《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (05): 321-323.

• 专题 •    下一篇

轻度阿尔茨海默病及轻度认知障碍患者汉语单字启动命名反应时研究

王荫华; 杨晓娜; 周晓林   

  1. 北京大学第一医院神经内科神经心理室 北京市 100034
  • 收稿日期:2005-01-13 出版日期:2005-05-25 发布日期:2005-05-25

Study of word naming reaction time of reading Chinese in patients with mild Alzheimer disease and mild cognitive impairment

WANG Yin-hua, YANG Xiao-na, ZHOU Xiao-lin   

  1. Department of Neurology, the First Hospital, Peking University, Beijing 100034,China
  • Received:2005-01-13 Published:2005-05-25 Online:2005-05-25

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被引次数

12

摘要： 目的探索轻度阿尔茨海默病(AD)和轻度认知障碍(MCI)患者在汉语词汇认知加工过程中单个汉字语义和语音时间进程及模式的改变特点。方法运用反应时方法对轻度AD和MCI患者以及年龄、性别及文化程度相匹配的正常对照(NC)进行汉语单字启动命名任务,任务采用语义、同音、变调和无关对照4种启动类型,设立长短两种刺激呈现间隔(SOA),被试对目标字进行命名,分别记录被试的反应时和错误率,通过语义和语音启动与无关对照反应时比较,判断是否出现语义或语音启动效应。结果轻度AD和MCI患者各启动类型的反应时均较正常对照延长,正常对照组在长SOA时的反应时短于短SOA时,而轻度AD组长SOA时的反应时较短SOA时长;正常对照组出现同音启动效应,而轻度AD和MCI组出现变调抑制效应。结论轻度AD和MCI汉字整体认知加工速度减慢,语音加工过程受损。

关键词: 阿尔茨海默病(AD), 轻度认知障碍(MCI), 命名任务, 反应时, 语义启动

Abstract: ObjectiveTo explore the pattern and the time course changes of semantic and phonological processing during Chinese language cognition study in patients with mild Alzheimer's disease(AD) and mild cognitive impairment (MCI).MethodsPatients with mild AD and MCI and normal controls matched with age, gender, level of education were enrolled in the single-character words naming task, which applied short and long stimulus onset asynchrony (SOA). Semantic, homophonic, semihomophonic and unrelated primes preceded the words as well as nonwords targets. Subjects were asked to read the targets aloud. Semantic and phonological priming effects were analyzed by comparing reaction time of semantic, homophonic or semihomophonic related targets to unrelated targets. The reaction time and accuracy for each response were recorded.ResultsThe mean reaction time of mild AD and MCI patients were prolonged for all types of priming in contrast with normal controls. Responses of the normal controls were faster during the long SOA comparing to short SOA, whereas the mild AD group's reaction time was longer for long SOA than for short SOA. Normal controls exhibited homophonic priming, whereas mild AD and MCI groups exhibited tonal inhibition effects.ConclusionThe speed of Chinese language cognitive processing decreased in mild AD and MCI patients. The phonological encoding and accessing ability may be impaired in mild AD and MCI.

Key words: Alzheimer's disease (AD), mild cognitive impairment (MCI), word naming task, reaction time (RT), semantic priming