《中国康复理论与实践》

《中国康复理论与实践》 ›› 2003, Vol. 9 ›› Issue (04): 250-251.

• 临床康复 • 上一篇    下一篇

内皮素与P-选择素在冠心病中的意义

欧阳桂芳1; 陈晓敏2   

  1. 1.浙江省宁波市第一医院血液科 浙江宁波市 315010;2.浙江省宁波市第二医院心血管内科 浙江宁波市 315010
  • 收稿日期:2003-03-18 出版日期:2003-04-25 发布日期:2003-04-25

Clinical significance of endothelin-1 and P-selection in coronary heart disease

OUYANG Gui-fang,CHEN Xiao-min   

  1. Department of Haemotology, No1Hospital Ningbo,315010, Zhejiang,China
  • Received:2003-03-18 Published:2003-04-25 Online:2003-04-25

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被引次数

6

摘要： 目的研究内皮素(endothelin-1,ET-1)、P-选择素和肌钙蛋白I(CTnI)在急性心肌梗死(acute myocardialinfarction ,AMI)和不稳定性心绞痛(unstableangina ,UA)中的意义。 方法用放射免疫法测定ET-1,流式细胞仪测定P-选择素,Access化学发光法测定CTnI,共检测23例AMI患者,21例UA患者及28例健康对照者。结果AMI组的ET-1、P-选择素和CTnI值均明显高于对照组(P<0.05—0.01);UA组的ET-1、P-选择素高于对照组(P<0.05);UA组的CTnI与对照组无显著性差异(P>0.05);UA组的P-选择素、CTnI低于AMI组(P<0.05)。多元回归分析发现P-选择素与CTnI相关,相关系数r=0.404,(P<0.01)。结论ET-1、P-选择素是检测血栓前状态的敏感指标。

关键词: 心肌梗死, 不稳定性心绞痛, 内皮素, P-选择素, 肌钙蛋白I

Abstract: ObjectiveTo explored the relationship among endothelin-1(ET-1), P-selection and troponin I(CTnI) in acute myocardial infarction (AMI) and unstable angina (UA).MethodsPlasma level of endothelin-1 was analyzed by radioimmunoassay, the expression of P-selection was analyzed by flow cytometery technique and troponin I was analyzed by paramagnetic partile chemiluminescent immunoassay in 23 AMI cases, 21 UA cases and 28 healthy controls.ResultsPlasma levels of ET-1 and CTnI in AMI patients were higher than in controls(P<0.05). The expression of P-selection in AMI patients was higher than in controls (P<0.01).Plasma levels of ET-1 and expression of P-selection in UA patients were higher than in controls (P<0.05). There was an increased trend of CTnI in UA patients in contrast to controls, but without statistical significance(P>0.05).As compared with UA, plasma levels of CTnI and expression of P-selection were elevated in AMI patients (P<0.05). No significant difference was observed between AMI and UA cases in plasma level of ET-1. Multivariate regression analysis revealed that P-selection was significantly associated with AMI and UA cases compared with plasma level of CTnI (r=0.404,P<0.01).ConclusionsPlasma levels of ET-1 and P-selection were sensitive markers as prethrombolic status.

Key words: acute myocardial infarction(AMI), unstable angina(UA), endothelin-1(ET-1), P-selsction, troponin I(CTnI)