《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (10): 577-579.

• 专题 •    下一篇

仿生脉冲电磁场对去卵巢骨质疏松大鼠骨生物力学性能的影响

谢肇1; 李起鸿1; 孟萍2; 谭祖键1   

  1. 1.第三军医大学西南医院骨科 重庆市 400038;2.第三军医大学西南医院老年科 重庆市 400038
  • 收稿日期:2004-03-29 出版日期:2004-10-25 发布日期:2004-10-25

Effect of bionics pulsed electromagnetic fields on the biomechanical property of ovariectomized osteoporosis rats

XIE Zhao, LI Qi-hong, MENG Ping, et al   

  1. Department of Orthopaedics, Xinan Hospital, The Third Military Medical University, Chongqing 400038, China
  • Received:2004-03-29 Published:2004-10-25 Online:2004-10-25

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摘要： 目的观察仿生脉冲电磁场(BEMF)对去卵巢大鼠腰椎和股骨生物力学性能的影响。方法 6月龄雌性未孕Wistar大鼠40只随机分为模型组(A组),假手术组(B组),BEMF治疗组(C组),雌激素治疗组(D组)。A组、C组、D组行双侧卵巢切除术,B组行假手术。术后8W,D组肌肉注射苯甲酸雌二醇,0.5mg/kg,1次/2W;C组暴露于BEMF治疗,1h/d,1次/d。A组、B组作为对照组。治疗10W后,用CHALLENGER双能X线骨密度测定仪活体测定大鼠腰椎、股骨骨密度后处死各组实验动物,取出第3腰椎、右侧股骨用INSTRON 1011生物力学测试机测定生物力学指标。结果BEMF治疗后,大鼠腰椎、股骨的结构力学(最大位移、最大载荷、最大能量吸收)和材料力学(最大应力、最大应变、弹性系数)均有改善(P<0.05)。结论BEMF可改善去卵巢大鼠腰椎和股骨的生物力学性能,增强抗骨折能力。

关键词: 仿生脉冲电磁场, 骨质疏松, 生物力学性能

Abstract: ObjectiveTo observe the effect of bionics pulsed electromagnetic fields (BEMF) on the biomechanical property of ovariectomized Wistar rats.MethodsForty 6 month old female Wistar rats were randomly divided into four different groups: ovariectomy group (group A), sham operation group (group B), BEMF+ovariectomized group (group C) and estrogen+ovariectomized group (group D). All rats were subjected to bilateral ovariectomy except group B. 8 weeks after operation, rats of group D were given estrogen 0.5 mg/kg/2 w. Rats of group C were exposed to BEMF, 1 h /d. Rats of group A and B were given nothing as control groups. All treatments was being kept for 10 weeks. After treatments finished, measuring the biomechanical property of femur and lumbar spine.ResultsThere were significant differences in the biomechanical property between group D and group A, and group C and group A (P<0.05).ConclusionBEMF can improve the biomechanical property of ovariectomized Wistar rats significantly and increase the capability of resisting fracture significantly.

Key words: bionics pulsed electromagnetic fields (BEMF), osteoporosis, biomechanical property