《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (01): 47-48.

• 临床研究 • 上一篇    下一篇

Alzheimer病患者吸入性肺炎的发病率及相关危险因素

高平; 秦绍森; 蔡晓杰   

  1. 卫生部北京医院神经内科 北京市 100730
  • 收稿日期:2004-09-09 出版日期:2005-01-25 发布日期:2005-01-25

Incidence and correlative risk factors of aspiration in Alzheimer's disease patients with aspiration pneumonia

GAO Ping,QIN Shao-sen, CAI Xiao-jie   

  1. Department of Neurology, Beijing Hospital, Beijing 100073, China
  • Received:2004-09-09 Published:2005-01-25 Online:2005-01-25

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摘要： 目的研究Alzheimer病(AD)患者并发吸入性肺炎的发病率及与吸入相关的危险因素。方法对 88例AD患者进行回顾性分析,调查吸入性肺炎的发病率并对可能与吸入相关的因素进行多元回归分析。结果平均观察期(3.51±0.25)年,AD患者并发吸入性肺炎的总发病率平均每年12.3%,其中轻度AD 11.1%,中度AD 12.3%,重度AD 17.6%。通过Logistic多元回归分析,与吸入相关的危险因素为:痴呆严重度、使用镇静及抗精神病药物、无症状性双侧基底节腔隙性脑梗死、日常生活能力、脑白质疏松。结论吸入性肺炎是AD常见的并发症,即使在轻度痴呆和中度痴呆患者中也并非少见。

关键词: Alzheimer病, 吸入性肺炎, 发病率, 危险因素

Abstract: ObjectiveTo investigate the incidence and correlative risk factors of aspiration in Alzheimer disease (AD) patients with aspiration pneumonia. MethodsData of 88 cases with AD were retrospectively investigated. Several possible correlative risk factors were analyzed with multiple Logistic regression. Results38 cases with AD complicated aspiration pneumonia during the observation period [average (3.51±0.25) years].The total average annual incidence of aspiration pneumonia in AD was 12.3%. The annual incidence of aspiration pneumonia in mild AD, moderate AD and severe AD were 11.1%,12.3%,17.6% respectively.The correlative risk factors of aspiration in AD patients with aspiration pneumonia were severity of AD,application of neurosedatives, silent bilateral basal ganglia lacunar infarction (SBI), decrease of activity of daily living (ADL) and leukoaraiosis (LA). ConclusionAspiration pneumonia is a common complication occurring not only in severe AD but also in mild and moderate AD.

Key words: aspiration pneumonia, incidence, Alzheimer's disease, risk factors