基于fNIRS的大脑前额叶皮层在不同脑力负荷下的激活模式研究[J]. 第三军医大学学报, 2022, 44(3): 210-216.
	SANG L Q, WANG L, QIAO L, et al. Load-dependent activation of bilateral prefrontal cortex: an fNIRS study[J]. J Third Mil Med Univ, 2022, 44 (3): 210-216.
[27]	LI L M, VIOLANTE I R, LEECH R, et al. Brain state and polarity dependent modulation of brain networks by transcranial direct current stimulation[J]. Hum Brain Mapp, 2019, 40(3): 904-915. doi: 10.1002/hbm.24420 pmid: 30378206
[28]	周治宁, 周容, 肖燕文, 等. 多靶区经颅直流电刺激对健康成年人工作记忆:姿势控制双任务表现的影响[J]. 中国康复理论与实践, 2024, 30(1): 21-28. doi: 10.3969/j.issn.1006-9771.2024.01.003
	ZHOU Z N, ZHOU R, XIAO Y W, et al. Effect of multi-target transcranial direct current stimulation on performance of working memory-postural control dual-task in healthy adults[J]. Chin J Rehabil Theory Pract, 2024, 30(1): 21-28.
[29]	KIM H, KIM J, LEE G, et al. Task-related hemodynamic changes induced by high-definition transcranial direct current stimulation in chronic stroke patients: an uncontrolled pilot fNIRS study[J]. Brain Sci, 2022, 12 (4): 453. doi: 10.3390/brainsci12040453
[30]	许琦, 张芸, 燕铁斌. 中西医结合脑-肢体协同调控技术治疗脑病的康复模式构建[J]. 中华中医药杂志, 2023, 38(11): 5357-5360.
	XU Q, ZHANG Y, YAN T B. Construction of rehabilitation model of brain-limb integrated therapy for treating encephalopathy based on integrated traditional Chinese and Western medicine[J]. Chin J Tradit Chin Med Pharm, 2023, 38 (11): 5357-5360.

ROI	n	通道
左PFC	9	CH8、CH9、CH10、CH11、CH12、CH24、CH25、CH26、CH27
右PFC	10	CH3、CH4、CH5、CH6、CH7、CH19、CH20、CH21、CH22、CH23
左PMC	5	CH28、CH29、CH33、CH34、CH35
右PMC	5	CH1、CH15、CH18、CH30、CH31
左SMC	3	CH13、CH14、CH32
右SMC	3	CH2、CH16、CH17

ROI	电-云组(n = 11)	云-电组(n = 11)	同步组(n = 11)	χ²值	P值	P值^a	P值^b	P值^c
左PFC	0.006±0.054	0.035±0.043	-0.001±0.058	21.475	< 0.001	0.026	0.140	< 0.001
右PFC	0.013±0.048	0.043±0.044	-0.002±0.049	36.873	< 0.001	0.004	0.014	< 0.001
左SMC	0.032±0.057	0.068±0.049	0.035±0.043	11.697	0.003	0.006	1.000	0.014
右SMC	0.013±0.047	0.047±0.051	0.028±0.032	4.424	0.109
左PMC	0.042±0.051	0.076±0.054	0.055±0.048	17.782	< 0.001	< 0.001	1.000	0.005
右PMC	0.029±0.052	0.053±0.063	0.031±0.035	9.855	0.007	0.023	1.000	0.017

不同时序经颅直流电刺激结合坐位太极拳云手对健康青年人脑皮质激活的功能性近红外光谱研究

Effect of transcranial direct current stimulation combined with seated Taijiquan Yunshou in different sequences on cerebral cortical activation for healthy youths: a functional near-infrared spectroscopy study

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[15]	陈园月, 李加斌, 蒯凤, 彭丽丽, 项洁. 多通道功能性电刺激结合任务导向训练对脑卒中上肢偏瘫患者脑功能网络的即刻影响[J]. 《中国康复理论与实践》, 2024, 30(4): 462-467.