《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (09): 518-519.

• 专题 • 上一篇    下一篇

久强脑立清对自发性高血压大鼠血浆血栓素A2和前列环素水平的影响

孔祥英1; 左萍萍1; 李志猛2; 段金虹1; 孔令娜1; 戴顺龄1   

  1. 1.中国医学科学院、中国协和医科大学基础医学院药理系 北京市 100005;2.北京同仁堂股份有限公司科学研究所 北京市 100011
  • 收稿日期:2004-07-29 出版日期:2004-09-25 发布日期:2004-09-25

Effect of Jiuqiang Naoliqing on the TXA_2 and PGI_2 level in spontaneous hypertension rat plasma

KONG Xiang-ying,ZUO Ping-ping,LI Zhi-meng, et al   

  1. Department of Pharmacology,School of Basic Medicine,Peking Union Medical College & Chinese Academyof Medical Sciences,Beijing 100005,China
  • Received:2004-07-29 Published:2004-09-25 Online:2004-09-25

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摘要： 目的探讨久强脑立清(JNQ)对自发性高血压大鼠(SHR)血浆血栓素A2(TXA2)和前列环素(PGI2)水平的影响。方法设立JNQ低、中、高剂量3个组,剂量分别为0.133g/kg、0.265g/kg和0.530g/kg,SHR和正常Wistar大鼠对照组给予1%羧甲基纤维素溶媒对照,分别灌胃给药5周后,分离血浆,用放免法测定血浆中TXA2和PGI2的稳定代谢产物TXB2和6 keto PGF1α的水平。结果SHR血浆TXB2及TXB2/6 keto PGF1α(T/P)值明显上升(P<0.01),PGI2无明显变化(P>0.05)。经JNQ3种剂量治疗5周后,SHR的血浆TXB2均显著下降,并呈明显的剂量依赖关系,高剂量组SHR血浆6 keto PGF1α水平也有明显提高,各治疗组T/P比值均下降。结论JNQ对SHR血浆TXA2/PGI2的平衡失调有明显的改善作用。

关键词: 久强脑立清, 自发性高血压大鼠(SHR), 血栓素A2, 前列环素

Abstract: ObjectiveTo investigate the effect of Jiuqiang Naoliqing(JNQ) on the TXA2 and PGI2 level in spontaneous hypertension rat (SHR) plasma.MethodsThe plasma was separated after the SHR and Wistar rats were treated with JNQ at the dose of 0.133g/kg,0.265g/kg,0.530g/kg and 1% carboxymethyl cellulose respectively for 5 weeks. The level of TXB2 and 6 keto PGF1α ,stable metabolin of TXA2 and PGI 2,in SHR plasma was tested by radioimmunoassay.ResultsThe level of TXB2 and the ratio of TXB2/6 keto PGF1α (T/P) in SHR plasma increased significantly(P<0.01),and there was no significant difference in the concentration of 6 keto PGF1α between Wistar rats and SHR plasma(P>0.05). JNQ could increase the generation of 6 keto PGF1α and decrease the level of TXB2 and T/P in SHR plasma after treated with different dosages for 5 weeks.ConclusionJNQ may improve the balance between TXA2 and PGI2 in SHR plasma.

Key words: Jiuqiang Naoliqing, spontaneous hypertension rat(SHR), thromboxane A2(TXA2), prostaglandin I2(PGI2)