《中国康复理论与实践》

《中国康复理论与实践》 ›› 2002, Vol. 8 ›› Issue (07): 415-417.

• 基础研究 • 上一篇    下一篇

大脑中动脉缺血对脑表面血管密度的影响

廖维靖1;杨万同1;黄一茜2;刘淑红3;马子敏3;范明3   

  1. 1.武汉大学中南医院康复医学科 湖北武汉市 430071;2.河北省保定市第一中心医院 河北保定市 071000;3.军事医学科学院基础医学研究所 北京市 100850
  • 收稿日期:2002-05-16 出版日期:2002-07-25 发布日期:2002-07-25

The effects of the middle cerebral artery occlusion on the density of the brain surface vessels in the rat

LIAO Wei-jing,YANG Wan-tong,HUANG Yi-qian,et al   

  1. Department of Rehabilitation Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China
  • Received:2002-05-16 Published:2002-07-25 Online:2002-07-25

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摘要： 目的研究大脑中动脉缺血性损伤对脑表面血管密度变化的影响。方法雄性Wistar大鼠41只,随机分为空白对照组(n=3)、假手术组(n=3)、缺血损伤再灌注组(n=35)。采用线栓模型造成右大脑中动脉血供阻断2h,缺血损伤再灌注组的再灌注时间点为1d、2d、3d、7d和14d。测定局部脑血流量,观察大脑表面的血管形态,测定右大脑半球单位面积的血管数目和总长度。结果随再灌注时间延长,右侧半球的血管数目、长度显著增加。结论缺血损伤诱导血管新生。

关键词: 缺血性脑损伤, 大脑中动脉, 大鼠

Abstract: ObjectiveTo investigate the effects of the middle cerebral artery occlusion on the density of the brain surface vessels in the rat.MethodsForty one male Wistar rats with an average body weight of 170±10g were randomly divided into three groups: group A(n=3) underwent no operation, group B(n=3) underwent sham operation, group C(n=35) underwent an operation of ischemic brain injury. The right middle cerebral artery occlusion (MCAO) of group C rats were induced by 5/0 monofilament nylon suture for 2 hours. The time points of reperfusion was 1 day, 2 days, 3 days, 7 days and 14 days following MCAO. The regional cerebral blood flow in the right brain, the morphology, number, length of the right hemisphere surface vessels were measured. ResultsThe number, length of the right hemisphere vessels increased with the progress of reperfusion time. Conclusions The ischemia induced the production of vessels in the brain in the rats.

Key words: ischemic brain injury, middle cerebral artery, rat