《中国康复理论与实践》

《中国康复理论与实践》 ›› 2001, Vol. 7 ›› Issue (03): 118-119.

• 论著 • 上一篇    下一篇

胆红素脑病仔兔脑组织氨基酸含量的研究

李林; 李晓捷; 姜志梅; 吕杰   

  1. 黑龙江省小儿脑性瘫痪防治疗育中心 黑龙江佳木斯市 154003
  • 收稿日期:2001-04-19 出版日期:2001-09-25 发布日期:2001-09-25

Study on change of aminoacid content in the brain of newborn rabbits with bilirubin encephalopathy

LI Lin,LI Xiao-jie,JIANG Zhi-mei,et al   

  1. Prevention, Treatment and Rehabilitation Center for Child Cerebral Palsy in Heilongjiang Province, Jiamusi 154003, China
  • Received:2001-04-19 Published:2001-09-25 Online:2001-09-25

PDF (PC)

被引次数

6

摘要： 目的探讨胆红素脑病仔兔脑组织中氨基酸含量的变化。方法采用生后 3—5天纯系仔兔腹腔注射胆红素200mg/kg方法制备胆红素脑病动物模型,应用日立 835-50型氨基酸分析仪检测脑组织的氨基酸含量。结果胆红素脑病脑组织中谷氨酸、门冬氨酸含量下降;γ-氨基丁酸、丙氨酸、酪氨酸、缬氨酸、苯丙氨酸升高。结论脑组织中递质性氨基酸含量的变化提示兴奋性氨基酸的兴奋性毒性作用可能导致仔兔胆红素脑病的发生;非递质性氨基酸水平的升高证实了胆红素可抑制脑组织蛋白质的生物合成。

关键词: 胆红素脑病, 递质性氨基酸, 非递质性氨基酸

Abstract: ObjectiveTo study change of aminoacid content in the brain of newborn rabbits with bilirubin encephalopathy. MethodsNewborn rabbits (3-5 days after birth) with bilirubin encephalopathy were induced by administration intra peritoneally with bilirubin (200mg/kg). Aminoacid content in brain were analysed by Hitachi 835 50 type aminoacid analysis instrument.ResultsThe content of glutamate and aspartate in brain tissue with bilirubin encephopathy decrease; GABA, alanine, tyrosine, valine and pheny lalanine increase. ConclusionsThe change of content of neurotransmitters in brain indicates that excitotoxicity of EAAs may contribute to the bilirubin encephalopathy. The increase of non neurotransmitters level proves that bilirubin may inhibit the biologic composition of protein in brain.

Key words: bilirubin encephalopathy, neurotransmitter, non neurotransmitter