《中国康复理论与实践》

《中国康复理论与实践》 ›› 2003, Vol. 9 ›› Issue (10): 596-598.

• 基础研究 • 上一篇    下一篇

中药脑复聪对缺血性痴呆小鼠脑内NMDA受体的影响

徐慧媛1; 张孟仁1; 郭赛珊1; 左萍萍2   

  1. 1.中国医学科学院、中国协和医科大学北京协和医院中医科 北京市 100730;2.中国医学科学院、中国协和医科大学基础医学院药理系
  • 收稿日期:2003-08-14 出版日期:2003-10-25 发布日期:2003-10-25

Effects of Naofucong grain on brain NMDA receptor in experimental dementia mice

XU Hui-yuan, ZHANG Meng-ren, GUO Sai-shan,et al   

  1. Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2003-08-14 Published:2003-10-25 Online:2003-10-25

PDF (PC)

被引次数

39

摘要： 目的观察中药脑复聪对脑缺血小鼠学习记忆的影响,探讨其作用机理。方法采用脑缺血再灌注法建立痴呆小鼠模型。给予实验动物中药脑复聪灌胃,并以当归芍药散作对照,观察脑复聪对脑缺血再灌注小鼠学习记忆障碍的作用和对脑兴奋性氨基酸NMDA受体的影响。结果脑复聪治疗组动物的水迷宫潜伏期明显短于缺血模型组(P<0.01),大脑皮层与海马NMDA受体基本接近正常组,但明显低于模型组(P<0.01)。结论脑复聪对脑缺血小鼠学习记忆的改善作用与其抑制NMDA受体活性有关。

关键词: 脑复聪, 中药, 缺血再灌注损伤, N-甲基-D-天门冬氨酸受体

Abstract: ObjectiveTo observe effects of Naofucong grain on learning and memory in cerebral ischemic mice, and identify the mechanisms on N-methyl-D-aspartate (NMDA) receptor.MethodsExperimental dementia mice were induced by ischemia reperfusion injury, and treated with Naofucong grain or Dangguishaoyao powder (positive control medicine). Learning and memory were tested in the Morris water maze. Activities of NMDA receptor in brain cortex and hippocampus were detected ResultsIncubation periods of mice treated with Naofucong grain were significantly shorter than that of ischemic model mice (P<0.01) Activities of NMDA receptor in brain cortex and hippocampus showed no difference between Naofucong grain treated mice and normal mice (P>0.05)Activities of NMDA receptor in brain cortex and hippocampus in Naofucong grain treated mice were significantly lower than that in ischemic model mice(P<0.01) ConclusionThe improvement of Naofucong grain in the memory and learning in cerebral ischemic mice may be related to the inhibition of the activity of NMDA receptor.

Key words: Naofucong, traditional Chinese medicine, ischemia and reperfusion injury, N-methyl-D-aspartate receptor