《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (07): 526-528.

• 专题 • 上一篇    下一篇

胰岛素样生长因子-1与老年缺血性脑血管病及其脂代谢的相关性研究

邓微; 王碧云; 张梅丽; 谭燕; 杨宇   

  1. 广东医学院附属医院 广东湛江市 524001
  • 收稿日期:2005-04-28 出版日期:2005-07-25 发布日期:2005-07-25

Correlation between serum insulin-like growth factor-1 and lipid metabolic disorder in aged patients with ischemic cerebrovascular diseases

DENG Wei, WANG Bi-yun, ZHANG Mei-li, et al   

  1. Department of Geriatrics, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China
  • Received:2005-04-28 Published:2005-07-25 Online:2005-07-25

PDF (PC)

被引次数

9

摘要： 目的探讨老年缺血性脑血管病(ICVD)患者血清胰岛素样生长因子1(IGF1)和血清脂类水平的临床意义及相互关系。方法检测130例ICVD患者血清IGF1和总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDLC)和脂蛋白(a)[LP(a)]的水平,并与43名健康老年人比较。结果脑动脉硬化、短暂性脑缺血发作(TIA)和脑梗死(CI)急性期患者血清IGF1的含量均明显低于健康对照组(P<0.05)。TIA伴有梗死灶者血清IGF1的含量较无梗死灶者更低(P<0.05)。脑血管病组总TC、TG、LDLC和LP(a)水平均较健康老年组升高(P<0.05)。老年缺血性脑血管病组IGF1水平与TC、TG、LDL、LP(a)水平呈负相关(P<0.01)。结论血清IGF1与老年ICVD的发生发展及其脂代谢紊乱密切相关,并在脑梗死的缺血再灌注过程中发挥作用。

关键词: 老年, 缺血性脑血管病, 胰岛素样生长因子-1, 脂代谢

Abstract: ObjectiveTo investigate the changes of the serum level of insulin-like growth factor-1 (IGF-1) and lipid as well as their correlation in aged patients with ischemic cerebrovascular diseases(ICVD).MethodsSerum level of IGF-1, Lipoprotein(a) [LP(a)], total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) were detected in 130 cases of aged ICVD, as well as in 43 cases of healthy aged control.ResultsIGF-1 level in aged ICVD group was remarkably lower than that in control(P<0.05), and the levels of LP(a),TC, TG and LDL-C in aged ICVD group were significantly higher than that in control (P<0.05). The serum IGF-1 level in TIA patients with infarction was mower than those without infarction (P<0.05). In aged ICVD group, the serum IGF-1 level was negatively correlated with LP(a),TC, TG and LDL-C level (P<0.01). ConclusionIGF-1 decreased in the patients of aged ICVD, which shows a close relationship about the disorder of lipid metabolism, and may play a certain role in the course of occurrence and development of aged ICVD.

Key words: elderly, ischemic cerebrovascular diseases, insulin-like growth factor-1, lipid metabolism