《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (01): 25-27.

• 基础研究 • 上一篇    下一篇

迷走神经刺激对致痫动物的抗痫作用及其机理研究

赵兰峰; 李菁锦; 安仰原; 王毅珍   

  1. 1.首都医科大学神经生物学系 北京市 100054;2.北京天坛医院神经内科 北京市 100050
  • 收稿日期:2003-10-04 出版日期:2004-01-25 发布日期:2004-01-25

Effect and mechanism of vagus nerve stimulation on seizure in animal with epilepsy

ZHAO Lan-feng, LI Jing-jin, AN Yang-yuan, et al   

  1. Department of Neurobiology, Capital University of Medical Sciences,Beijing 100054, China
  • Received:2003-10-04 Published:2004-01-25 Online:2004-01-25

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摘要： 目的研究迷走神经刺激(VNS)对致痫动物的抗痫作用及机理。方法分别用青霉素、海人藻酸(KA)、士的宁对34只大鼠和8只家兔致痫,以动物大脑皮层电图(ECoG)、海马神经元电活动及行为学表现为观测指标,观察间断性左侧VNS对致痫动物痫性发作的影响。结果VNS可以阻抑致痫动物的痫性发作,对痫性ECoG、海马神经元电活动及行为学表现均呈现有显著的抑制。结论内脏传入信息可能通过大脑皮层、海马部位的整合作用达到有效阻抑躯体痫性活动。

关键词: 癫痫, 发作, 迷走神经, 刺激

Abstract: ObjectiveTo study the effect and mechanism of vagus nerve stimulation(VNS) on seizure in animal with epilepsy.MethodsSeizures of 34 rats and 8 rabbits were induced by Penicillin, Kainic acid(KA) and Strychnice respectively. Electrocorticographic(ECoG), electrical activition of hippocampal neurons and behaviour were observed to evidence the effects of left intermittent VNS .ResultsVNS could suppress seizures in animal models with epilepsy. There were significant changes in epileptiform ECoG, discharges of hippcampal neuron and behaviour. ConclusionSomatic seizure can be effectively inhibited by visceral afferent inputs through integration in cortical and hippocampal parts.

Key words: epilepsy, seizure, vagus nerve, stimulation