《中国康复理论与实践》

《中国康复理论与实践》 ›› 2003, Vol. 9 ›› Issue (06): 344-345.

• 基础研究 • 上一篇    下一篇

食管癌中ICE、Fas、FasL的表达及其意义

张红; 晏梅; 文小岗; 高冬玲; 牛韵韵; 张云汉   

  1. 郑州大学第一附属医院病理科,郑州大学医学院病理教研室,河南省肿瘤病理重点实验室 河南郑州市 450052
  • 收稿日期:2003-03-05 出版日期:2003-06-25 发布日期:2003-06-25

Expression and significance of the ICE, Fas and FasL protein in the esophageal carcinoma

ZHANG Hong,YAN Mei,WEN Xiao-gang,et al   

  1. Department of Pathology,The First Affiliated Hospital of Henan Medical University,Henan Key Laboratory of Tumor Pathology,Zhengzhou 450052,Henan,China
  • Received:2003-03-05 Published:2003-06-25 Online:2003-06-25

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摘要： 目的了解食管癌组织中的促凋亡状况及其与抗肿瘤免疫的关系。方法采用免疫组化LSAB法对46例食管癌手术切除标本中的白细胞介素1β转化酶(IL-1β converting enzyme,ICE)、Fas、FasL蛋白进行标记,并对其中13例进行TdT介导dUTP缺口末端标记。结果ICE、Fas、FasL蛋白在癌巢中的阳性率分别为78.26%、60.87%和47.83%,ICE蛋白的表达程度与癌组织学分级有相关性。结论癌组织表达Fas、FasL,可能参与癌细胞的免疫逃避;ICE的表达与癌组织分化有一定关系。

关键词: 凋亡, 食管癌, 凋亡相关蛋白

Abstract: ObjectiveTo study the relationship between the antitumor immunoreaction and the cell apoptosis in esophageal carcinoma.MethodsThe IL-1β converting enzyme, Fas and FasL protein were labeled by LSAB immunohistochemistric method in 46 cases of esophageal carcinoma, of which 13 cases were labeled by TdT mediated dUTP nick end labeling (TUNEL).ResultsThe positive rates of ICE, Fas and FasL proteins in the cancer nests were 78.26%, 60.87% and 47.83%. The expression of ICE protein was related to the histological grading of the cancer.Conclusions The expression of Fas, FasL protein may be related to the immunological escape of the cancer cell; the expression of ICE was related to the histological grading of the cancer.

Key words: apoptosis, esophageal carcinoma, apoptosis related protein