《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (09): 553-553.

• 临床研究 • 上一篇    下一篇

弓形虫感染致小儿脑性瘫痪的危险性分析

李瑞花; 冯小伟; 黄鹦   

  1. 海南省人民医院儿科脑瘫中心 海南海口市 570311
  • 收稿日期:2004-05-26 出版日期:2004-09-25 发布日期:2004-09-25

Correlation between Toxoplasma infection and occurrence of children with cerebral palsy

LI Rui-hua, FENG Xiao-wei, HUANG Ying   

  1. Center of Cerebral Palsy, Hainan People’Hospital, Haikou 570311, Hainan, China
  • Received:2004-05-26 Published:2004-09-25 Online:2004-09-25

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被引次数

10

摘要： 目的探讨先天性弓形虫感染与儿童患脑性瘫痪发生的关联性。方法 236例脑瘫患儿作为病例组,428例正常儿童作为对照组。将所有研究的病例按年龄分层为4组:～3月、～6月、～9月、～12月组,血弓形虫DNA(TOX-DNA)、弓形虫循环抗原(TOX-CAG)、血弓形虫抗体IgM(TOX-IgM)中1项或1项以上阳性,并排除其他的先天性感染疾病者确定诊断。 结果在～3月,～6月,～9月3组儿童中,其相对危险度(OR)与95%置信区间(CI)分别为:10.13、3.74—27.42,7.71、2.45—24.28,8.84、1.85—42.31,均P<0.01。在～12月组中,OR=4.30,CI:0.83—22.28,P>0.05。结论在病例组儿童中,存在弓形虫感染与脑瘫之间的关联性;检出弓形虫感染时年龄越小,发生脑瘫的危险性越大。

关键词: 弓形虫, 脑性瘫痪, 发生, 儿童

Abstract: ObjectiveTo investigate whether the Toxoplasma infection is the risk factor of occurrence of children cerebral palsy.Methods236 children with cerebral palsy and 428 normal children were included. Children were laminated to 4 groups by age:-3 months,-6 months,-9 months,-12 months. Final diagnosis was made by one or more finding following: plasma Toxoplasma DNA(TOX-DNA), plasma Toxoplasma circulating antigen(TOX-CAG), plasma Toxoplasma IgM(TOX-IgM), exclusion other congenital infected diseases.ResultsThe OR and 95%CI were 10.13,3.74-27.42 in -3 months,7.71,2.45-24.28 in -6 months,8.84,1.85-42.31 in-9 months(P<0.01 respectively), and 4.30, 0.83-22.28(P>0.05)in -12 months. ConclusionThere is correlation between the Toxoplasma infection and the children cerebral palsy; the earlier Toxoplasma infection, the greater the risk of cerebral palsy. Congenital Toxoplasma infection may be one of important factors in children cerebral palsy.

Key words: Toxoplasma, cerebral palsy, occurrence, children