《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (04): 247-249.

• 专题 • 上一篇    下一篇

VDR和CTR基因多态性与河北汉族妇女骨密度关系研究

许明慧1; 刘和娣2; 佟晓旭2   

  1. 1.北京博爱医院检验科 北京市 100068;2.河北医科大生化教研室 河北石家庄市 050017
  • 收稿日期:2004-12-08 出版日期:2005-04-25 发布日期:2005-04-25

Study of the relationship between gene polymorphism of vitamin D receptor, calcitonin receptor and bone mineral density of the Han nationality woman in Hebei

XU Ming-hui, LIU He-di, TONG Xiao-xu   

  1. Department of Laboratory, The Beijing Charity Hospital, Beijing 100068, China
  • Received:2004-12-08 Published:2005-04-25 Online:2005-04-25

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被引次数

29

摘要： 目的研究维生素D受体(VDR)和降钙素受体(CTR)基因多态性与河北汉族妇女骨密度(BMD)的关系,探讨原发性骨质疏松症(OP)发病的分子机制。方法采用聚合酶链反应-限制性片段长度多态性分析(PCR RFLP)方法对60名河北汉族妇女的VDR和CTR基因进行多态性分析,比较不同基因型各部位BMD值的差异。结果VDR Bb基因型者各部位BMD值低于bb型(P<0.05);CTR CC基因型者L1～L4 BMD值有较TC基因型者降低趋势(0.05<P<0.1);复合基因型CCBb的BMD值最低。结论VDR Bb基因型与低值BMD有密切关系;复合基因型CCBb可作为预测中国汉族妇女OP的一项遗传标志。

关键词: 维生素D受体基因多态性, 降钙素受体基因多态性, 骨密度

Abstract: ObjectiveTo study the relationship between vitamin D receptor (VDR) gene polymorphism and calcitonin receptor (CTR) gene polymorphism, and bone mineral density (BMD) of the Han nationality woman in Hebei, explore the pathogenesis of osteoporosis (OP) at the gene level.MethodsPolymorphisms of VDR gene and CTR gene were analyzed by restriction fragment length polymorphisms (RFLPs) in 60 Han nationality women in Hebei.ResultsBb genetype of VDR had lower BMD values at all sites which were measured compared with bb genetype (P<0.05); CC genetype of CTR had tendency for lower BMD values at the L1～L4 compared with CT genetype (0.05<P<0.1); BMD value of CCBb genetype was the lowest.ConclusionBb genetype of VDR has a relationship with lower BMD. CCBb genetype can act as a heredity mark of OP in Chinese Han nationality woman.

Key words: vitamin D receptor gene polymorphism, calcitonin receptor gene polymorphism, bone mineral density (BMD)