《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (02): 99-102.

• 专题 • 上一篇    下一篇

斜床站立对兔脊髓损伤后体位性低血压的影响

潘钰; 关骅   

  1. 首都医科大学康复医学院 北京市 100068
  • 收稿日期:2004-09-14 出版日期:2005-02-25 发布日期:2005-02-25

Effect of tilting table exercise on orthostatic hypotension after spinal cord injury in rabbits

PAN Yu, GUAN Hua   

  1. Faculty of Rehabilitaion of Capital University of Medical Sciences, Beijing 100068, China
  • Received:2004-09-14 Published:2005-02-25 Online:2005-02-25

PDF (PC)

被引次数

17

摘要： 目的 建立兔脊髓损伤(SCI)后体位性低血压(OH)动物模型,探讨斜床站立训练对 OH的影响及可能的作用机制。方法 应用T5脊髓完全横断和斜床抬高 60°的方法建立兔SCI后 OH模型。训练组动物术后第4d开始斜床站立训练,共训练28d。用无创兔耳血压仪检测各组动物术后3d、10d、17d、24d和31d平卧位与60°体位动脉收缩压(SBP)和脉搏(PR)变化;用放射免疫分析法检测术后31d平卧位与60°体位血浆肾素活性(PRA)和血管紧张素Ⅱ(AngⅡ)浓度变化。结果 训练组动物术后31 d 60°体位SBP高于损伤组,60°体位SBP较平卧位平均下降值显著低于损伤组;损伤组、训练组动物平卧位和60°体位PRA、AngⅡ浓度均高于假手术组,训练组平卧位和 60°体位 PRA、AngⅡ浓度与损伤组无显著性差异。结论 兔T5脊髓完全横断可导致OH,斜床站立训练有一定治疗作用,但可能不是通过激活循环肾素-血管紧张素系统实现的。

关键词: 斜床站立训练, 体位性低血压, 脊髓损伤, 肾素血管紧张素系统

Abstract: ObjectiveTo establish an experimental model of orthostatic hypotension (OH) after spinal cord injury (SCI) in rabbits and investigate the effect and relevant mechanism of tilting table exercise on OH.MethodsRabbit model of OH was established by completely transecting animal's spinal cord at the T5 segment and putting animal on a 60° tilting table. Tilting table exercise was applied to training group for 28 days starting from 4th day after operation. Systolic blood pressure (SBP) and pulse rate (PR) were observed by non invasive sphygmobolometer of rabbit at 3rd, 10th, 17th, 24th and 31st day after the operation. The concentrations of plasma renin activity (PRA) and angiotensinⅡ (AngⅡ) of different position were detected with radio immunoassay at 31st day after operation.ResultsSBP at 60° head up tilt increased and difference of SBP between two positions decreased significantly in training group at 31st day. The concentrations of PRA and AngⅡ of SCI group and training group were higher than that of sham group. There were no significant differences in the concentrations of PRA and AngⅡ between training group and SCI group.Conclusion T5 complete SCI can induce OH in rabbits. Tilting table exercise can partially improve OH after SCI in rabbit, which may be not related to activation of the circulating renin angiotensin system.

Key words: tilting table exercise, orthostatic hypotension (OH), spinal cord injury (SCI), renin angiotensin system