《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (12): 780-781.

• 临床研究 • 上一篇    下一篇

甲地孕酮对肿瘤化疗不良反应的影响

谢敏明; 刘冬生; 郑敏相; 林漳国   

  1. 东莞太平人民医院肿瘤科 广东东莞市 523900
  • 收稿日期:2004-02-26 出版日期:2004-12-25 发布日期:2004-12-25

Effect of megace on the toxicity reaction in chemotherapy of tumor

XIE Min-ming, LIU Dong-sheng, ZHENG Min-xiang, et al   

  1. Department of Oncology, The People’s Hospital of Taiping, Dong Guan 523900, Guangdong, China
  • Received:2004-02-26 Published:2004-12-25 Online:2004-12-25

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被引次数

1

摘要： 目的观察甲地孕酮(MA)在肿瘤化疗期间及化疗后对食欲、食量、体重、胃肠道反应及全身情况的影响。方法采用配对法将条件相仿的46对恶性肿瘤患者分成MA组(化疗合用MA)和对照组(单纯化疗),观察两组患者治疗期间及化疗后食欲、食量和体重的变化、胃肠道反应,以及全身情况的变化。结果治疗后,MA组患者52.2%食欲有改善,47.8%食量增加,45.7%体重增加,50%化疗期间无明显胃肠道反应,Karnofsky活动状况(KPS)积分增加>10分者占50%;对照组仅6.5%食欲有改善,4.3%食量增加,13%体重增加,28.3%无明显胃肠反应,KPS积分增加>10分者占15.2%,两组间有非常显著性差异(P<0.01)。结论MA可减轻化疗所致的恶心、呕吐反应,提高食欲,增加体重,保护骨髓,提高患者的生活质量,且未见明显副作用。

关键词: 甲地孕酮, 肿瘤, 生活质量, Karnofsky活动状况(KPS), 化疗

Abstract: ObjectiveTo observe the effect of megace (MA) on the survival condition of cancer patients in chemotherapy (CT) periods.Methods92 patients with cancer were divided into the MA group (treated with MA+CT) and control group (treated only with CT). The changing of the appetite, normal food amount, weight, gastrointestinal reaction and whole body conditions of two groups were evaluated.ResultsIn the MA group, 52.2% patients had appetite improvement, 47.8% had more food amount, 45.7% gained more weight, 50% had no obvious gastrointestinal reaction such as vomiting and nausea, and 50% had improve the survival condition according to the Karnofsky performance status (KPS) scores (increment >10). In the control group, only 6.5% had appetite improvement, 4.3% had more food amount, 13% gained more weight, 28.3% had no vomiting and nausea, and 15.2% had improved the survival condition. There was a significant difference between two groups (P<0.01).ConclusionMegace is able to reduce nausea and vomiting caused by CT, improve appetite, increase patients weight, protect bone marrow from the inhibition of CT, improve the life quality of cancer patients, and has no evident side-effects.

Key words: megace, tumor, quality of life, Karnofsky performance status (KPS), chemotherapy