《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (04): 271-272.

• 基础研究 • 上一篇    下一篇

血清髓鞘碱性蛋白含量对脊髓损伤程度早期诊断的价值

詹瑞森1; 张朝跃1; 黄建军2   

  1. 1.中南大学湘雅三医院骨科 湖南长沙市 410013;2.吉首大学医学院 湖南吉首市 410000
  • 收稿日期:2005-01-12 出版日期:2005-04-25 发布日期:2005-04-25

The early diagnostic value of serum levels of myelin basic protein on degrees of spinal cord injury

ZHAN Rui-sen, ZHANG Zhao-yue,HUANG Jian-jun   

  1. Department of Orthopaedics, The Xiangya Third Hospital of Zhongnan University, Changsha 410013, Hu nan, China
  • Received:2005-01-12 Published:2005-04-25 Online:2005-04-25

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摘要： 目的探讨血清髓鞘碱性蛋白含量对脊髓损伤程度早期诊断的价值。方法54只家兔随机分为轻、中、重度脊髓损伤组,每组动物通过大脑皮层体感诱发电位、损伤脊髓病理组织学和损伤后动物改良Tarlov评分评定损伤程度;应用酶联免疫吸附试验检测损伤前后血清髓鞘碱性蛋白含量。结果3组实验动物血清髓鞘碱性蛋白含量损伤后均升高,在损伤后24h、48h和72h时3组间有显著性差异(P<0.05),而第7天时已无显著性差异(P>0.05)。结论血清髓鞘碱性蛋白含量可作为脊髓损伤程度早期判断指标之一,但有一定的时限性。

关键词: 脊髓损伤程度, 髓鞘碱性蛋白, 早期诊断

Abstract: ObjectiveTo investigate the early diagnostic value of serum level of myelin basic protein (MBP) on spinal cord injury (SCI).Methods54 rabbits were divided randomly into slight, moderate and severe SCI groups, and SCI degrees of each group were judged by cortical somatosensory evoked potential, histopathologic examination and Tarlov′s score. ELISA was used to determine the serum levels of MBP before and after SCI.ResultsThe serum levels of MBP of rabbits in three groups were significantly different at 24th, 48th and 72nd hour after injured (P<0.05), but there were not differences at 7th day (P>0.05).ConclusionThe serum level of MBP can be used as a early diagnostic marker for SCI.

Key words: degree of spinal cord injury, myelin basic protein, early diagnosis