《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (09): 513-514.

• 专题 •    下一篇

久强脑立清对自发性高血压大鼠重要器官的保护作用

左萍萍1; 赵现红2; 徐海峰1; 张卿1; 杨楠1; 孔祥英1; 刘红菊1   

  1. 1.中国医学科学院、中国协和医科大学基础医学院 北京市 100005;2.北京同仁堂股份有限公司科学研究所 北京市 100011
  • 收稿日期:2004-09-05 出版日期:2004-09-25 发布日期:2004-09-25

Jiuqiang Naoliqing affords protection to vital organs of spontaneous hypertension rats

ZUO Ping-ping, ZHAO Xian-hong, XU Hai-feng, et al   

  1. Department of Pharmacology, School of Basic Medicine, Peking Union Medical College & Chinese Academyof Medical Sciences, Beijing 100005, China
  • Received:2004-09-05 Published:2004-09-25 Online:2004-09-25

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摘要： 目的探讨久强脑立清(JNQ)对自发性高血压大鼠(SHR)重要器官心、脑、肾组织形态学的影响。方法动物分为4组,Wistar大鼠对照组、SHR组、SHR服用JNQ高剂量组(0.530g/kg)和低剂量组(0.265g/kg),给药5周。采用尾脉搏测压法测定动物血压;动物经组织灌流后,低温下快速取出心、脑、肾,固定于10%福尔马林中,4℃保存,常规组织切片,HE染色。结果给药前各组SHR的血压明显高于对照组(P<0.01),给药3周和5周后血压未见明显下降。组织病理结果显示,未治疗组SHR心肌细胞肥大,肌束间小动脉壁增厚,官腔变窄;大脑皮层血管管腔狭窄,管壁增厚,血管周围间隙增大;肾小球萎缩,有玻璃样变。上述病理性改变在经JNQ治疗5周后得到不同程度的改善,以高剂量组明显。结论SHR经JNQ治疗5周后血压未见明显降低,但对重要器官心、脑、肾的病变有较明显改善作用。

关键词: 久强脑立清, 自发性高血压大鼠(SHR), 心, 脑, 肾, 病理

Abstract: ObjectiveTo investigate the Jiuqiang Naoliqing's (JNQ) histological influence on hearts, brains and kidneys of spontaneous hypertension rats (SHR). MethodsThe rats were randomly divided into four groups: Wistar control group, SHR group, higher dose JNQ treated SHR group(0.530 g/kg) and lower dose JNQ treated SHR group(0.265 g/kg). The treatment lasted five weeks, and the rats' blood pressure were monitored through tail pulse. After the perfusion procedure, rats' hearts, brains and kidneys were rapidly removed in low temperature condition and stored in 10% formalin solution of 4 ℃.Then routine sections were obtained and the slides were stained with HE.ResultsBefore treatment, the blood pressure of SHR groups were distinctly higher than that of the control group(P<0.01), nevertheless, no obvious blood pressure downgrade were observed after three week and five week treatment. Histopathologic study showed: in SHR group,heart with hypertrophic cardiac muscle, proliferative arterial wall and strictured lumina; Cortex with angiostenosis, proliferative vascular wall and large perivascular space; Glomerulus atrophy with hyaline degeneration. These pathologic changes got respective alleviation after five week treatment of JNQ, particularly in higher dose group.ConclusionSHR who got five week treatment of JNQ didn't gain obvious blood pressure downgrade. But the treatment did good to their vital organs and can obviously alleviate hearts, brains and kidneys' pathologic changes.

Key words: Jiuqiang Naoliqing, spontaneous hypertension rats (SHR), heart, brain, kidney, pathology