《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (01): 49-50.

• 临床研究 • 上一篇    下一篇

复方七叶皂苷凝胶治疗膝关节骨性关节炎的临床研究

丁明晖; 黄东锋   

  1. 中山大学第一附属医院康复科 广东广州市 510890
  • 出版日期:2005-01-25 发布日期:2005-01-25

Clinical research on Reparil-Gel for osteoarthritis of the knee

DING Ming-hui,HUANG Dong-feng   

  1. Department of Rehabilitation,the First Hospital of Zhongshan University, Guangzhou 510890, Guangdong, China
  • Published:2005-01-25 Online:2005-01-25

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被引次数

18

摘要： 目的观察复方七叶皂苷凝胶(商品名为利百素)治疗膝关节骨性关节炎的疗效与安全性。方法 60例膝关节骨性关节炎患者,随机分为2组。治疗组予复方七叶皂苷凝胶4g均匀外涂于膝关节处皮肤,每天4次;对照组予芬必得胶囊600mg,每天2次口服。共治疗6周。分别运用“Western Ontario and McMaster University 骨性关节炎指数”(WOMAC)在用药0周、2周、6周时进行评估,观察不良反应发生率。结果用药 2周后 ,治疗组、对照组治疗前后在三个子量表中所获分值有显著性差异(P<0.05),两组间治疗效果比较有显著性差异(P<0.05);用药6周后,两组治疗前后有非常显著性差异(P<0.001),两组间治疗效果比较无显著性差异(P>0.05)。治疗组未出现不良反应,对照组治疗2周后4例出现胃痛、恶心、食欲减退的表现;治疗6周后对照组8例出现胃痛、恶心、食欲减退的表现。结论复方七叶皂苷凝胶与芬必得均有较好的治疗效果,但复方七叶皂苷凝胶起效较快,副作用发生率较芬必得低。

关键词: 膝关节, 骨性关节炎, 治疗, 复方七叶皂苷凝胶, 芬必得

Abstract: ObjectiveTo compare the clinical effect and security of Reparil Gel on osteoarthritis of the knee.Methods60 patients were randomly divided into Reparil Gel group and Fenbid group, who applied Reparil Gel or take Fenbid orally respectively. Western Ontario and McMaster University Osteoarthritis Index (WOMAC) was used to assess patients' pain, joint stiffness and disability of knee on 0 week, 2 week, 6 week after treatment. The side effect was observed.ResultsBoth group showed good clinic effect on 2 weeks (P<0.05)and 6 weeks (P<0.001)after treatment. Significant difference between two group was found 2 weeks after treatment, but there was no difference 6 weeks after. There was no side effect had been observed in Reparil Gel group, while stomachache, nausea or anorexia had been found in 4 case of Fenbid group 2 weeks after, and 8 case of Fenbid group 6 weeks after.ConclusionReparil Gel are same effective as Fenbid, but less side effect happened.

Key words: knee, osteoarthritis, treatment, Reparil-Gel, Fenbid