《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (08): 621-622.

• 基础研究 • 上一篇    下一篇

利用胶原导管和聚四氟乙烯平板修复兔面神经损伤的实验研究

张伟; 刘威; 赵建华   

  1. 1.首都医科大学附属北京天坛医院神经外科 北京市 100050;2.山西博爱医院神经外科 山西太原市 030001;3.云南省第一人民医院神经外科 云南昆明市 650000
  • 收稿日期:2005-05-11 出版日期:2005-08-25 发布日期:2005-08-25

Repair of rabbit facial nerve with collagen conduits and expanded polytetrafluoroethylene

ZHANG Wei, LIU Wei, ZHAO Jian-hua   

  1. The Department of Neurosurgery, Beijing Tiantan Hospital,Capital University of Medical Science, Beijing 100050,China
  • Received:2005-05-11 Published:2005-08-25 Online:2005-08-25

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被引次数

18

摘要： 目的评价自体神经移植物、聚四氟乙烯平板(e-PTFE)和胶原导管在修复兔面神经损伤中的作用。方法将兔面神经主干分离、切断并隔离5mm,神经断端分别用自体神经、e-PTFE或胶原导管连接。术后第7天和1个月、3个月测定实验动物的神经传导速度。处死动物,取出移植物,计数标本断面有髓神经纤维数量。结果术后第7天,各组动物的标本中几乎均未观察到神经生长,在此后的3个月中,观察到自体神经和移植物中有轴突生长,且不同时间点之间有显著性差异,不同时间点的神经传导速度也有显著性差异。结论e-PTFE和胶原导管可以作为修复周围神经系统损伤的生物相容性材料。

关键词: 面神经, 神经再生, 组织工程, 兔

Abstract: ObjectiveTo evaluate the effects of expanded polytetrafluoroethylene (e-PTFE) and collagen tubes in the repair of facial nerve in rabbits.MethodsThe facial nerves of rabbits were transected and removed for 5 mm. The nerve ends were then repaired with an e-PTFE or collagen tube, and with an autologous nerve graft as control. After 7 days, 1 month and 3 months, the animals' neural conductive velocity were determined. And then, the nerve specimens were taken out, and the myelinated fibers across the specimen were counted with histological examination.ResultsOn the 7th day, no neural regeneration was observed. But new forming neural fibers across the biocompatible materials and autologous nerve grafts were seen in the following 3 months, while the number and conductive velocity of myelinated fibers varied significantly at the different time points.Conclusione-PTFE and collagen conduits are effective in the repair of peripheral nerves.

Key words: facial nerve, neural regeneration, tissue engineering, rabbit