《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (04): 245-246.

• 专题 • 上一篇    下一篇

运动对去卵巢大鼠骨组织形态计量学的影响

李爽1; 刘海全2; 罗毅文2; 刘庆思2; 黄宏兴2   

  1. 1.解放军体育学院 广东广州市 510502;2.广州中医药大学 广东广州市 510224
  • 收稿日期:2004-11-23 出版日期:2005-04-25 发布日期:2005-04-25

Effects of exercise training on bone histomorphometry of ovariectomized rats

LI Shuang, LIU Hai-quan, LUO Yi-wen, et al   

  1. PLA Institute of Physical Education, Guangzhou 510502, Guangdong, China
  • Received:2004-11-23 Published:2005-04-25 Online:2005-04-25

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被引次数

26

摘要： 目的评价运动对去卵巢大鼠骨组织形态计量学的影响。方法46只SD大鼠随机分为正常对照组(A组)、去卵巢手术组(B组)、雌激素对照组(C组)、运动组(D组)。A组行假手术,其余各组行双侧卵巢切除术,术后3个月开始为期3个月的治疗。C组用尼尔雌醇治疗,D组按要求进行运动。治疗结束后对胫骨作骨组织形态计量学分析。结果D组的骨小梁面积、骨小梁面积百分数、骨小梁周长、骨小梁数目明显高于B组,且在行卵巢切除术各组中骨小梁分离度、单位骨小梁面积破骨细胞数、每毫米破骨细胞数最低,荧光周长百分数、矿化沉积率、骨形成率最大。结论运动能增加去卵巢大鼠骨的骨量,具有促进骨形成和抑制骨吸收的双重作用。

关键词: 骨质疏松, 骨组织形态计量学, 运动训练, 去卵巢大鼠

Abstract: ObjectiveTo evaluate the effects of exercise training on bone histomorphometry of ovariectomized rats.Methods46 SD rats were randomly divided into the normal control group (group A), ovariectomized group (group B) , estrogen supplement group (group C) and exercise training group (group D). The rats of group A had a sham operation, while that of other groups was ovariectomized. 3 months after operation, the rats had been treated for 3 months. The rats of group C were given estradiol, and the rats of group D were trained by exercise. The tibia sections were studied by histomorphometric analysis.ResultsThe values of the trabeclar area, trabeclar area%, trabeclar perimeter and trabeclar number of group D were significantly higher than that of group B. The values of the trabeclar separation, osteoclast number/mm2 and osteoclast number/mm of group D were the least in all groups, which had been ovariectomized. The values of the labeled perimeter % mineral apposition rate, bone formation rate of group D were superior to that of all groups.ConclusionThe exercise training can increase bone mass of ovariectomized rats, which had double effects of promoting bone formation and restraining bone absorption.

Key words: osteoporosis, bone histomorphometry, exercise training, ovariectomized rats