《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (03): 183-184.

• 临床研究 • 上一篇    下一篇

脑卒中与血同型半胱氨酸水平的关系

周炯1; 张松照2; 章昀1; 陈忠3; 丁美萍1   

  1. 1.浙江大学医学院附属二院神经内科 浙江杭州市 310009;2.浙江大学附属二院生化室 浙江杭州市 310009;3.浙江大学医学院药理教研室 浙江杭州市 310009
  • 收稿日期:2004-02-12 出版日期:2004-03-25 发布日期:2004-03-25

Relationship between the homocysteine level and stroke

ZHOU Jiong, ZHANG Song-zhao,ZHANG Yun, et al   

  1. Department of Neurology, Second Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang, China
  • Received:2004-02-12 Published:2004-03-25 Online:2004-03-25

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摘要： 目的探讨脑卒中与同型半胱氨酸(Hcy)的关系。方法选取脑卒中患者57例,其中脑出血(CH)组21例,脑梗死(CI组)36例,另选正常对照28例,分别测定血浆Hcy、VitB12 、叶酸、肌酐浓度,对所有患者进行临床神经功能缺损指数(CNDS)评定,并测定CH组的血肿体积(HV)。结果CI组和CH组的Hcy水平均比对照组高(P<0.05或P<0.01) ,而CI组和CH组之间比较无显著性差异。CI组和CH组Hcy与叶酸水平呈高度显著负相关性(r=-0.442,P=0.007)或显著负相关(r=-0.531,P=0.013),均与VitB12水平无显著相关性。结论高Hcy血症与脑卒中关系密切;血浆Hcy水平与叶酸水平呈负相关,与VitB12相关不显著。

关键词: 同型半胱氨酸, 脑梗死, 脑出血, 临床神经功能缺损指数, 血肿体积

Abstract: ObjectiveTo study the relationship between the homocysteine (Hcy) level and stroke. Methods57 cases, including cerebral haemorrhage (CH, 21 cases) and cerebral infarction (CI, 36 cases) , and 28 healthy cases as control group were selected to measure their level of Hcy, VitB12 , folic acid and creatinine(Cr). At the same time, the clinical neurological disfunction scale(CNDS) of all patients was evaluated and the hematom volume (HV) of the CH group was assayed. ResultsThe Hcy level of both CI and CH group was significantly higher than that of the control group(P<0.05 or P<0.01). No significant difference was found between CI and CH group on Hcy level. The Hcy level showed a very strong or strong reverse association with folic acid level in the CI and CH group (r=-0.442,P=0.007 or r=-0.531,P=0.013), but no significant correlation with VitB12 level. No correlation was found between Hcy level and CNDS in both the CI and CH group, either no correlation between Hcy level and HV in the CH group. ConclusionThere is a close relationship between hyperhomocysteine and stroke. Hcy level is reversely associated with folic acid level but not correlated with VitB12 level.

Key words: homocysteine(Hcy), cerebral infarction(CI), cerebral haemorrhage(CH), clinical neurological disfunction scale(CNDS), hematom volume(HV)