《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (09): 742-743.

• 临床研究 • 上一篇    下一篇

参麦注射液对慢性心力衰竭患者的神经内分泌和细胞因子的影响

胡文志; 孙烈; 杨季明; 洪梅; 蒋振忠; 张博晴; 周海波   

  1. 南京医科大学第二附属医院心内科6区 江苏南京市 210011
  • 收稿日期:2005-03-29 出版日期:2005-09-25 发布日期:2005-09-25

Effect of Shenmai Injection on neuroendocrine factors and cytokines in patients with chronic heart failure

HU Wen-zhi,SUN Lie,YAN Ji-ming,et al   

  1. Department of Cardiology, Nanjing Medical University Second Hospital, Nanjing 210011, Jiangsu, China
  • Received:2005-03-29 Published:2005-09-25 Online:2005-09-25

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摘要： 目的评价参麦注射液对慢性收缩性心力衰竭患者的疗效。方法120例慢性心功能不全患者随机分为常规治疗对照组和常规治疗加参麦注射液治疗组,每组60例,观察两组血浆肾素活性、血管紧张素Ⅱ、醛固酮、内皮素、白细胞介素-6、肿瘤坏死因子-α、心钠素、脑钠素、心功能的变化。结果两组左心室射血分数、左心室舒张末期内径、左心室收缩末期内径、纽约心功能分级及神经内分泌水平治疗后比治疗前改善(均P<0.05),治疗组优于对照组(均P<0.05)。结论参麦注射液可以改善心衰患者神经内分泌及细胞因子异常和心功能异常。

关键词: 心力衰竭, 参麦注射液, 神经内分泌, 细胞因子

Abstract: ObjectiveTo investigate the effects of Shenmai Injection(SI) on chronic systolic heart failure patients.Methods120 chronic heart failure patients were randomly divided into routine treatment and the routine treatment and SI group. The changes of angiotension Ⅱ(Ang Ⅱ), aldosterone(Ald), endothelin-1 (ET-1), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), plasm rennin activity (PRA), cardionatrin(ANP), brain natriuretic peptide (BNP), cardiac function were observed.ResultsAfter treatment, LVEF,stage of NYHA increased in two groups,LVDs, LVDd and the level of Ang Ⅱ,Ald, ET-1, IL-6, TNF-α,PRA, ANP and BNP decreased in both groups(P<0.05). LVEF, stage of NYHA in the routine treatment and SI group incresed more significantly than those in routine treatment group(P<0.05). LVEDs, LVEDd and the level of Ang Ⅱ,Ald, ET-1, IL-6, TNF-α,PRA, ANP and BNP in the routine treatment and SI group were decreased more significantly than those in routine treatment group (P<0.05).ConclusionSI can improve not only the disturbed endocrine function and cytokines, but also left ventricular function.

Key words: chronic heart failure, Shenmai Injection, neurohumoral activity, cytokines