《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (08): 626-627.

• 基础研究 • 上一篇    下一篇

三氧化二砷对人胃癌细胞株nm23、P53基因表达的影响

戴亚红; 刘淑梅; 孟昕; 梁桃   

  1. 哈尔滨医科大学第一临床医学消化内科 黑龙江哈尔滨市 150001
  • 收稿日期:2004-10-18 出版日期:2005-08-25 发布日期:2005-08-25

Effect of arsenic trioxide on the expressions of human gastric cancer genes nm23 and P53

DAI Ya-hong, LIUShu-mei, MENGXin,et al   

  1. The Department of Digestion, The Frist Affiliated Clinical Hospital of Harbin Medical University, Harbin 150001,Heilongjiang, China
  • Received:2004-10-18 Published:2005-08-25 Online:2005-08-25

摘要: 目的观察三氧化二砷(As2O3)对人胃癌细胞株nm23、P53基因表达的影响。方法以As2O3作用于体外培养的人胃癌细胞株,通过免疫组化技术对nm23和P53基因编码蛋白的表达进行检测。结果经As2O3作用的人胃癌细胞株nm23、P53基因编码蛋白表达减少(P<0.05)。结论As2O3具有下调nm23、P53基因编码蛋白表达作用。

关键词: 三氧化二砷(As2O3), 基因表达, 肿瘤

Abstract: ObjectiveTo detect the effect arsenic trioxide (As2O3) on the expressions of human gastric cancer genes nm23 and P53.MethodsThe expressions of proteins coded by nm23 and P53 were examined with immunohistochemistry method after treated by As2O3.ResultsThe expressions of proteins coded by nm23 and P53 decreased after treated by As2O3 (P<0.05).ConclusionAs2O3 can down-regulate the expressions of proteins coded by nm23 and P53.

Key words: arsenic trioxide (As2O3), gene expression, cancer