《中国康复理论与实践》

《中国康复理论与实践》 ›› 2003, Vol. 9 ›› Issue (07): 399-400.

• 专题研究 • 上一篇    下一篇

神经干细胞移植对帕金森病模型小鼠行为的影响

郭安臣; 李学坤; 澹台冀澄; 孔令娜; 左萍萍   

  1. 中国医学科学院、中国协和医科大学基础医学院药理系 北京市 100005
  • 收稿日期:2003-06-30 出版日期:2003-07-25 发布日期:2003-07-25

Effects of neural stem cells transplantation on the behavior of Parkinson's disease mice

GUO An-chen,LI Xue-kun,TANTAI Ji-cheng,et al   

  1. Department of Pharmacology,PUMC&CAMS,Beijing 100005,China
  • Received:2003-06-30 Published:2003-07-25 Online:2003-07-25

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摘要： 目的评价神经干细胞移植对帕金森病(PD)模型小鼠行为缺陷的改善作用。方法采用自发运动、Morris水迷宫和转杆实验对小鼠的行为进行评价。结果与对照组相比,PD模型小鼠的自发运动次数明显减少,水迷宫寻台潜伏期延长,转杆时间缩短。经单侧和双侧纹状体神经干细胞移植后2周、4周和8周,PD模型小鼠的自发运动次数明显增加,水迷宫寻台时间显著缩短,转杆时间延长。结论神经干细胞移植能够有效改善PD模型小鼠的行为缺陷。

关键词: 神经干细胞移植, 帕金森病模型, 行为, 小鼠

Abstract: ObjectiveTo observe the effects of neural stem cells transplantation on the behavioral deficits of Parkinson's disease mice.MethodsSpontaneous movement,Morris Water Maze and Rotarod were adopted to evaluate the behavioral changes.ResultsCompared with the control,the time of spontaneous movement was decreased,the latency of Water Maze was lengthened,and the time of Rotarod was shortened in the Parkinson's disease(PD) mice. These deficits were improved 2,4 and 8 weeks after unilateral and bilateral transplantation of neural stem cells.ConclusionsThe transplantation of neural stem cells can improve the behavioral deficits in the PD mice.

Key words: neural stem cells transplantation, Parkinson's disease, behavior, mice