《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (08): 477-478.

• 基础研究 • 上一篇    下一篇

雌激素替代疗法对去卵巢大鼠呼吸的影响

王凤斌1; 王鲁娟2; 李宁1; 程秀臻1   

  1. 1.潍坊医学院生理教研室 山东潍坊市 261042;2.潍坊医学院诊断学教研室 山东潍坊市 261042
  • 收稿日期:2004-04-26 出版日期:2004-08-25 发布日期:2004-08-25

Effect of estrogen replacement therapy on respiratory of ovariectomized rats

WANG Feng-bin, WANG Lu-juan, LINing, et al   

  1. Department of Physiology, Weifang Medical College, Weifang 261042, Shandong, China
  • Received:2004-04-26 Published:2004-08-25 Online:2004-08-25

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摘要： 目的观察雌二醇对去卵巢大鼠呼吸的影响。方法30只雌性成年SD大鼠随机分为去卵巢组(A组)、雌二醇组(B组)和假手术组(C组),双侧卵巢切除术后10天起,A组大鼠皮下注射17β雌二醇(20μg/kg/d),B组和C组大鼠仅注射生理盐水,连续用药6周后,通过检测血清雌二醇水平和引导膈神经放电,评定雌激素对大鼠呼吸的影响。结果A组大鼠血清雌二醇浓度明显低于B组和C组(P<0.01),B组与C组之间无显著性差异;A组大鼠的膈神经放电频率和积分幅度低于B组和C组(P<0.05),B组与C组之间无显著性差异。结论雌二醇对去卵巢大鼠的呼吸有兴奋作用。

关键词: 雌二醇, 呼吸, 去卵巢, 大鼠

Abstract: ObjectiveTo observe effect of estradiol on respiratory of ovariectomized rats.Methods30 adult female rats were randomly divided into ovariectomy group (group A), estradiol group (group B) and sham ovariectomy group (group C). Rats of group B were injected with 17-β estradiol (20μg/kg/d), that of group A and group C were injected only with normal saline (0.1ml/d). After 6 weeks, effect of estradiol on respiratory of ovariectomized rats was assessed with testing level of rats' serum estradiol and discharge frequency and integrated amplitude of phrenic nerve. ResultsThe level of serum estradiol of group A was significantly decreased compared with group B and group C (P<0.01). Discharge frequency and integrated amplitude of phrenic nerve of group A were decreased compared with group B and group C (P<0.05).ConclusionEstradiol can excite respiratory responses in ovariectomized rats.

Key words: estradiol, respiration, ovariectomy, rat