《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (10): 814-815.

• 基础研究 • 上一篇    下一篇

雷公藤多甙对IgA肾病大鼠免疫调节的实验研究

柯清林; 呼健; 李雪巧; 郝爱真; 崔媛   

  1. 1.解放军总医院中医科 北京市 100853;2.解放军304医院 北京市 100037
  • 收稿日期:2005-08-24 出版日期:2005-10-25 发布日期:2005-10-25

Experimental study of immunoloregulation induced by tripterygium glycosides on IgA nephropathy in rats

KE Qing-lin, HUJian, LI Xue-qiao, et al   

  1. The Department of Traditional Chinese Medicine, General Hospital of PLA, Beijing 100853, China
  • Received:2005-08-24 Published:2005-10-25 Online:2005-10-25

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被引次数

28

摘要： 目的观察雷公藤多甙对实验性IgA肾病大鼠的免疫调节作用。方法采用牛血清白蛋白和葡萄球菌肠毒素复合免疫法建立大鼠实验性IgA肾病模型,比较正常对照组、模型组、雷公藤多甙组大鼠的尿红细胞2、4 h尿蛋白、肾功能,以及红细胞C3b受体花环结合率和肾组织病理改变。结果雷公藤多甙组大鼠的尿红细胞、尿蛋白、血清肌酐、血尿素氮含量均低于模型组(P<0.05),红细胞C3b受体花环率高于模型组(P<0.05),肾小球系膜区IgA沉积较模型组少,肾功能改善好于模型组。结论雷公藤多甙对实验性IgA肾病大鼠有较好的治疗作用,对出现的免疫失调有调节作用。

关键词: 免疫调节, 雷公藤多甙, IgA肾病

Abstract: ObjectiveTo observe the effect of immunoloregulation induced by tripterygium glycosides on experimental IgA nephropathy in rats.MethodsRat model of IgA nephropathy was established with bovine serum albumin and staphylococcal enterotoxins compound immunization.The urine erythrocyte,urine protein in 24 h,renal function,erythrocyte C3b receptor rosette rate and kidney constitution pathology alteration among the normal control group,model group and tripterygium glycosides group were compared.ResultsCompared with the model group,urine erythrocyte,urine protein,serum Cr and BUN reduced( P<0.05),erythrocyte C3b receptor rosette rate was higher(P<0.05),IgA depositing on glomerular mesangial region was less and renal function improved in rats of the tripterygium glycosides group.ConclusionTripterygium glycosides have better therapeutic effect and adjusting action for immune disturbance.

Key words: immunoloregulation, tripterygium glycosides, IgA nephropathy