《中国康复理论与实践》

《中国康复理论与实践》 ›› 2002, Vol. 8 ›› Issue (01): 3-4.

• 专题研究 • 上一篇    下一篇

血小板源生长因子及其受体在烧伤肉芽组织和增生性瘢痕中的表达

贲晓松; 利天增; 祁少海; 梁惠珍; 文剑明; 黎志明; 罗超权   

  1. 中山医科大学附属一院烧伤胸外科 广东广州市 510089
  • 收稿日期:2001-08-06 出版日期:2002-01-25 发布日期:2002-01-25

Study of expression of platelet-derived growth factor and its receptor in granulation tissue of burn wound and post-burn hypertrophic scar at excessive stages

BEN Xiao-song, LI Tian-zeng, QI Shao-hai, et al   

  1. Department ofBurn, First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, Guangdong, China
  • Received:2001-08-06 Published:2002-01-25 Online:2002-01-25

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摘要： 目的探讨血小板源生长因子(PDGF)及其受体在瘢痕增生过程中的作用。方法采用多克隆抗体并以免疫组织化学方法检测9例正常真皮、7例肉芽组织及34例增生性瘢痕标本中的PDGF及其受体和Ⅰ型胶原的表达情况。结果PDGF及其受体在肉芽组织和增生性瘢痕中的表达明显增强,在6个月以内的增生性瘢痕中达到高峰,此后逐渐减弱;而正常真皮组织中仅少数标本呈微弱表达(P<0.05)。结论PDGF及其受体表达的增强可能与瘢痕的增生密切相关。

关键词: 烧伤, 瘢痕, 增生性瘢痕, 血小板源生长因子

Abstract: ObjectiveTo investigate the role of platelet-derived growth factor(PDGF) and its receptor in the development of hypertrophic scar. MethodsThe expression of PDGF and its receptor were detected in biopsy specimens of 9 pieces of normal skin, 7 pieces of granulation tissue of burn wound and 34 pieces of hypertrophic scar by immunohistochemical staining using specific polyclonal antibodies.ResultsPDGF and its receptor markedly increased in granulation tissue and hypertrophic scars, reaching the peak in the hypertrophic scars within 6 months and then decreased after the peak, whereas PDGF and its receptor expressed weakly in only a few normal skin specimens, and the differences were significant(P<0.05).ConclusionsThe increasing expression of PDGF and its receptor may be related to the development of hypertrophic scar.

Key words: burn, scar, hypertrophic scar, platelet-derived growth factor(PDGF)