《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (01): 4-6.

• 专题 • 上一篇    下一篇

骨髓间充质干细胞对股骨头坏死缺损模型修复的组织学观察

孙伟1; 李子荣1; 史振才1; 张念非1; 李艳2; 崔福斋2; 张岚1; 蔡哲1   

  1. 1.中日友好医院骨科骨坏死与关节保留重建中心 北京市 100029;2.清华大学材料科学与工程系 北京市 100084;3.中日友好临床医学研究所免疫室 北京市 100029
  • 收稿日期:2004-12-14 出版日期:2005-01-25 发布日期:2005-01-25

Histological observation on repair of bone mesenchymal stem cell in rabbit osteonecrosis of the femoral head defect model

SUN Wei,LI Zi-rong, SHI Zhen-cai, et al   

  1. Center for Osteonecrosis and Joint Preserving & Reconstruction, Department of Orthopaedic Surgery, China-Japan Friendship Hospital, Beijing100029, China
  • Received:2004-12-14 Published:2005-01-25 Online:2005-01-25

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摘要： 目的研究骨髓间充质干细胞在治疗股骨头坏死动物模型的修复作用及价值。方法建立兔双侧股骨头内骨缺损模型,并分为3组,A组为制作缺损而不填充任何材料,B组为单纯填充纳米人工骨,C组填充纳米人工骨和骨髓间充质干细胞的复合材料。对植入后 4周、8周、12周的股骨头行组织学检查。结果B组和C组在股骨头缺损修复成骨方面与A组有显著差异,C组差异性更大。结论骨髓间充质干细胞有较强的成骨作用,可促进股骨头坏死骨缺损的修复,对股骨头坏死的治疗有较大价值。

关键词: 股骨头坏死, 骨缺损, 骨髓间充质干细胞, 兔

Abstract: ObjectiveTo evaluate the effectiveness of mesenchymal stem cell (MSC) in osteonecrosis of the femoral head defect(ONFH) repair. MethodsAniaml model of ONFH defect were established with rabbits, which were divided into 3 groups,group A did not infill anything as control, nano Hydroxyapatite/collagen(nHAC) as group B,nHAC+MSC as group C.Histology change were investigated 4,8,12 weeks after operation respectively.Results groups B and C were different with group A. The difference between groups A and C was more significant. ConclusionMesenchymal stem cell has a strong activity of osteoconduction,it has a value in repairing the bone defect of ONFH and the treatment of ONFH.

Key words: osteonecrosis of the femoral head, bone defect, bone mesenchymal stem cell, rabbit