《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (09): 524-525.

• 专题 • 上一篇    下一篇

久强脑立清对昆明种小鼠行为的影响

徐海峰1; 李志猛2; 杨楠1; 左萍萍1; 岳赟1; 牟亮1   

  1. 1.中国医学科学院、中国协和医科大学基础医学院药理系 北京市 100005;2.北京同仁堂股份有限公司科学研究所 北京市 100011
  • 收稿日期:2004-07-29 出版日期:2004-09-25 发布日期:2004-09-25

Effect of Jiuqiang Naoliqing on the behavior of Kunming mice

XU Hai-feng,LI Zhi-meng, YANG Nan, et al   

  1. Department of Pharmacology, School of Basic Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100005, China
  • Received:2004-07-29 Published:2004-09-25 Online:2004-09-25

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摘要： 目的评价久强脑立清(JNQ)对昆明种小鼠行为的作用。方法采用自发运动、Morris水迷宫、转杆实验、对咖啡因引起的兴奋作用、戊巴比妥钠睡眠时间、戊巴比妥钠阈下催眠剂量实验以及对戊四唑引起的惊厥作用等方法对小鼠的行为进行评价。结果和对照组相比,JNQ低剂量组可增加小鼠自发运动,中、高剂量组可以延长小鼠在转杆上的运动时间;脑立清各剂量组可以延长戊巴比妥钠睡眠时间,增加戊巴比妥钠阈下催眠剂量时的睡眠百分数,并拮抗咖啡因的兴奋作用。结论JNQ对昆明种小鼠具有镇静、安眠作用,并能增强其在运动中的平衡协调能力。

关键词: 久强脑立清, 行为, 小鼠

Abstract: ObjectiveTo observe the effect of Jiuqiang Naoliqing (JNQ) on the behavior of Kunming mice.MethodsSpontaneous movement, Morris Water Maze, Rotarod, anti caffeine test, sleeping time of pentobarbital sodium, subthreshold dose of pentobarbital sodium, and anti pentylene tetrazol test were adopted to evaluate the behavioral changes. ResultsCompared with the control group, the low dose of JNQ can increase spontaneous movement of the mice, the middle and high dose of JNQ can increase time on the rotating rods. JNQ can also increase sleeping time of pentobarbital sodium test and percent of falling asleep in subthreshold dose of pentobarbital sodium test, as well as antagonize caffeine's effect on mice. ConclusionJNQ can also do sedative and hypnotic effect on Kunming mice as well as improve their ability of balance and coordination.

Key words: Jiuqiang Naoliqing, behavior, mice