《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (09): 520-521.

• 专题 • 上一篇    下一篇

久强脑立清促进自发性高血压大鼠脑内降钙素基因相关肽和突触素Ⅰ的表达

张卿1; 左萍萍1; 赵现红2; 孔祥英1; 孔令娜1; 牟亮1   

  1. 1.中国医学科学院、中国协和医科大学基础医学院 北京市 100005;2.北京同仁堂股份有限公司科学研究所 北京市 100011
  • 收稿日期:2004-07-29 出版日期:2004-09-25 发布日期:2004-09-25

Jiuqiang Naoliqing enhancing the expression of CGRP and Synapsin Ⅰ in brain of spontaneous hypertension rats

ZHANG Qing, ZUO Ping-ping,ZHAO Xian-hong, et al   

  1. Department of Pharmacology, School of Basic Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100005, China
  • Received:2004-07-29 Published:2004-09-25 Online:2004-09-25

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被引次数

6

摘要： 目的研究久强脑立清(JNQ)对自发性高血压大鼠(SHR)脑内降钙素基因相关肽(CGRP)和突触素Ⅰ表达的影响。方法大鼠随机分为4组:Wistar组、SHR组、JNQ低剂量SHR组、JNQ高剂量SHR组。给药3周后,用免疫组织化学的方法检测CGRP和突触素Ⅰ在海马齿状回、CA1区和大脑皮层的表达变化。结果与Wistar组比较,SHR组CGRP和突触素Ⅰ在海马齿状回、CA1区和大脑皮层的表达均降低,给予低剂量JNQ后能够增加CGRP在大脑皮层的表达,高剂量JNQ既能够增加CGRP在海马齿状回、CA1区和皮层的表达,还能增加突触素Ⅰ在海马CA1区的表达。结论JNQ可能通过上调CGRP的表达来改善SHR脑内的微循环,通过上调突触素Ⅰ的表达来增强SHR中枢神经系统的调控功能。

关键词: 自发性高血压, 久强脑立清, 降钙素基因相关肽(CGRP), 突触素Ⅰ

Abstract: ObjectiveTo study the influence of Jiuqiang Naoliqing (JNQ) on the expression of calcitonin gene related peptide(CGRP)and Synapsin Ⅰ in brain of the spontaneous hypertension rats (SHR). MethodsThe rats were randomly divided into 4 groups: Wistar group, SHR group, lower dose of JNQ treated SHR group and higher dose of JNQ treated SHR group. The expression of CGRP and Synapsin Ⅰ in the dentate gyrus, CA1 subfield of hippocampus and cortex were determined by immunohistochemistry after treatment for 3 weeks. ResultsCompared with the Wistar group, the expression of CGRP and Synapsin Ⅰ in the dentate gyrus, CA1 subfield of hippocampus and cortex of SHR group significantly decreased. The treatment with lower dose of JNQ significantly enhanced the expression of CGRP in cortex(P<0.05 vs SHR).The treatment with higher dose of JNQ significantly enhanced not only the expression of CGRP in the dentate gyrus, CA1 subfield of hippocampus and cortex, but also that of Synapsin Ⅰ in the CA1 subfield of hippocampus selectively in comparison with SHR group. ConclusionJNQ may improve the micro circulation in brain by up regulating the expression of CGRP and enhance the modulating function of central nervous system by up regulating the expression of Synapsin Ⅰ in spontaneous hypertension rats.

Key words: spontaneous hypertension rats, Jiuqiang Naoliqing, calcitonin gene related peptide (CGRP), Synapsin Ⅰ