《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (09): 722-724.

• 基础研究 • 上一篇    下一篇

延髓头端腹外侧区在大鼠外侧下丘脑/穹窿周围区升压反应中的作用

王益光1; 刘晓霞1,2; 王玉良1; 李会全1,2; 唐可欣1   

  1. 1.潍坊医学院生理学教研室 山东潍坊市 261042;2.山东潍坊市潍坊医学院附属医院内科 山东潍坊市 261021;3.潍坊市立医院骨科 山东潍坊市 261021
  • 收稿日期:2005-08-15 出版日期:2005-09-25 发布日期:2005-09-25

Role of the rostral ventrolateral medulla in pressor response of lateral hypothalamus-perifornical region to glutamate in rats

WANG Yi-guang, LIUXiao-xia, WANG Yu-liang, et al   

  1. The Department of Physiology, Weifang Medical College, Weifang 261042,Shandong, China
  • Received:2005-08-15 Published:2005-09-25 Online:2005-09-25

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被引次数

3

摘要： 目的探讨延髓头端腹外侧区(RVL)对大鼠外侧下丘脑/穹窿周围区(LH/PF)升压反应的影响和作用机制。方法30只健康Wistar大鼠随机分成4组:酚妥拉明组;心得安组;阿托品组和谷氨酸二乙酯组,每组均用生理盐水作对照。谷氨酸钠微量注入大鼠LH/PF后,观察血压升高和心率加快反应;然后分别将酚妥拉明、心得安、阿托品和谷氨酸二乙酯微量注射到RVL,再观测注射谷氨酸钠后的血压和心率变化。结果谷氨酸钠微量注入LH/PF后大鼠的动脉血压明显升高,心率加快;RVL内分别微量注射酚妥拉明、心得安、甲基阿托品和谷氨酸二乙酯后再注射谷氨酸钠,各组大鼠的升压反应明显降低,与生理盐水对照组之间有非常显著性差异(P<0.01)。结论RVL内的α-、β-、M-和谷氨酸(Glu-)受体介导LH/PF的升压反应。

关键词: 延髓头端腹外侧区(RVL), 外侧下丘脑/穹窿周围区(LH/PF), 升压反应, 大鼠

Abstract: ObjectiveTo investigate the effect and mechanisms of rostral ventrolateral medulla (RVL) on the pressor response of lateral hypothalamus-perifornical region (LH/PF) in rats.Methods30 healthy Wistar rats were randomly divided into four groups: the phentolamine group; propranolol group; atropine group and glutamate diethyl ester group, saline was as the control in every group. After microinjection of Glu into LH/PF, the blood pressure and heart rate were observed. Then phentolamine, propranolol, atropine and glutamate diethyl ester were microinjected into RVL and the blood pressure and heart rate changes induced by microinjection of Glu were observed again.ResultsMicroinjection of Glu into LH/PF can cause the blood pressure elevating and heart rate accelerating. The pressor response of Glu to excited LH/PF could be attenuated after response of phentolamine, propranolol, atropine and glutamate diethyl ester microinjected into RVL. The blood pressures of phentolamine group; propranolol group; atropine group and glutamate diethyl ester group reduced significantly different from those in the saline control group (P<0.01).ConclusionThe α-,β-,M- and Glu-receptors in the RVL induce the pressor response of LH/PF region.

Key words: rostral ventrolateral medulla (RVL), lateral hypothalamus-perifornica (LH/PF), pressor response, rats