《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (03): 202-205.

• 临床研究 • 上一篇    下一篇

轻度认知功能障碍的神经心理学研究和ApoE基因多态性分析

王荫华1; 陈晓红1; 汤哲2; 孟琛2   

  1. 1.北京大学第一医院神经内科神经心理室 北京市 100034;2.北京老年病医疗研究中心社会医学部 北京市 100053
  • 收稿日期:2004-05-17 出版日期:2005-03-25 发布日期:2005-03-25

Neuropsychological research and ApoE genotype polymorphism analysis in mild cognitive impairment

WANG Yin-hua, CHEN Xiao-hong, TANG Zhe, et al   

  1. Department of Neurology, The First Hospital of Peking University, Beijing 100034, China
  • Received:2004-05-17 Published:2005-03-25 Online:2005-03-25

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被引次数

37

摘要： 目的探讨轻度认知功能障碍(MCI)患者神经心理学和APoE基因多态性与健康老年的差异。方法对23例MCI患者和28例健康对照进行简易精神状态检查表、日常生活行为量表、Preffer门诊患者功能缺损调查表、物体记忆测验、词语流畅性测验、数字广度、逻辑记忆、无意义图形、画钟测验、延迟记忆、临床痴呆量表、总体衰退量表、Hachinski缺血积分量表、流调用自评抑郁量表等神经心理学及APoE基因检查。结果神经心理学检查显示MCI患者的记忆、执行功能、视空间能力以及注意力、计算力与健康对照组有显著性差异(P<0.05～0.001),尤以记忆(逻辑记忆和语义记忆)最为突出,命名保留,日常生活能力正常;APoE基因多态性检查显示,MCI患者ε4携带率约为健康对照的10倍。结论MCI是AD的危险因素,应用神经心理学敏感指标结合其他生物学指标如APoE基因多态性检测可提高AD早期诊断的敏感性和特异性。

关键词: 轻度认知功能障碍, 阿尔茨海默病(AD), 神经心理学, ApoE

Abstract: ObjectiveTo explore the differences of patients with mild cognitive impairment (MCI) and normal elderly individuals in neuropsychology and ApoE genotype polymorphism.Methods23 patients with MCI and 28 normal controls were examined with the neuropsychological test and ApoE phenotypes. The neuropsychological test included mini-mental state examination (MMSE), activities of daily living scale (ADL), Preffer outpatient disability questionnair (POD), Fuld object memory evaluation (FOM), rapid verbal retrieve (RVR), digit span (DS), logical memory (LM), Geometry figures, clock drawing test (CDT), delayed recall, clinical dementia rating scale (CDR), global deterioration scale (GDS), Hachinski ischaemic scale (HIS) and center for epidemiological studies-depression scale (CES-D).ResultsMCI cases achieved significantly lower scores than healthy elderly in all cognitive function measures (P<0.05～0.001)except ADL,POD performance and naming, especially in logical memory and semantic memory, similar with the earlier period of AD. The ApoE genotype polymorphism examination showed that the rate of ApoE epsilon 4 allele carry in MCI patients was around 10 times to that in normal controls.ConclusionIndividuals with MCI appear to be at an increased risk of developing AD. Susceptible neuropsychological marker binding other biomarker, e.g. ApoE, can raise the sensibility and specificity in early diagnosis of AD.

Key words: mild cognitive impairment, Alzheimer's disease (AD), neuropsychology, ApoE