《中国康复理论与实践》

《中国康复理论与实践》 ›› 1995, Vol. 1 ›› Issue (01): 28-31.

• 理论与实践 • 上一篇    下一篇

截瘫与正常鼠体内头孢唑啉药物动力学的实验研究

刘青1; 金学源1; 马岳珠1; 刘丽2   

  1. 1.中国康复研究中心; 2.长春市第二人民医院
  • 收稿日期:1995-10-18 出版日期:1995-12-25 发布日期:1995-12-25

A Experimental Study on Pharmacokinetics of Cefazolinum in Rats with Paraplegia

Liu Qing,Jin Xueyuan,Ma Yuezhu,et al   

  1. Chinese Journal of Rehabilitation Theory & Practice.-1995,1(1)-28～31
  • Received:1995-10-18 Published:1995-12-25 Online:1995-12-25

PDF (PC)

摘要： 本实验将20只雄性Wiｓtａｒ大白鼠分为实验和对照两组，实验组制备成急性截瘫模型，两组分别经尾静脉单剂量注射头孢唑啉250ｍｇ，按时采尾静脉血标本。用高压液相法（ＨPＬＣ）测定血浆中药物浓度。结果，分布相和消除相药物浓度截瘫组均大于正常组，药代动力学参数表示截瘫组中央和周边室的表观分布容积减少，T1/2β延长，使分布和消除相血药浓度增加。本文提示：临床上截瘫患者的用药需注意监测血药浓度，尤其对伴有肝肾功能障碍的患者以及应用安全范围较窄的药物时更应慎重。

关键词: 药代动力学, 截瘫

Abstract: Wistar male rats were divided into two grorps, The experimental group was madethe paraplegia model. BOth groups were received cefazolinum 250 mg through single-dosed intra-venous injection. The concentration was measured by HPLC. The result implied that a).the concentra-tion of cefazolinum in paraplegic group was higher than that in control group either the distributingphase or the eliminating phase(p<0. 001);b). the pharmacokinetic parameters showed that the apparent vlumeof distribution:(v1,v2)was decreased and the elimination. half-life(t1/2β)was more length-y in paraplegia group. So that the drug concentration increased. The conclusion is that the dosege on thepatients with paraplegia should be clinically monitored,especilly following hepatic and renal disfunctionand with the drugs with narrowed safety range.

Key words: pharmacokinetics, paraplegia